ANAPLASTIC ASTROCYTOMA WITH GRANULAR CELL DIFFERENTIATION

1993 ◽  
Vol 52 (3) ◽  
pp. 329
Author(s):  
H. J. Melaragno ◽  
R. A. Prayson ◽  
M. L. Estos
Keyword(s):  
Cell Differentiation ◽  
Anaplastic Astrocytoma ◽  
Granular Cell

Anaplastic astrocytoma with granular cell differentiation: Case report and review of the literature

1993 ◽  
Vol 24 (7) ◽  
pp. 805-808 ◽  
Author(s):  
Mark J. Melaragno ◽  
Richard A. Prayson ◽  
Michael A. Murphy ◽  
Samuel J. Hassenbusch ◽  
Melinda L. Estes
Keyword(s):  
Case Report ◽  
Cell Differentiation ◽  
Anaplastic Astrocytoma ◽  
Granular Cell ◽  
Review Of The Literature

scholarly journals Cutaneous epithelioid hemangiosarcoma with granular cell differentiation in a dog: a case report and review of the literature

2018 ◽  
Vol 30 (6) ◽  
pp. 951-954 ◽  
Author(s):  
Pompei Bolfa ◽  
Lusan DellaGrotte ◽  
Teri Weronko ◽  
Anibal G. Armien
Keyword(s):  
Case Report ◽  
Cell Differentiation ◽  
Membrane Vesicles ◽  
Granular Cell ◽  
Accurate Diagnosis ◽  
Ultrastructural Changes ◽  
Review Of The Literature ◽  
Neoplastic Cells ◽  
Single Entity ◽  
Immunohistochemical Markers

We report a case of cutaneous epithelioid hemangiosarcoma in a dog in which the majority of the neoplastic cells displayed histologic and ultrastructural features similar to those seen in granular cell tumors (GCTs). This intersection of hemangiosarcoma and granular cell change adds to the argument that GCTs are heterogeneous in histologic origin and underlines the fact that pathologists should not consider all GCTs as a single entity. The combination of histology in typical areas of the tumor with ultrastructural changes and the correct immunohistochemical markers can facilitate the accurate diagnosis of tumors with granular cell differentiation. Besides characteristic intracytoplasmic PAS-positive granules and ultrastructural proteinaceous accumulation within single membrane vesicles (presumably lysosomes and phagolysosomes), we suggest the following combination of markers for the diagnosis of granular cell angiosarcoma and/or hemangiosarcoma: vimentin positive, NSE and/or S100 negative, CD31 positive. We propose that the histologic granular appearance represents a metabolic defect of the neoplastic cells, which supports variability in cell origin for granular cell differentiation.

Intramedullary astrocytoma with granular cell differentiation

2007 ◽  
Vol 30 (4) ◽  
pp. 339-343 ◽  
Author(s):  
R. Rodriguez y Baena ◽  
A. Di Ieva ◽  
P. Colombo ◽  
P. Collini ◽  
P. Navarria ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Granular Cell

Granular cell differentiation: A review of the published work

2017 ◽  
Vol 44 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Michael A. Cardis ◽  
Jonathan Ni ◽  
Jag Bhawan
Keyword(s):  
Cell Differentiation ◽  
Granular Cell

scholarly journals Unusual Variant of Unicystic Ameloblastoma with CEOT-Like Areas: A Rare Case Report with Review of Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Venkata Ramanand Oruganti ◽  
Shylaja Sanjeevareddygari ◽  
Manay Srinivas Munisekhar ◽  
Sharath Kumar Reddy Eppalapalli ◽  
Raghu Vamshi Vishwakarma ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Granular Cell ◽  
Review Of Literature ◽  
Unique Case ◽  
Unicystic Ameloblastoma ◽  
Rare Case Report ◽  
Unusual Variant ◽  
Clinical Variants ◽  
Cell Variant ◽  
Odontogenic Neoplasm

Ameloblastoma is an epithelial odontogenic neoplasm with clinical and histological diversity. They are locally invasive tumors with 3 clinical variants such as solid, unicystic, and peripheral ameloblastomas, and the unicystic variant constitutes only 13%. Histologically, it shows diverse microscopic patterns that may occur isolated or in combination with other patterns. The granular cell variant accounts for 3.5% of all ameloblastoma cases. The eosinophilic granules seen in the cytoplasm of the tumor are thought to be lysosomes and presumably contribute to the pathogenesis of the tumor. Although such a phenomenon is rare in unicystic ameloblastoma, granular cell differentiation in solid multicystic ameloblastoma is a well-established phenomenon. In this paper, we present a unique case of unicystic ameloblastoma with granular cell differentiation with a brief review.

