AGE-RELATED INCREASE IN PROTEIN KINASE B (AKT) AFTER PEDIATRIC TRAUMATIC BRAIN INJURY

2002 ◽  
Vol 30 (Supplement) ◽  
pp. A7
Author(s):  
Yi-Chen Lai ◽  
P M Kochanek ◽  
P M Shore ◽  
K Janesko ◽  
H Bayir ◽  
...  
2005 ◽  
Vol 26 (7) ◽  
pp. 915-926 ◽  
Author(s):  
Xiaopeng Zhang ◽  
Yarning Chen ◽  
Milos D Ikonomovic ◽  
Paula D Nathaniel ◽  
Patrick M Kochanek ◽  
...  

1991 ◽  
Vol 75 (6) ◽  
pp. 916-921 ◽  
Author(s):  
Robert J. Hamm ◽  
Larry W. Jenkins ◽  
Bruce G. Lyeth ◽  
Daphne M. White-Gbadebo ◽  
Ronald L. Hayes

✓ Age of the patient is one of the most important predictors of outcome following human traumatic brain injury. This study employs the fluid-percussion model to investigate the effects of aging on outcome following traumatic brain injury in rats. The results revealed that there was an age-associated increase in mortality rate following both low (1.7 to 1.8 atm) and moderate (2.00 to 2.25 atm) levels of traumatic brain injury. Age-related changes in systemic physiological, neurological, and histopathological indexes of brain injury were also examined following a low level of traumatic brain injury. Traumatic brain injury produced equivalent acute hypertension and increased plasma glucose levels in both young adult and aging rats. Injury produced an acute increase in heart rate in the young adult rat group, while the heart rate decreased in the aged rats. At low levels of brain injury, no significant gross histopathological alterations were produced in either age group. Neurological outcome was assessed by measuring the duration of suppression of a number of nonpostural and postural reflexes and more complex somatomotor functions (righting, escape, head support). Except for head support, there was a significant age-related increase in the duration of the suppression of these reflexes following brain injury. These data demonstrate that aging is associated with an increased mortality rate and greater acute neurological deficits following traumatic brain injury. These data also demonstrate the usefulness of the fluid-percussion model for studying the mechanisms responsible for the age-related increase in vulnerability to brain injury.


Author(s):  
Grace B. McKee ◽  
Laiene Olabarrieta-Landa ◽  
Paula K. Pérez-Delgadillo ◽  
Ricardo Valdivia-Tangarife ◽  
Teresita Villaseñor-Cabrera ◽  
...  

Pediatric traumatic brain injury (TBI) represents a serious public health concern. Family members are often caregivers for children with TBI, which can result in a significant strain on familial relationships. Research is needed to examine aspects of family functioning in the context of recovery post-TBI, especially in Latin America, where cultural norms may reinforce caregiving by family members, but where resources for these caregivers may be scarce. This study examined caregiver-reported family satisfaction, communication, cohesion, and flexibility at three time points in the year post-injury for 46 families of a child with TBI in comparison to healthy control families. Families experiencing pediatric TBI were recruited from a large hospital in Guadalajara, Mexico, while healthy controls were recruited from a local educational center. Results from multilevel growth curve models demonstrated that caregivers of children with a TBI reported significantly worse family functioning than controls at each assessment. Families experiencing pediatric TBI were unable to attain the level of functioning of controls during the time span studied, suggesting that these families are likely to experience long-term disruptions in family functioning. The current study highlights the need for family-level intervention programs to target functioning for families affected by pediatric TBI who are at risk for difficulties within a rehabilitation context.


Peptides ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 166-171 ◽  
Author(s):  
Chao Lin ◽  
Shou-Jiang Huang ◽  
Ning Wang ◽  
Zhi-Peng Shen

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