Reduced Periinfarction Mortality as a Result of Long-Term Therapy with Captopril But Not Hydralazine or Propranolol in Spontaneously Hypertensive Rats

1998 ◽  
Vol 32 (6) ◽  
pp. 884-895 ◽  
Author(s):  
Tan Nguyen ◽  
Elias El Salibi ◽  
Jean L. Rouleau
1974 ◽  
Vol 48 (s2) ◽  
pp. 181s-184s ◽  
Author(s):  
M. Fernandes ◽  
I. Sanford Smith ◽  
A. Weder ◽  
K. E. Kim ◽  
Anne B. Gould ◽  
...  

1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats the decrease in pressure is associated with a decrease in heart rate. 3. In hypertensive patients prazosin decreases blood pressure by decreasing total peripheral resistance with minor effects on cardiac output. 4. Prazosin is effective in the long-term therapy of hypertensive patients, alone and in combination with a diuretic. The effect on blood pressure is the same in the supine and standing position.


2011 ◽  
Vol 18 (11) ◽  
pp. 785-791 ◽  
Author(s):  
Nobuhiro Haga ◽  
Ken Aikawa ◽  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Masanori Nomiya ◽  
...  

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mirian Almeida Silva‐Cutini ◽  
Simone Alves Almeida ◽  
Andrews Marques Nascimento ◽  
Glaucia Rodrigues Abreu ◽  
Nazaré Souza Bissoli ◽  
...  

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