Increased Expression of L-Type Calcium Channels in Vascular Smooth Muscle Cells at Spastic Site in a Porcine Model of Coronary Artery Spasm

2000 ◽  
Vol 35 (5) ◽  
pp. 822-828 ◽  
Author(s):  
Takeshi Kuga ◽  
Hiroaki Shimokawa ◽  
Yoji Hirakawa ◽  
Yoshiaki Kadokami ◽  
Yukinori Arai ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Calcium Channels ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Porcine Model ◽  
Coronary Artery Spasm ◽  
Muscle Cells

Coronary artery spasm

2021 ◽  
pp. 16-18
Author(s):  
Hiroaki Shimokawa ◽  
Jun Takahashi
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Coronary Artery Spasm ◽  
Bypass Graft ◽  
Rho Kinase ◽  
Muscle Cells ◽  
Inflammatory Changes

Coronary artery spasm is a condition in which an epicardial coronary artery or coronary bypass graft exhibits abnormal transient constriction with the possible or subsequent development of myocardial ischaemia. Porcine models have demonstrated the important role of atherosclerotic/inflammatory changes of the coronary artery and established that hypercontraction of vascular smooth muscle cells plays a central role in the genesis of spasm and is, in part, dependent on activation of Rho-kinase, a molecular switch for vascular smooth muscle cell contraction. Fasudil, which is used for the treatment of cerebral vasospasm in Japan, is metabolized to hydroxyfasudil and functions as a selective Rho-kinase inhibitor. Recent studies demonstrated that inflammatory changes in the adventitia of the coronary artery play an important role for Rho-kinase activation of vascular smooth muscle cells. Prevention and treatment of coronary spasm is important in preventing acute coronary syndromes and sudden cardiac death.

K + Currents in Human Coronary Artery Vascular Smooth Muscle Cells

1996 ◽  
Vol 78 (4) ◽  
pp. 676-688 ◽  
Author(s):  
Maik Gollasch ◽  
Christian Ried ◽  
Rostislav Bychkov ◽  
Friedrich C. Luft ◽  
Hermann Haller
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Human Coronary Artery ◽  
K Currents

scholarly journals ROLE OF KV1.3 CHANNEL IN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION IN A PORCINE MODEL OF RESTENOSIS

2015 ◽  
Vol 65 (10) ◽  
pp. A1578
Author(s):  
Mercè Roqué ◽  
Manel Garabito ◽  
Solanes Nuria ◽  
Montserrat Rigol ◽  
Pilar Cidad ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Porcine Model ◽  
Muscle Cells ◽  
Kv1.3 Channel

Mechanics of resting isolated single vascular smooth muscle cells from bovine coronary artery

1984 ◽  
Vol 246 (3) ◽  
pp. C277-C287 ◽  
Author(s):  
A. M. VanDijk ◽  
P. A. Wieringa ◽  
M. van der Meer ◽  
J. D. Laird
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Viscous Resistance ◽  
Resting Cells ◽  
Initial Length ◽  
Arterial Smooth Muscle

The viscoelastic behavior of single resting vascular smooth muscle cells from bovine coronary artery was studied. No maintained passive force could be recorded, even when the cells were stretched to two to four times their initial length; this finding suggests that the smooth muscle cells do not contribute to the parallel elastic component in arterial smooth muscle tissue. The force during stretch of resting arterial cells was proportional to the rate of stretch (which varied between 20 and 60% of the initial length per second). This linear viscous resistance was also found for toad stomach cells when similar stretches were applied. The stress-relaxation curves of the arterial cells could be fitted to the sum of two exponential components (with half-lives of 13.1 and 0.5 s, respectively). As a result of the above findings, a model consisting of two viscoelastic elements in parallel was proposed for a single resting arterial smooth muscle cell. The viscous resistance to stretch of resting cells in a Ca2+-containing solution was not significantly (P greater than 0.01) different from that in a Ca2+-free solution. The same result was obtained for bovine coronary arterial rings. It is concluded that an adequate model for resting arterial smooth muscle should include an intracellular viscous element.

scholarly journals Inhibitory Effects of Carvedilol on Calcium Channels in Vascular Smooth Muscle Cells

2003 ◽  
Vol 44 (6) ◽  
pp. 963-978 ◽  
Author(s):  
Toshiaki Nakajima ◽  
Ji Ma ◽  
Haruko Iida ◽  
Kuniaki Iwasawa ◽  
Taisuke Jo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Calcium Channels ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibitory Effects
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