Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.

1992 ◽  
Vol 54 (1) ◽  
pp. 22-29 ◽  
Author(s):  
R Glaser ◽  
J K Kiecolt-Glaser ◽  
R H Bonneau ◽  
W Malarkey ◽  
S Kennedy ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis

Immune Response of Immunocompromised Children with Malignancies to a Recombinant Hepatitis B Vaccine

1996 ◽  
Vol 13 (5) ◽  
pp. 425-431 ◽  
Author(s):  
Sophia Polychronopoulou-Androulakaki ◽  
John P. Panagiotou ◽  
Stavroula Kostaridou ◽  
Asimina Kyratzopoulou ◽  
Stavros Haidas
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis

Gluten Intake Interferes With the Humoral Immune Response to Recombinant Hepatitis B Vaccine in Patients With Celiac Disease

PEDIATRICS ◽  
2008 ◽  
Vol 121 (6) ◽  
pp. e1570-e1576 ◽  
Author(s):  
E. Nemes ◽  
E. Lefler ◽  
L. Szegedi ◽  
A. Kapitany ◽  
J. B. Kovacs ◽  
...  
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Hepatitis B ◽  
Humoral Immune Response ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis ◽  
Humoral Immune

Immune Response to a Recombinant Hepatitis B Vaccine in Hemodialysis Patients

1990 ◽  
Vol 13 (7) ◽  
pp. 451-453 ◽  
Author(s):  
D. Docci ◽  
P.A. Cipolloni ◽  
L. Baldrati ◽  
C. Capponcini ◽  
F. Turci ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Hemodialysis Patients ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis

scholarly journals Experimental and Molecular Predictions of the Adjuvanticity of Snail Mucin on Hepatitis B Vaccine in Albino Mice

2021 ◽  
Author(s):  
Parker E. Joshua ◽  
Cynthia O. Nwauzor ◽  
Damian C. Odimegwu ◽  
Uzochukwu G. Ukachukwu ◽  
Rita O. Asomadu ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Positive Control ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis ◽  
Protein Protein Interaction ◽  
Weight Analysis ◽  
Excellent Safety Profile ◽  
Antigen Antibody ◽  
Negative Controls

AbstractAlthough aluminum-containing adjuvants are widely used in human vaccination due to their excellent safety profile, they exhibit low effectiveness with many recombinant antigens. This study investigated the adjuvanticity of snail mucin with recombinant Hepatitis B Vaccine (rHBsAg). Twenty-five (25) female mice distributed unbiasedly into 5 groups were used in the study and were administered different rHBsAg/Mucin formulation at 7 days intervals. Blood samples were collected a day following the administration for analysis. The results of liver function and body weight analysis were indications that snail mucin had no adverse effect on the mice. The treatment group (administer mucin and rHBsAg) showed significantly (P<0.05) higher mean titres of anti-HBsAg antibodies when compared with the negative controls and the positive control administered with two doses of rHBsAg. Furthermore, a comparable immune response to positive control administered with three doses rHBaAG was recorded. In silico prediction, studies of the protein-protein interaction of a homology modelled snail mucus protein and HBsAg gave an indication of enhanced HBV antigen-antibody interaction. Therefore, this study has shown that snail mucin possesses some adjuvant properties and enhances immune response towards rHBsAg vaccine. However, there is a need for further molecular dynamics studies to understand its mechanism of action.

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