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Published By Biomedical Informatics

0973-2063, 0973-8894

2022 ◽  
Vol 18 (1) ◽  
pp. 1-13
Author(s):  
Ramanathan Sowdhamini ◽  

Saffron (Crocus sativus L.) is the low yielding plant of medicinal and economic importance. Therefore, it is of interest to report the draft genome sequence of C. sativus. The draft genome of C. sativus has been assembled using Illumina sequencing and is 3.01 Gb long covering 84.24% of genome. C. sativus genome annotation identified 53,546 functional genes (including 5726 transcription factors), 862,275 repeats and 964,231 SSR markers. The genes involved in the apocarotenoids biosynthesis pathway (crocin, crocetin, picrocrocin, and safranal) were found in the draft genome analysis.


2021 ◽  
Vol 17 (5) ◽  
pp. 557-567
Author(s):  
Mallikarjun S Beelagi ◽  

Acute bronchitis is a lower respiratory tract lung infection that causes bronchial inflammation. The known protein drug targets are peptidoglycan D, Dtranspeptidase, and DNA topoisomerase 4 subunit A for bronchitis linked infections. These are the membrane associated macromolecules which takes a major role in the formation of cell wall membrane by synthesising the cross-linked peptidoglycan. Therefore, it is of interest to design molecules with improved binding features with these protein targets. Hence, we document the molecular docking analysis data of four phytocompounds from Acacia farnesiana having optimal binding features with these targets linked to bronchitis for further consideration.


2021 ◽  
Vol 17 (5) ◽  
pp. 536-540
Author(s):  
Kirishnamoorthy Meenakumari ◽  

It is of interest to document the combined effect of furanone fluconazole and amphotericin B against the biofilm formed by Cryptococcus neoformans. The MIC values of amphotericine B and Fluconazole were observed as 20μg/ml and 60μg/ml, respectively. The MIC for the Combination (Amphotericin B/ Fluconazole) was found to be at (15/20) μg/ml drug concentration. Thus, data shows the combined effect of furanone fluconazole and amphotericine B derivative against C. neoformans.


2021 ◽  
Vol 17 (5) ◽  
pp. 530-535
Author(s):  
Shanthi Kumari ◽  

Tumor necrosis factor-alpha (TNF-alpha) is known to be linked with tumor. Therefore, it is of interest to document the Molecular docking analysis of two bioactive molecules KLUF10 and KLUF13 isolated from the marine bacteria Micrococcus sp. OUS9 with TNF alpha. We report the molecular interactions of KLUF10 and KLUF13 with TNF alpha.


2021 ◽  
Vol 17 (5) ◽  
pp. 568-672
Author(s):  
S. Saleem Basha ◽  

The use of “kabasura kudineer” (liquid soup made from Indian medicinal plants) for combating COVID-19 has been common in the states of Tamilnadu and Puducherry, India during the pandemic. Therefore, it is of interest to document the molecular docking analysis of IL-6 inhibitors with potential antiviral compounds from “kabasura kudineer” extract. We show the optimal binding features of gallic acid and luteolin with the Interleukin-6 protein for further consideration.


2021 ◽  
Vol 17 (5) ◽  
pp. 550-556
Author(s):  
Yesudass Antony Prabhu ◽  

It is of interest to document the molecular docking analysis of Cyclin-dependent kinase 1 (CDK-1) inhibitors from Chrysophyllum cainito leaves towards the treatment of tumors using the known structure of PDB ID: 5HQ0. Data shows that molecules such as 8- (Dimethylamino)-7-(3-(4-ethylphenoxy)-2d, ethyl 6-oxo-5-propylheptanoate, 2,3-dihydro-3, 5-dihydroxy-6-methyl-4h-pyran-4-one, 1,2,3- benzenetriol and 1,4-benzenediol 2,5-bis (1,1-dimethylethyl) identified in methanolic extract of C. cainito have binding features with CDK1 for further consideration.


