COMPARISON OF FOVEAL THICKNESS MEASURED WITH THE RETINAL THICKNESS ANALYZER AND OPTICAL COHERENCE TOMOGRAPHY

Purpose: To investigate the correlation between outer and inner retina optical coherence tomography (OCT) biomarkers and visual acuity in patients with idiopathic epiretinal membrane (iERM) and identify which of them may be predictive of visual function. Methods: A retrospective cross-sectional single-center study was conducted that included patients diagnosed with iERM. Spectral domain OCT images were obtained and assessed qualitatively and quantitatively. The association of OCT parameters with best corrected visual acuity was analyzed. Results: Charts of 97 eyes of 97 patients were reviewed. Central foveal thickness, maximal retinal thickness (MRT), photoreceptor outer segment length, outer foveal thickness, ganglion cell-inner plexiform layer complex thickening, inner retinal thickness and inner retinal layer irregularity index were among the major outcome measures. OCT scans were also assessed for the presence of cotton ball sign, ellipsoid zone disruption, ectopic inner foveal layer, disorganization of retinal inner layers (DRIL), intraretinal fluid, subretinal fluid (SRF) and epimacular membrane rip. Univariate analysis showed statistically significant association between all the aforementioned parameters with worse vision, except for cotton ball sign and SRF. Multivariate analysis found that MRT and severe DRIL were strongly correlated with worse vision ( p < 0.001). Conclusion: MRT and severe DRIL should be considered as negative prognostic factors for visual acuity.

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RETINAL THICKNESS MEASUREMENTS WITH OPTICAL COHERENCE TOMOGRAPHY AND THE SCANNING RETINAL THICKNESS ANALYZER

Retina ◽

10.1097/00006982-200102000-00010 ◽

2001 ◽

Vol 21 (1) ◽

pp. 57-61 ◽

Cited By ~ 54

Author(s):

SUGURU KONNO ◽

JUN AKIBA ◽

AKITOSHI YOSHIDA

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Optical Coherence ◽

Retinal Thickness Analyzer ◽

Thickness Measurements

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Optical Coherence Tomography and Retinal Thickness Analyzer Features of Spontaneous Resolution of Vitreomacular Traction Syndrome: A Case Report

European Journal of Ophthalmology ◽

10.1177/112067210401400113 ◽

2004 ◽

Vol 14 (1) ◽

pp. 67-70 ◽

Cited By ~ 8

Author(s):

P. Carpineto ◽

M. Ciancaglini ◽

A. Aharrh-gnama ◽

L. Agnifili ◽

L. Mastropasqua

Keyword(s):

Optical Coherence Tomography ◽

Case Report ◽

Retinal Thickness ◽

Spontaneous Resolution ◽

Vitreomacular Traction ◽

Optical Coherence ◽

Retinal Thickness Analyzer ◽

Vitreomacular Traction Syndrome

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Macular Thickness Assessed with Optical Coherence Tomography in Young Chinese Myopic Patients

Journal of Ophthalmology ◽

10.1155/2015/715798 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Minghui Zhao ◽

Qiang Wu ◽

Ping Hu ◽

Lili Jia

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Pressure ◽

Negative Correlation ◽

Retinal Thickness ◽

Macular Thickness ◽

Optical Coherence ◽

Foveal Thickness ◽

Positive Correlation ◽

Central Foveal Thickness ◽

The Mean

Purpose.To evaluate the variations in macular thickness in young Chinese myopic persons and the association with axial length (AL), spherical equivalence refraction (SE), age, intraocular pressure, and sex.Methods.In total, 133 young Chinese myopic subjects between 18 and 30 years of age were selected. The macular thickness was assessed using third-generation optical coherence tomography. AL, intraocular pressure, and SE were also measured.Results.The mean central foveal thickness was191.1±15.3 µm. The macula was consistently thinner in women than in men. Central foveal thickness had a significant positive correlation with AL and a negative correlation with SE. In the inner and outer regions, the macular thickness had a positive correlation with SE and negative correlation with AL.Conclusions.The retina was thinner in women than in men. Associated with myopic progression and AL extension, the central foveal thickness increased, while the retinal thickness of the inner and outer regions decreased.

