5-HT3, receptor antagonists inhibit sensory neuropeptide release from the rat spinal cord

Neuroreport ◽  
1990 ◽  
Vol 1 (2) ◽  
pp. 104-106 ◽  
Author(s):  
A. Saria ◽  
F. Javorsky ◽  
C. Humpel ◽  
R. Gamset
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Receptor Antagonists ◽  
Neuropeptide Release

Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices

Pain ◽  
1998 ◽  
Vol 78 (1) ◽  
pp. 39-48 ◽  
Author(s):  
D M. Southall ◽  
L R. Michael ◽  
R M. Vasko
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Neuropeptide Release

Differential effects of selective tachykinin NK2 receptor antagonists in rat spinal cord

1994 ◽  
Vol 251 (1) ◽  
pp. 99-102 ◽  
Author(s):  
Zsuzsanna Wiesenfeld-Hallin ◽  
Lei Luo ◽  
Xiao-Jun Xu ◽  
Carlo Alberto Maggi
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Receptor Antagonists ◽  
Differential Effects ◽  
Nk2 Receptor ◽  
Tachykinin Nk2 Receptor

NMDA Receptor-Mediated Oscillatory Activity in the Neonatal Rat Spinal Cord Is Serotonin Dependent

1998 ◽  
Vol 79 (5) ◽  
pp. 2804-2808 ◽  
Author(s):  
Jason N. Maclean ◽  
Kristine C. Cowley ◽  
Brian J. Schmidt
Keyword(s):  
Spinal Cord ◽  
Nmda Receptor ◽  
Motor Behavior ◽  
Neonatal Rat ◽  
Network Activity ◽  
Oscillatory Activity ◽  
Rat Spinal Cord ◽  
Cell Level ◽  
Receptor Antagonists

MacLean, Jason N., Kristine C. Cowley, and Brian J. Schmidt. NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent. J. Neurophysiol. 79: 2804–2808, 1998. The effect of serotonin (5-HT) receptor blockade on rhythmic network activity and on N-methyl-d-aspartate (NMDA) receptor-induced membrane voltage oscillations was examined using an in vitro neonatal rat spinal cord preparation. Pharmacologically induced rhythmic hindlimb activity, monitored via flexor and extensor electroneurograms or ventral root recordings, was abolished by 5-HT receptor antagonists. Intrinsic motoneuronal voltage oscillations, induced by NMDA in the presence of tetrodotoxin (TTX), either were abolished completely or transformed to long-lasting voltage shifts by 5-HT receptor antagonists. Conversely, 5-HT application facilitated the expression of NMDA-receptor–mediated rhythmic voltage oscillations. The results suggest that an interplay between 5-HT and NMDA receptor actions may be critical for the production of rhythmic motor behavior in the mammalian spinal cord, both at the network and single cell level.

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