Amitriptyline: A controlled trial in chronic depressive states

Amitriptyline hydrochloride is 5–(3 dimethylaminopropylidine)–dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Structurally it is not related to the hydrazines and is not a monoamine oxidase inhibitor. It bears some resemblance to the phenothiazines and its chemical structure is related to imipramine, in which the central seven numbered ring is azepine, nitrogen replacing the partially unsaturated carbon of the amitriptyline cycloheptadiene ring (Dorfman, 1960; Vernier, 1961).

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A Controlled Trial of Mebanazine (‘Actomol’) in Depression

The British Journal of Psychiatry ◽

10.1192/bjp.111.480.1095 ◽

1965 ◽

Vol 111 (480) ◽

pp. 1095-1100 ◽

Cited By ~ 2

Author(s):

J. C. Barker ◽

I. A. Jan ◽

M. David Enoch

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Controlled Trial ◽

Structural Formula ◽

Oxidase Inhibitor ◽

Hydrazine Derivative ◽

Treatment Of Depression

Mebanazine (‘Actomol’) introduced in 1960 for the treatment of depression is a monoamine-oxidase inhibitor hydrazine derivative having the following structural formula:

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Ethoheptazine–Monoamine Oxidase Inhibitor Interaction in Rabbits

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y72-132 ◽

1972 ◽

Vol 50 (9) ◽

pp. 923-926 ◽

Cited By ~ 6

Author(s):

John G. Sinclair

Keyword(s):

Drug Interaction ◽

Monoamine Oxidase ◽

Chemical Structure ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor ◽

The Other ◽

Temperature Recording ◽

Drug Drug Interaction ◽

Inhibitor Interaction ◽

Clinical Drug

Previous reports indicate that meperidine but not morphine produces a marked hyperpyrexia and death in monoamine oxidase inhibitor (MAOI) pretreated rabbits. Since this interaction may be predictive of a serious clinical drug–drug interaction, several other narcotic or structurally related agents were similarly tested in this study. Ethoheptazine citrate (10 mg/kg i.v.), whose chemical structure closely resembles that of meperidine, was found to produce extreme hyperpyrexia and death in rabbits pretreated with an MAOI, phenelzine sulfate (30 mg/kg i.p.), 42 and 18 h prior to temperature recording. This interaction appears to be due to an exaggerated 5-hydroxytryptamine effect. Of the other drugs tested, methadone was found to be inconsistent in its actions whereas anileridine alphaprodine, piminodine, dextropropoxyphene, levorphanol, levallorphan, codeine, and nalorphine were shown to be inactive.

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A Report on the Effects of Phenelzine (Nardil), a Monoamine Oxidase Inhibitor, in Depressed Patients

Journal of Mental Science ◽

10.1192/bjp.106.445.1533 ◽

1960 ◽

Vol 106 (445) ◽

pp. 1533-1538 ◽

Cited By ~ 5

Author(s):

R. Middlefell ◽

I. Frost ◽

G. P. Egan ◽

H. Eaton

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Structural Formula ◽

Oxidase Inhibitor ◽

The Other ◽

Chemical Mediator ◽

Normal Concentration ◽

Depressed Patients ◽

The Brain ◽

Depressive States

Phenelzine, β-phenylethylhydrazine, of structural formula, is regarded as a potent, rapidly acting, long-lasting monoamine oxidase (M.A.O.) inhibitor. The administration of such compounds protects 5-hydroxytryptamine (serotonin) which is destroyed by M.A.O. 5-hydroxytryptamine is believed to act in the brain as a chemical mediator, the function of which is to control the pulsating action of oligodendroglial cells which supply the other brain tissues with nutrient. It has been suggested that a relative 5-hydroxytryptamine deficiency is the fundamental biochemical disorder of severe depressive states and that M.A.O. inhibitors such as phenelzine tend to promote restoration to more normal concentration and activity.

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Is There a Role for Selective Monoamine Oxidase Inhibitor Therapy in Bulimia Nervosa? A Placebo-Controlled Trial of Brofaromine

Journal of Clinical Psychopharmacology ◽

10.1097/00004714-199312000-00007 ◽

1993 ◽

Vol 13 (6) ◽

pp. 415???422 ◽

Cited By ~ 31

Author(s):

S. H. KENNEDY ◽

D. S. GOLDBLOOM ◽

E. RALEVSKI ◽

C. DAVIS ◽

J. D. D??SOUZA ◽

...

Keyword(s):

Monoamine Oxidase ◽

Bulimia Nervosa ◽

Monoamine Oxidase Inhibitor ◽

Controlled Trial ◽

Oxidase Inhibitor ◽

Inhibitor Therapy

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Possible antidepressant/mania-inducing effects of methionine: a reappraisal of the effects of methionine in chronic psychosis using modern diagnostic criteria

Psychiatry and Psychobiology ◽

10.1017/s0767399x00001619 ◽

1989 ◽

Vol 4 (3) ◽

pp. 175-181

Author(s):

J.F. Lipinski ◽

R.C. Alexander

Keyword(s):

Monoamine Oxidase ◽

Diagnostic Criteria ◽

Monoamine Oxidase Inhibitor ◽

Manic Episode ◽

Oxidase Inhibitor ◽

Descriptive Data ◽

Antidepressant Effects ◽

Chronic Psychosis

SummaryThe authors have reviewed 13 published studies on methionine administration, usually in combination with a monoamine oxidase inhibitor (MAOI), to chronically psychotic patients, using modern (DSM-III) diagnostic criteria. Four of these studies contained sufficient descriptive data to allow reappraisal of the effects. The results of the review suggest that a proportion of the patients experienced the induction of a manic episode/antidepressant effects rather than the reported worsening of schizophrenia while treated with a methionine-MAOI combination. It is suggested that these observations are consistent with recent findings that S-adenosyl-L-methionine (SAMe) has antidepressant and mania-inducing effects.

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