Role of ET-1 in hypoxia-induced mitosis of cultured rat carotid body chemoreceptors

Neuroreport ◽  
1999 ◽  
Vol 10 (18) ◽  
pp. 3739-3744 ◽  
Author(s):  
Mark Paciga ◽  
Cathy Vollmer ◽  
Colin Nurse
Keyword(s):  
Carotid Body ◽  
Carotid Body Chemoreceptors

Role of carotid body chemoreceptors in cardiovascular adjustments induced by hypernatremia in rats

2011 ◽  
Vol 163 (1-2) ◽  
pp. 128
Author(s):  
G.R. Pedrino ◽  
M.V. Rossi ◽  
G.H.M. Schoorlemmer ◽  
O.U. Lopes ◽  
S.L.D. Cravo
Keyword(s):  
Carotid Body ◽  
Carotid Body Chemoreceptors

ROLE OF CAROTID-BODY CHEMORECEPTORS AND THEIR REFLEX INTERACTIONS IN BRADYCARDIA AND CARDIAC ARREST

The Lancet ◽  
1979 ◽  
Vol 313 (8119) ◽  
pp. 764-767 ◽  
Author(s):  
M. De Burgh Daly ◽  
JenniferE. Angell-James ◽  
R. Elsner
Keyword(s):  
Cardiac Arrest ◽  
Carotid Body ◽  
Carotid Body Chemoreceptors

scholarly journals Role of the carotid body chemoreceptors in glucose homeostasis and thermoregulation in humans

2018 ◽  
Vol 596 (15) ◽  
pp. 3079-3085 ◽  
Author(s):  
Michael J. Joyner ◽  
Jacqueline K. Limberg ◽  
Erica A. Wehrwein ◽  
Blair D. Johnson
Keyword(s):  
Glucose Homeostasis ◽  
Carotid Body ◽  
Carotid Body Chemoreceptors

Carotid chemoreceptor activity during acute and sustained hypoxia in goats

1988 ◽  
Vol 65 (4) ◽  
pp. 1796-1802 ◽  
Author(s):  
A. M. Nielsen ◽  
G. E. Bisgard ◽  
E. H. Vidruk
Keyword(s):  
Carotid Body ◽  
Discharge Frequency ◽  
Hypoxic Exposure ◽  
Arterial Pco2 ◽  
Afferent Discharge ◽  
Carotid Body Chemoreceptors ◽  
Arterial Po2 ◽  
Sustained Hypoxia ◽  
Related Increase

The role of carotid body chemoreceptors in ventilatory acclimatization to hypoxia, i.e., the progressive, time-dependent increase in ventilation during the first several hours or days of hypoxic exposure, is not well understood. The purpose of this investigation was to characterize the effects of acute and prolonged (up to 4 h) hypoxia on carotid body chemoreceptor discharge frequency in anesthetized goats. The goat was chosen for study because of its well-documented and rapid acclimatization to hypoxia. The response of the goat carotid body to acute progressive isocapnic hypoxia was similar to other species, i.e., a hyperbolic increase in discharge as arterial PO2 (PaO2) decreased. The response of 35 single chemoreceptor fibers to an isocapnic [arterial PCO2 (PaCO2) 38-40 Torr)] decrease in PaO2 of from 100 +/- 1.7 to 40.7 +/- 0.5 (SE) Torr was an increase in mean discharge frequency from 1.7 +/- 0.2 to 5.8 +/- 0.4 impulses. During sustained isocapnic steady-state hypoxia (PaO2 39.8 +/- 0.5 Torr, PaCO2, 38.4 +/- 0.4 Torr) chemoreceptor afferent discharge frequency remained constant for the first hour of hypoxic exposure. Thereafter, single-fiber chemoreceptor afferents exhibited a progressive, time-related increase in discharge (1.3 +/- 0.2 impulses.s-1.h-1, P less than 0.01) during sustained hypoxia of up to 4-h duration. These data suggest that increased carotid chemoreceptor activity contributes to ventilatory acclimatization to hypoxia.

Control of diving responses by carotid bodies and baroreceptors in ducks

1982 ◽  
Vol 242 (1) ◽  
pp. R105-R108 ◽  
Author(s):  
R. S. Lillo ◽  
D. R. Jones
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Carotid Body ◽  
Cardiovascular Responses ◽  
Pekin Ducks ◽  
Cardiac Responses ◽  
Arterial Blood ◽  
Carotid Bodies ◽  
Carotid Body Chemoreceptors

The precise role of carotid body chemoreceptors and systemic baroreceptors in cardiovascular responses during experimental diving in ducks is controversial. The diving responses of chronically baroreceptor-denervated, chemoreceptor-denervated, and combined baroreceptor- and chemoreceptor-denervated White Pekin ducks, Anas platyrhynchos, were compared with those of intact and sham-operated birds. All three types of denervation elevated predive heart rates on average by 100-150 beats/min. During submergence, the cardiac rate of the barodenervates quickly dropped and after 60 s stabilized at levels similar to those of submerged intact ducks for the remainder of a 2-min dive. However, arterial blood pressure declined drastically in the barodenervates. Ducks without functional carotid bodies showed significant bradycardia during submergence, although heart rate only fell to the predive rate of intact animals. Birds with combined baroreceptor and chemoreceptor denervation exhibited the same degree of bradycardia as chemoreceptor denervates, and arterial blood pressure rose spectacularly during a dive. It is concluded that during experimental diving in ducks 1) cardiac responses are not baroreflexive in origin, 2) the major portion of bradycardia is due to stimulation of carotid body chemoreceptors, and 3) intact system baroreceptors appear essential for maintenance of blood pressure.

scholarly journals Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans

2014 ◽  
Vol 99 (4) ◽  
pp. 640-650 ◽  
Author(s):  
Jacqueline K. Limberg ◽  
Jennifer L. Taylor ◽  
Simmi Dube ◽  
Rita Basu ◽  
Ananda Basu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Carotid Body ◽  
Baroreflex Control ◽  
Carotid Body Chemoreceptors
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