Folate-based thymidylate synthase inhibitors in cancer chemotherapy

Anti-Cancer Drugs ◽

10.1097/00001813-199701000-00001 ◽

1997 ◽

Vol 8 (1) ◽

pp. 3-16 ◽

Author(s):

Yuzuru Takemura ◽

Ann L. Jackman

Keyword(s):

Cancer Chemotherapy ◽

Thymidylate Synthase ◽

Thymidylate Synthase Inhibitors

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Thymidylate synthase inhibitors: The in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

Advances in Enzyme Regulation ◽

10.1016/0065-2571(91)90006-8 ◽

1991 ◽

Vol 31 ◽

pp. 13-27 ◽

Author(s):

A.L. Jackman ◽

P.R. Marsham ◽

R.G. Moran ◽

R. Kimbell ◽

B.M. O'Connor ◽

...

Keyword(s):

Thymidylate Synthase ◽

Vitro Activity ◽

In Vitro Activity ◽

Thymidylate Synthase Inhibitors

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Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-003-0625-9 ◽

2003 ◽

Vol 52 (0) ◽

pp. 80-89 ◽

Author(s):

Edward Chu ◽

Marc A. Callender ◽

Michael P. Farrell ◽

John C. Schmitz

Keyword(s):

Thymidylate Synthase ◽

Anticancer Agents ◽

Thymidylate Synthase Inhibitors

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Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116136 ◽

2021 ◽

pp. 116136

Author(s):

Mohammad Mahboob Alam ◽

Azizah M. Malebari ◽

Syed Nazreen ◽

Thikryat Neamatallah ◽

Abdulraheem SA Almalki ◽

...

Keyword(s):

Breast Cancer ◽

Molecular Docking ◽

Cancer Cells ◽

Thymidylate Synthase ◽

Breast Cancer Cells ◽

Docking Studies ◽

Design Synthesis ◽

Molecular Docking Studies ◽

Thymidylate Synthase Inhibitors

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Mechanisms of Acquired Resistance to Thymidylate Synthase Inhibitors: The Role of Enzyme Stability

Molecular Pharmacology ◽

10.1124/mol.56.5.1063 ◽

1999 ◽

Vol 56 (5) ◽

pp. 1063-1070 ◽

Author(s):

Maria E. Kitchens ◽

Antonia M. Forsthoefel ◽

Karen W. Barbour ◽

H. Trent Spencer ◽

Franklin G. Berger

Keyword(s):

Thymidylate Synthase ◽

Enzyme Stability ◽

Acquired Resistance ◽

Thymidylate Synthase Inhibitors

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Pharmacodynamic Measurements and Predictors of Response to Thymidylate Synthase Inhibitors

Antifolate Drugs in Cancer Therapy ◽

10.1007/978-1-59259-725-3_18 ◽

1999 ◽

pp. 383-396

Author(s):

David Farrugia ◽

Patrick G. Johnston

Keyword(s):

Thymidylate Synthase ◽

Predictors Of Response ◽

Thymidylate Synthase Inhibitors

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Role of P53 Status on Sensitivity to Thymidylate Synthase Inhibitors and Induction of Apoptosis

Chemistry and Biology of Pteridines and Folates ◽

10.1007/978-1-4615-0945-5_73 ◽

2002 ◽

pp. 433-437

Author(s):

H. H. J. Backus ◽

H. M. Pinedo ◽

D. Wouters ◽

M. C. Koudijs ◽

C. G. Ferreira ◽

...

Keyword(s):

Thymidylate Synthase ◽

Induction Of Apoptosis ◽

Thymidylate Synthase Inhibitors

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Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors

Bioinformation ◽

10.6026/97320630004357 ◽

2010 ◽

Vol 4 (8) ◽

pp. 357-365 ◽

Author(s):

V. Srivastava ◽

S.P. Gupta ◽

M. I. Siddiqi ◽

B.N. Mishra

Keyword(s):

Molecular Docking ◽

Thymidylate Synthase ◽

Docking Studies ◽

Molecular Docking Studies ◽

Thymidylate Synthase Inhibitors

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Use of Murine L5178Y Lymphoma Thymidine Kinase Mutants for in Vitro and in Vivo Antitumour Efficacy Evaluation of Novel Thymidylate Synthase Inhibitors

Advances in Experimental Medicine and Biology - Chemistry and Biology of Pteridines and Folates ◽

10.1007/978-1-4615-2960-6_120 ◽

1993 ◽

pp. 589-592 ◽

Author(s):

T. C. Stephens ◽

M. N. Smith ◽

S. E. Waterman ◽

M. L. McCloskey ◽

A. L. Jackman ◽

...

Keyword(s):

Thymidine Kinase ◽

Thymidylate Synthase ◽

Efficacy Evaluation ◽

Thymidylate Synthase Inhibitors

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Thymidylate synthase inhibitors

Cancer Chemotherapy and Biological Response Modifiers Annual ◽

10.1016/s0921-4410(03)21001-2 ◽

2003 ◽

pp. 1-28 ◽

Author(s):

Stephen P Ackland ◽

Phillip Beale ◽

Godefridus J Peters

Keyword(s):

Thymidylate Synthase ◽

Thymidylate Synthase Inhibitors

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Drugging Protein-Protein Interfaces of a Supramolecular Assembly as a Means to Overcome Resistance to Active Site Thymidylate Synthase Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2019.11.2836 ◽

2020 ◽

Vol 118 (3) ◽

pp. 515a

Author(s):

Tigran M. Abramyan ◽

Alexander Tropsha ◽

Andrew L. Lee ◽

Paul J. Sapienza

Keyword(s):

Thymidylate Synthase ◽

Active Site ◽

Supramolecular Assembly ◽

Protein Interfaces ◽

Thymidylate Synthase Inhibitors

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