OVEREXPRESSION OF A MOTILITY-DEFICIENT EPIDERMAL GROWTH FACTOR RECEPTOR (EGF-R) IN HUMAN TRANSITIONAL CELL CARCINOMA (TCC) INHIBITS MATRIXMETALLOPROTEASE-9 (MMP-9)-MEDIATED MOTILITY, ANGIOGENESIS, AND METASTASIS IN NUDE MICE

1999 ◽  
pp. 111
Author(s):  
Robert Radinsky ◽  
Keiji Inoue ◽  
Joel W. Slaton ◽  
Y-B Kim ◽  
C. A. Portera ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nude Mice ◽  
Transitional Cell ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Human Transitional Cell Carcinoma

scholarly journals Epidermal growth factor receptor expression in canine transitional cell carcinoma

2015 ◽  
Vol 77 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Kiwamu HANAZONO ◽  
Shinya FUKUMOTO ◽  
Yoshio KAWAMURA ◽  
Yoshifumi ENDO ◽  
Tsuyoshi KADOSAWA ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Epidermal Growth

scholarly journals Correlation of epidermal growth factor receptor score with prognostic variables in transitional cell carcinoma of urinary bladder among north-eastern Indian population

2018 ◽  
Vol 5 (9) ◽  
pp. 3083
Author(s):  
Sasanka Kumar Barua ◽  
Nabajeet Das ◽  
Saumar Jyoti Baruah ◽  
Rajeev T. P. ◽  
Puskal Kumar Bagchi ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Systemic Disease ◽  
Transitional Cell ◽  
Growth Factor Receptor ◽  
Female Ratio ◽  
Epidermal Growth

Background: Epidermal growth factor receptor (EGFR) has demonstrated over expression in bladder tumours and correlation with stage and grade of tumours. The aim of present study was to find the relation between score of the EGFR in Transitional Cell Carcinoma (TCC) of bladder and its various prognostic variables.Methods: This is a retrospective study conducted in Dept of Urology, Gauhati Medical College Hospital between Dec 2016 and July 2017. Forty cases of TCC bladder that were operated either by TURBT or radical cystectomy have been taken. However, patients with CKD, pre-existing systemic disease and UTI were excluded from the study. Presence of EGFR and its score were analysed. The rating was done as 0 (non-immunoreactive), 1+ (weak), 2+ (moderate) and 3+ (strong). The correlation between EGFR score and the various factors like age, sex, stage, size of tumour, presence of CIS, tumour grade, muscle invasion, number of tumours and type of stalk were evaluated statistically using chi square tests.Results: Average age is 59.825 years and male to female ratio is 5.6:1. EGFR score is not significantly related with age, sex, stage of disease, muscle invasiveness or number of tumours whereas size of tumour, presence of CIS changes, grade of TCC and type of tumour stalk bears statistically significant relation with EGFR score.Conclusions: Studies have shown EGFR positivity to be associated with high tumour stage, tumour progression, and poor clinical outcome. Authors have found size >3cm, CIS changes, high grade tumours and broad-based stalks to be significantly associated with higher EGFR scores among patients with TCC of bladder. 

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