2021 ◽  
Vol 17 (5) ◽  
pp. 593-598
Author(s):  
Sarojini K Rajinikanth ◽  

It is of interest to document data on the comparative analysis of biomass and clean fuel exposure on pulmonary function during cooking among rural women. The study consisted of 100 biomass and 100 LPG fuel using women with no smoking habits and other related illness Parameters such as FVC, FEV1, FEV1/FVC, PEFR, FEF25-75%were obtained using the computerized spirometry to assess the pulmonary function in these subjects. The collected data were analyzed using the Student t-test method and Pearson correlation. The exposure index for biomass fuel users is 69.78±27.25 showing high exposure duration during cooking. The parameters for pulmonary functions significantly declined in FVC (42.34±13.6), FEV1 (45.55±15.98), PEFR (34.11±14.78) and FEF25-75% (45.56±23.00) for biomass fuel user. However, this is not true for FEV1/FVC ratio (107.56±16.9). The increase in PFT suggests the restrictive and obstructive patterns of pulmonary diseases. There was a negative correlation between increased duration of cooking and the value of FEV1/FVC (r = -0.2961), FEF25-75% (r = -0.3519) and PEFR (r = -0.2868). Thus, the deformation of pulmonary function due to extended exposure of biomass fuel for cooking women in rural Tamilnadu is shown using parameter features such as high exposure index, overcrowded area and improper ventilated houses.


2021 ◽  
Vol 17 (5) ◽  
pp. 573-582
Author(s):  
Siva Shankar Raj ◽  

The antioxidant, antimicrobial and anticancer activity of n-hexane extract of Mollugo nudicaulis Lam. is of interest. The antioxidant activity of the extract was determined by separate methods of radical scavenging assays. Antimicrobial activity was analyzed by disc diffusion method on fungi species, gram positive and negative species. The anticancer potential of plant extract was evaluated on A2780 cell lines by MTT assay. Results exposed that, the n-hexane extract of M.nudicaulis possess comparable significant antioxidant activity with IC50 values of 12.79ą0.82, 36.65ą0.03 and 19.59ą0.26 μg/mL, on DPPH, nitric oxide and hydroxyl radical scavenging assays respectively, and also possess notable reducing power of 0.84ą0.04 (Reducing power assay) and 0.75ą0.02 (FRAB assay) at the maximum concentration of 200 μg/mL of the n-hexane extract. Antimicrobial activity of extract exhibited maximum zone of inhibition ranged from 11.1 ą 0.3 to 14 .5ą 0.3 mm on tested microorganism. The anticancer activity of plant extract found to be strong cell growth inhibitory activity with minimal IC50 values of 32.46ą0.92 μg/mL on A2780 cell lines. Collectively this study can be concluded that, the n-hexane extract of M.nudicaulis might act as possible antioxidant, antimicrobial and anticancer agents.


2021 ◽  
Vol 17 (5) ◽  
pp. 541-449
Author(s):  
Mohammed Kuddus ◽  

Biocontaminants are minute particles derived from different biological materials. Indoor biocontaminants are associated with major public health problems. In Gulf countries, it is more precarious due to the harsh climatic conditions, including high ambient temperatures and relative humidity. In addition, due to COVID-19 pandemic, most of the time public is inside their home. Therefore, the aim of the study was to determine the load of biocontaminants in the indoor environment of Hail city. The results showed that most of the bacteria are gram-positive and higher in polymicrobial (87.1%) than monomicrobial (62.7%) association. There was no significant association with sample collection time and types of isolates. The most abundant microbes found in all samples were Staphylococcus aureus followed by Bacillus spp. Among Gram-negative bacterial isolates, E. coli was most common in tested indoor air samples. The study will be useful to find the biocontaminants associated with risk factors and their impact on human health in the indoor environment, especially during the COVID-19 pandemic. These results indicate the need to implement health care awareness programs in the region to improve indoor air quality.


2021 ◽  
Vol 17 (5) ◽  
pp. 599-607
Author(s):  
Siraj DAA Khan ◽  

The prevalence of self-medication (SM) has increased in health professionals due to awareness of disease and symptoms. Incorrect use of medication caused harmful effects. To assess the knowledge, attitude and practice of health professionals, this survey was conducted. A cross-sectional study was carried out among health professionals of different specialities. Knowledge, attitude and practice-based questions were asked through an electronically distributed questionnaire. Data were statistically tested using the Chi-square test with SPSS. Most of the health professionals were aware with the term of self-medication; however the knowledge about related questions was not satisfactory. Almost half of the participants practiced self-medication. The prevalence of self-medication among participants was high. They need to be trained and educate about the incorrect use of self-medication.


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