Prediction of Posttreatment Spermatogenesis in Patients With Testicular Cancer by Flow Cytometric Sperm Chromatin Structure Assay

1998 ◽  
pp. 947-948
Author(s):  
S. D. Fossa ◽  
P. De Angelis ◽  
S. M. Kraggerud ◽  
D. Evenson ◽  
L. Theodorsen ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Chromatin Structure ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Flow Cytometric

Prediction of Posttreatment Spermatogenesis in Patients With Testicular Cancer by Flow Cytometric Sperm Chromatin Structure Assay

1998 ◽  
Vol 160 (3 Part 1) ◽  
pp. 947-948 ◽  
Author(s):  
S.D. Fossa ◽  
P. De Angelis ◽  
S.M. Kraggerud ◽  
D. Evenson ◽  
L. Theodorsen ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Chromatin Structure ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Flow Cytometric

scholarly journals Prediction of posttreatment spermatogenesis in patients with testicular cancer by flow cytometric sperm chromatin structure assay

Cytometry ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Sophie D. Foss� ◽  
Paula De Angelis ◽  
Sigrid Marie Kraggerud ◽  
Donald Evenson ◽  
Liv Theodorsen ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Chromatin Structure ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Flow Cytometric

scholarly journals The applicability of the flow cytometric sperm chromatin structure assay in epidemiological studies. Asclepios

1998 ◽  
Vol 13 (9) ◽  
pp. 2495-2505 ◽  
Author(s):  
M. Spano ◽  
A. H. Kolstad ◽  
S. B. Larsen ◽  
E. Cordelli ◽  
G. Leter ◽  
...  
Keyword(s):  
Chromatin Structure ◽  
Epidemiological Studies ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Flow Cytometric

scholarly journals DNA damage in patients with untreated testicular cancer as measured by the sperm chromatin structure assay

2003 ◽  
Vol 94 (2) ◽  
pp. 174
Author(s):  
Hiroshi Kobayashi ◽  
Hiroshi Toma ◽  
Ryuichi Ara ◽  
Donald Evenson ◽  
Rakesh Sharma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Testicular Cancer ◽  
Chromatin Structure ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay

Evaluating human sperm DNA integrity: relationship between 8-hydroxydeoxyguanosine quantification and the sperm chromatin structure assay

Zygote ◽  
2003 ◽  
Vol 11 (4) ◽  
pp. 367-371 ◽  
Author(s):  
Isabelle Oger ◽  
Christelle Da Cruz ◽  
Gilles Panteix ◽  
Yves Menezo
Keyword(s):  
Dna Fragmentation ◽  
Chromatin Structure ◽  
Inverse Relationship ◽  
Sperm Concentration ◽  
Sperm Chromatin ◽  
Sperm Chromatin Structure Assay ◽  
Fragmentation Index ◽  
Sperm Dna ◽  
Oxidative Products ◽  
Dna Fragmentation Index

In our work, we have used 8-hydroxy-deoxyguanosine (8-OH-dG), one of the major oxidative products of sperm DNA, in a population of patients consulting for infertility. We found an inverse relationship between sperm concentration and the log of the ratio of 8-OH-dG to dG (P<0.01). On the same patients' sperm samples, the sperm chromatin structure assay (SCSA) was performed. An inverse relationship was observed between the DNA fragmentation index and sperm concentration (P<0.001). There was also a positive relationship between SCSA and log 8-OH-dG/dG. This indicates that DNA fragmentation measured by the SCSA originates in part from oxidative products. In a few patients, antioxidant treatment decreased the DNA fragmentation index below the threshold of 30% that is crucial for subfertility.

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