Bone Mineral Content of Femoral Bone and the Lumbar Spine Measured in Women with Fracture of the Femoral Neck by Dual Photon Absorptiometry

1983 ◽  
Vol 179 (1) ◽  
pp. 240???245 ◽  
Author(s):  
H. Bohr ◽  
O. Schaadt
1990 ◽  
Vol 78 (2) ◽  
pp. 227-233 ◽  
Author(s):  
E. V. McCloskey ◽  
S. A. Murray ◽  
C. Miller ◽  
D. Charlesworth ◽  
W. Tindale ◽  
...  

1. We have examined the relationship between broadband ultrasound attenuation in the os calcis and measurements of bone mineral in the distal forearm and lumbar spine of normal and postmenopausal osteoporotic women. 2. Values of broadband ultrasound attenuation in postmenopausal women with vertebral osteoporotic fractures were significantly lower (35%) than in normal pre-and peri-menopausal women (55.4 ± 3.8 and 79.6 ± 0.8 dB/MHz, respectively). 3. Broadband ultrasound attenuation correlated significantly with bone mineral content measured in the distal forearm by single-photon absorptiometry (r = 0.77, P < 0.0001) and with bone mineral content (r = 0.66, P < 0.0001) and bone mineral density (r = 0.72, P < 0.0001) measured in the lumbar spine by dual-photon absorptiometry. 4. Although significant, these correlations are not sufficiently close to be predictive. However, the accuracy of broadband ultrasound attenuation in discriminating between normal subjects and patients with vertebral fracture compared very favourably with direct measurements in the spine by dual-photon absorptiometry. 5. Broadband ultrasound attenuation, but not the other measurements, correlated significantly with age in the osteoporotic patients (r = 0.50, P < 0.05). 6. These findings may reflect the partial dependence of broadband ultrasound attenuation on the intrinsic trabecular architecture of cancellous bone, the disruption of which contributes to an increase in fracture risk.


2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yasumoto Matsui ◽  
Marie Takemura ◽  
Atsushi Harada ◽  
Fujiko Ando ◽  
Hiroshi Shimokata

Bone mineral density (aBMD) is equivalent to bone mineral content (BMC) divided by area. We rechecked the significance of aBMD changes in aging by examining BMC and area separately. Subjects were 1167 community-dwelling Japanese men and women, aged 40–79 years. ABMDs of femoral neck and lumbar spine were assessed by DXA twice, at 6-year intervals. The change rates of BMC and area, as well as aBMD, were calculated and described separately by the age stratum and by sex. In the femoral neck region, aBMDs were significantly decreased in all age strata by an increase in area as well as BMC loss in the same pattern in both sexes. In the lumbar spine region, aBMDs decreased until the age of 60 in women, caused by the significant BMC decrease accompanying the small area change. Very differently in men, aBMDs increased after their 50s due to BMC increase, accompanied by an area increase. Separate analyses of BMC and area change revealed that the significance of aBMD changes in aging was very divergent among sites and between sexes. This may explain in part the dissociation of aBMD change and bone strength, suggesting that we should be more cautious when interpreting the meaning of aBMD change.


1986 ◽  
Vol 7 (10) ◽  
pp. 761-770 ◽  
Author(s):  
J. Ph. PRAET ◽  
M. H. JONCKHEER ◽  
R. REYCHLER ◽  
L. A. VERBRUGGEN

1994 ◽  
Vol 07 (03) ◽  
pp. 118-123 ◽  
Author(s):  
M. M. Petersen ◽  
A. Wenck ◽  
Henriette Strøm ◽  
E. Svalastoga

SummaryThe aim of this study was to evaluate the feasibility of using measurements of bone mineral content (BMC) and bone mineral density (BMD) by dual photon absorptiometry (DPA; Gadolinium-153), as an objective measure of limb functional status in the dog. The in vitro accuracy error expressed as the standard error of the estimate (SEE) for BMC and BMD measurements was 3.2% and 1.1% respectively, and the precision in vivo for measurements of BMC and BMD in the distal diaphysis of the tibia and fibula was 2.1% and 1.9% respectively. A significant difference in bone mineral between right and left leg was not found in normal dogs, and in these dogs the average percentage intra-individual difference, between bone mineral in the legs with the highest bone density and the legs with the lowest density, was 2.2% and 3.7% for BMC and BMD respectively. However the BMC and BMD in eight clinical cases of unilateral lameness were significantly decreased in the affected legs, when compared to the healthy contralateral legs, by 20.4% (P = 0.01) and 18.3% (P = 0.01)respectively. Measurements of BMC and BMD by DP A in weight-bearing extremities in the dog showed that bone mineral is highly sensitive to decreased loading of the extremity. This method might well be used not only as an objective measure of limb activity, but also for measurement of prospective changes in bone mineral, following treatment of musculoskeletal diseases and injuries.The feasibility of using bone mineral measurements by dual photon absorptiometry, as an objective measure of limb functional status in the dog, was evaluated. Precision and accuracy were calculated from in vitro and in vivo studies. In eight cases of unilateral lameness bone mineral was significantly decreased (20%) in the affected legs when compared to the healthy contralateral legs.


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