Efficacy of a Glutamine-Based Oral Rehydration Solution on the Electrolyte and Water Absorption in a Rabbit Model of Secretory Diarrhea Induced by Cholera Toxin

1998 ◽  
Vol 26 (5) ◽  
pp. 513-519 ◽  
Author(s):  
Alessandra C. Silva ◽  
Messias S. Santos-Neto ◽  
Alberto M. Soares ◽  
Manassés C. Fonteles ◽  
Richard L. Guerrant ◽  
...  
Keyword(s):  
Water Absorption ◽  
Cholera Toxin ◽  
Oral Rehydration Solution ◽  
Rabbit Model ◽  
Secretory Diarrhea ◽  
Oral Rehydration ◽  
Rehydration Solution

Are oral rehydration solutions optimized for treating diarrhea?

2021 ◽  
pp. 026010602199164
Author(s):  
Samuel N Cheuvront ◽  
Robert W Kenefick ◽  
Laura Luque ◽  
Katherine M Mitchell ◽  
Sadasivan Vidyasagar
Keyword(s):  
Water Absorption ◽  
Intestinal Absorption ◽  
Turning Point ◽  
Oral Rehydration Solution ◽  
Salt Water ◽  
Food Science ◽  
Oral Rehydration ◽  
Rehydration Solutions ◽  
Rehydration Solution ◽  
Stool Volume

Background: A historical turning point occurred in the treatment of diarrhea when it was discovered that glucose could enhance intestinal sodium and water absorption. Adding glucose to salt water (oral rehydration solution, ORS) more efficiently replaced intestinal water and salt losses. Aim: Provide a novel hypothesis to explain why mainstream use of ORS has been strongly recommended, but weakly adopted. Methods: Traditional (absorptive) and novel (secretory) physiological functions of glucose in an ORS were reviewed. Results: Small amounts of glucose can stimulate both intestinal absorption and secretion. Glucose can exacerbate a net secretory state and may aggravate pathogen-induced diarrhea, particularly for pathogens that affect glucose transport. Conclusion: A hypothesis is made to explain why glucose-based ORS does not appreciably reduce diarrheal stool volume and why modern food science initiatives should focus on ORS formulations that replace water and electrolytes while also reducing stool volume and duration of diarrhea.

scholarly journals 78. TOWARD A SUPER-ORAL REHYDRATION SOLUTION (ORS): ENHANCEMENT OF INTESTINAL WATER ABSORPTION BY A POLY-NUTRIENT SOLUTION

1987 ◽  
Vol 22 (1) ◽  
pp. 109-109
Author(s):  
A Nocerlno ◽  
M Migliavacca ◽  
A Fasano ◽  
C Verqa ◽  
A Ferrara ◽  
...  
Keyword(s):  
Water Absorption ◽  
Nutrient Solution ◽  
Oral Rehydration Solution ◽  
Oral Rehydration ◽  
Rehydration Solution

Effects of an alanyl-glutamine—based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin

Nutrition ◽  
2002 ◽  
Vol 18 (6) ◽  
pp. 458-462 ◽  
Author(s):  
Aldo A.M Lima ◽  
Graç Carvalho ◽  
Aline A Figueiredo ◽  
Ângela R Gifoni ◽  
Alberto M Soares ◽  
...  
Keyword(s):  
Water Absorption ◽  
Cholera Toxin ◽  
Rat Model ◽  
Nutrition Therapy ◽  
Secretory Diarrhea ◽  
Oral Rehydration

Oral Rehydration Solution Therapy in the Management of Children with Rotavirus Diarrhea

2009 ◽  
Vol 58 (3) ◽  
pp. 80-87 ◽  
Author(s):  
Germain Nappert ◽  
Jose Miguel Barrios ◽  
Gordon A. Zello ◽  
Jonathan M. Naylor
Keyword(s):  
Oral Rehydration Solution ◽  
Oral Rehydration ◽  
Rehydration Solution ◽  
Rotavirus Diarrhea
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