The Effects of Cortisone on Liver Blood Flow in Experimental Hemorrhagic Shock

1978 ◽  
Vol 18 (6) ◽  
pp. 440-451 ◽  
Author(s):  
AYAN GÜLGÖNEN ◽  
MERAL T. ERCAN
Keyword(s):  
Blood Flow ◽  
Hemorrhagic Shock ◽  
Liver Blood Flow ◽  
Experimental Hemorrhagic Shock

Hepatic blood flow in experimental hemorrhagic shock

1962 ◽  
Vol 202 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Edward D. Frank ◽  
Howard A. Frank ◽  
Stanley W. Jacob ◽  
Jacob Fine
Keyword(s):  
Blood Flow ◽  
Arterial Pressure ◽  
Portal Vein ◽  
Hemorrhagic Shock ◽  
Hepatic Vein ◽  
Hepatic Blood Flow ◽  
Marked Reduction ◽  
Blood Replacement ◽  
Transient Improvement ◽  
Experimental Hemorrhagic Shock

In dogs in hemorrhagic shock, the blood flow and oxygenation of the liver were measured with a catheter in a hepatic vein. There is a marked reduction in hepatic blood flow and oxygenation throughout hemorrhagic shock. There is transient improvement following blood replacement and additional transfusions. Arterial shunts into the portal vein may restore hepatic oxygenation to preshock levels. Norepinephrine does not increase hepatic blood flow even though arterial pressure is restored to normal. Dibenamine pretreatment sustains the hepatic flow to some extent during hypovolemia; antibiotic pretreated animals do not differ from controls.

Tissue blood flow in brain, liver, renal cortex, and renal medulla in experimental hemorrhagic shock

1977 ◽  
Vol 5 (3) ◽  
pp. 141-145 ◽  
Author(s):  
HIROYUKI HIRASAWA ◽  
MICHIO ODAKA ◽  
YOICHIRO TABATA ◽  
HIROTADA KOBAYASHI ◽  
HIROSHI SATO
Keyword(s):  
Blood Flow ◽  
Hemorrhagic Shock ◽  
Renal Cortex ◽  
Renal Medulla ◽  
Tissue Blood Flow ◽  
Experimental Hemorrhagic Shock

scholarly journals Preservation of hepatic blood flow by direct peritoneal resuscitation improves survival and prevents hepatic inflammation following hemorrhagic shock

2012 ◽  
Vol 303 (10) ◽  
pp. G1144-G1152 ◽  
Author(s):  
Ryan T. Hurt ◽  
Paul J. Matheson ◽  
Jason W. Smith ◽  
El Rasheid Zakaria ◽  
Saad P. Shaheen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Liver Injury ◽  
Hemorrhagic Shock ◽  
Liver Perfusion ◽  
Liver Blood Flow ◽  
Dry Weight ◽  
Treated Group ◽  
Organ Injury ◽  
Edema Formation ◽  
Shed Blood

Conventional resuscitation (CR) from hemorrhagic shock (HS) results in gut and liver hypoperfusion, organ and cellular edema, and vital organ injury. Adjunct direct peritoneal resuscitation (DPR) with dialysate prevents gut vasoconstriction, hypoperfusion, and injury. We hypothesized that DPR might also improve hepatocellular edema, inflammation, and injury. Anesthetized male SD rats were assigned to groups ( n = 8/group): 1) sham (no HS); 2) HS (40% MAP/60 min) + intravenous fluid conventional resuscitation [CR; shed blood + 2 vol saline (SAL)/30 min]; 3) HS+CR+DPR (30 ml ip 2.5% glucose dialysate); or 4) HS+CR+SAL (30 ml ip saline). Histopathology showed lung and liver injury in HS+CR and HS+CR+SAL up to 24-h postresuscitation (post-RES) that was not in shams and which was prevented by adjunct DPR. Wet-to-dry weight ratios in HS+CR revealed organ edema formation that was prevented by adjunct DPR. HS+CR and HS+CR+SAL had 34% mortality by 24-h post-RES, which was absent with DPR (0%). Liver IFN-γ and IL-6 levels were elevated in CR compared with DPR or shams. TNF-α mRNA was upregulated in CR/sham and DPR/sham. IL-17 was downregulated in DPR/sham. CXCL10 mRNA was upregulated in CR/sham but downregulated in DPR/sham. Despite restored central hemodynamic performance after CR of HS, liver blood flow was compromised up to 24 h post-RES, and the addition of DPR restores and maintains liver perfusion at 24-h post-RES. DPR prevented liver injury, histological damage, and edema formation compared with CR alone. DPR provided a mitigating anti-inflammatory dampening of the systemic inflammatory response. In all, these effects likely account for improved survivorship in the DPR-treated group.

Bone marrow pressure and blood flow and resistance in experimental hemorrhagic shock

1972 ◽  
Vol 123 (4) ◽  
pp. 380-384 ◽  
Author(s):  
Rikuhei Kita ◽  
Marion M. Witoszka ◽  
Robert W. Hopkins ◽  
Fiorindo A. Simeone
Keyword(s):  
Bone Marrow ◽  
Blood Flow ◽  
Hemorrhagic Shock ◽  
Experimental Hemorrhagic Shock

Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

1992 ◽  
Vol 67 (01) ◽  
pp. 083-087 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J M Kroon ◽  
F J Kasper ◽  
H C Schoemaker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Rat Liver ◽  
Healthy Subjects ◽  
Liver Blood Flow ◽  
Major Determinant ◽  
Tissue Type ◽  
Perfused Rat Liver ◽  
Liver Model ◽  
Type Plasminogen Activator ◽  
Proportional Change

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.

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