Is There a Role for Selective Monoamine Oxidase Inhibitor Therapy in Bulimia Nervosa? A Placebo-Controlled Trial of Brofaromine

1993 ◽  
Vol 13 (6) ◽  
pp. 415???422 ◽  
Author(s):  
S. H. KENNEDY ◽  
D. S. GOLDBLOOM ◽  
E. RALEVSKI ◽  
C. DAVIS ◽  
J. D. D??SOUZA ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Bulimia Nervosa ◽  
Monoamine Oxidase Inhibitor ◽  
Controlled Trial ◽  
Oxidase Inhibitor ◽  
Inhibitor Therapy

Amitriptyline: A controlled trial in chronic depressive states

1962 ◽  
Vol 108 (457) ◽  
pp. 859-861 ◽  
Author(s):  
Andrew Skarbek ◽  
Daphne Smedberg
Keyword(s):  
Monoamine Oxidase ◽  
Chemical Structure ◽  
Monoamine Oxidase Inhibitor ◽  
Controlled Trial ◽  
Oxidase Inhibitor ◽  
Amitriptyline Hydrochloride ◽  
Depressive States

Amitriptyline hydrochloride is 5–(3 dimethylaminopropylidine)–dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Structurally it is not related to the hydrazines and is not a monoamine oxidase inhibitor. It bears some resemblance to the phenothiazines and its chemical structure is related to imipramine, in which the central seven numbered ring is azepine, nitrogen replacing the partially unsaturated carbon of the amitriptyline cycloheptadiene ring (Dorfman, 1960; Vernier, 1961).

A Controlled Trial of Mebanazine (‘Actomol’) in Depression

1965 ◽  
Vol 111 (480) ◽  
pp. 1095-1100 ◽  
Author(s):  
J. C. Barker ◽  
I. A. Jan ◽  
M. David Enoch
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Controlled Trial ◽  
Structural Formula ◽  
Oxidase Inhibitor ◽  
Hydrazine Derivative ◽  
Treatment Of Depression

Mebanazine (‘Actomol’) introduced in 1960 for the treatment of depression is a monoamine-oxidase inhibitor hydrazine derivative having the following structural formula:

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