Prazosin in the Treatment of Hypertension
Keyword(s):
1. Prazosin decreases blood pressure in normotensive, renal hypertensive and spontaneous hypertensive rats. The effect is greatest in the last-named. 2. In spontaneously hypertensive rats the decrease in pressure is associated with a decrease in heart rate. 3. In hypertensive patients prazosin decreases blood pressure by decreasing total peripheral resistance with minor effects on cardiac output. 4. Prazosin is effective in the long-term therapy of hypertensive patients, alone and in combination with a diuretic. The effect on blood pressure is the same in the supine and standing position.
1998 ◽
Vol 32
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pp. 884-895
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1991 ◽
Vol 57
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pp. 517-526
2016 ◽
Vol 27
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pp. 215-220
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1980 ◽
Vol 30
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pp. 819-827
1998 ◽
Vol 83
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pp. 595-603
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2007 ◽
Vol 25
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pp. 2504-2511
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Vol 15
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pp. 351-357
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1992 ◽
Vol 19
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pp. 392-395
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