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Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography

Tomography ◽

10.3390/tomography8010016 ◽

2022 ◽

Vol 8 (1) ◽

pp. 189-199

Author(s):

Klaudia Ulfik-Dembska ◽

Sławomir Teper ◽

Michał Dembski ◽

Anna Nowińska ◽

Edward Wylęgała

Keyword(s):

Optical Coherence Tomography ◽

Epiretinal Membrane ◽

Retinal Thickness ◽

Foveal Avascular Zone ◽

Optical Coherence ◽

Foveal Thickness ◽

Avascular Zone ◽

Percentage Area ◽

Retinal Structure ◽

Support Decision Making

Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group (p = 0.044). Average retinal thickness and foveal thickness were significantly higher in the ERM group (both p = 0.001). Moreover, 64 (41.5%) patients exhibited no metamorphopsia, while 46 (29.8%) and 44 (28.7%) patients exhibited moderate and extensive metamorphopsias, respectively. Meanwhile, FAZ was negatively correlated with central retinal thickness in the ERM group. The vessel area (p = 0.0017) and vessel percentage area (p = 0.044) were significantly greater in the ERM group. Conclusions: Changes observed in the superficial plexus in OCTA are related to the severity of metamorphopsia and can be further evaluated to support decision making regarding the surgical management of idiopathic ERM.

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Imaging Retinal Depression Sign in Sickle Cell Anemia Using Optical Coherence Tomography and the Retinal Thickness Analyzer

Archives of Ophthalmology ◽

10.1001/archopht.123.9.1278 ◽

2005 ◽

Vol 123 (9) ◽

pp. 1278 ◽

Cited By ~ 6

Author(s):

Akbar Shakoor

Keyword(s):

Optical Coherence Tomography ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Retinal Thickness ◽

Optical Coherence ◽

Retinal Thickness Analyzer

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Retinal Optical Coherence Tomography Metrics Are Unchanged in Verubecestat Alzheimer’s Disease Clinical Trial but Correlate with Baseline Regional Brain Atrophy

Journal of Alzheimer s Disease ◽

10.3233/jad-200735 ◽

2021 ◽

Vol 79 (1) ◽

pp. 275-287

Author(s):

Robert C. Sergott ◽

Annaswamy Raji ◽

James Kost ◽

Cyrille Sur ◽

Saheeda Jackson ◽

...

Keyword(s):

Clinical Trial ◽

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Brain Atrophy ◽

Retinal Thickness ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Retinal Nerve Fiber

Background: We performed exploratory analyses of retinal thickness data from a clinical trial of the AβPP cleaving enzyme (BACE) inhibitor verubecestat in patients with Alzheimer’s disease (AD). Objective: To evaluate: 1) possible retinal thickness changes following BACE inhibition; and 2) possible association between retinal thickness and brain atrophy. Methods: Retinal thickness was measured using spectral-domain optical coherence tomography in a 78-week randomized placebo-controlled trial of verubecestat in 1,785 patients with mild-to-moderate AD. Changes from baseline in retinal pigment epithelium, macular grid retinal nerve fiber layer, central subfield retinal thickness, and macular grid volume were evaluated for verubecestat versus placebo. Correlation analyses were performed to investigate the potential association between macular grid retinal nerve fiber layer and central subfield retinal thickness with brain volumetric magnetic resonance imaging (vMRI) data at baseline, as well as correlations for changes from baseline at Week 78 in patients receiving placebo. Results: Verubecestat did not significantly alter retinal thickness during the trial compared with placebo. At baseline, mean macular grid retinal nerve fiber layer and central subfield retinal thickness were weakly but significantly correlated (Pearson’s r values≤0.23, p-values < 0.01) with vMRI of several brain regions including whole brain, hippocampus, and thalamus. At Week 78, correlations between retinal thickness and brain vMRI changes from baseline in the placebo group were small and mostly not statistically significant. Conclusion: BACE inhibition by verubecestat was not associated with adverse effects on retinal thickness in patients with mild-to-moderate AD. Correlations between retinal thickness and brain volume were observed at baseline. Trial registration: Clinicaltrials.gov NCT01739348 (registered December 3, 2012; https://clinicaltrials.gov/ct2/show/NCT01739348).

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