Granular cell tumors: evidence for heterogeneous tumor cell differentiation

1987 ◽  
Vol 53 (1) ◽  
pp. 52-57 ◽  
Author(s):  
J. Ulrich ◽  
Ph. U. Heitz ◽  
T. Fischer ◽  
E. Obrist ◽  
F. Gullotta
Keyword(s):  
Cell Differentiation ◽  
Tumor Cell ◽  
Granular Cell ◽  
Heterogeneous Tumor ◽  
Tumor Cell Differentiation

Silver Staining of Pancreatic Islets as Revealed by Electron Microscopy

1967 ◽  
Vol 25 ◽  
pp. 44-45
Author(s):  
Kazuaki Misugi ◽  
Nobuko Misugi ◽  
Hiroshi Yamada
Keyword(s):  
Pancreatic Islet ◽  
Silver Staining ◽  
Islet Cells ◽  
Severe Hypoglycemia ◽  
Granular Cell ◽  
Electron Microscopic Level ◽  
Staining Reaction ◽  
Electron Microscopic ◽  
Pancreatic Islet Cell ◽  
D Cell

The authors had described the fine structure of a type of pancreatic islet cell, which appeared different from typical alpha and beta cells, and tentatively considered that this third type of granular cell probably represents the D cell (Figure 1).Since silver staining has been widely used to differentiate different types of pancreatic islet cells by light microscopy, an attempt to examine this staining reaction at the electron microscopic level was made.Material and Method: Surgically removed specimens from three infants who suffered from severe hypoglycemia were used. The specimens were fixed and preserved in 20% neutral formalin. Frozen sections, 30 to 40 micron thick, were prepared and they were stained by Bielschowsky's method as modified by Suzuki (2). The stained sections were examined under a microscope and islet tissues were isolated. They were fixed in 1% osmium tetroxide in phosphate buffer for one hour and embedded in Epon 812 following dehydration through a series of alcohols and propylene oxide.

Effect of verapamil on cytoplasmic distribution of granules and microfilaments in amphibian urinary bladder

1988 ◽  
Vol 46 ◽  
pp. 324-325
Author(s):  
A.J. Mia ◽  
L.X. Oakford ◽  
T. Yorio
Keyword(s):  
Urinary Bladder ◽  
Water Flow ◽  
Morphological Changes ◽  
Granular Cell ◽  
Cytosolic Calcium ◽  
Calcium Storage ◽  
Amphibian Urinary Bladder ◽  
Vesicular Membrane ◽  
High Concentrations ◽  
Cytoskeletal System

The amphibian urinary bladder has been used as a ‘model’ system for studies of the mechanism of action of antidiuretic hormone (ADH) in stimulating transepithelial water flow. The increase in water permeability is accompanied by morphological changes that include the stimulation of apical microvilli, mobilization of microtubules and microfilaments and vesicular membrane fusion events . It has been shown that alterations in the cytosolic calcium concentrations can inhibit ADH transmembrane water flow and induce alterations in the epithelial cell cytomorphology, including the cytoskeletal system . Recently, the subapical granules of the granular cell in the amphibian urinary bladder have been shown to contain high concentrations of calcium, and it was suggested that these cytoplasmic constituents may act as calcium storage sites for intracellular calcium homeostasis. The present study utilizes the calcium antagonist, verapamil, to examine the effect of calcium deprivation on the cytomorphological features of epithelial cells from amphibian urinary bladder, with particular emphasis on subapical granule and microfilament distribution.

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