Comparison of the Mini-cone Biopsy With the Punch Biopsy and Papanicolaou Smear

1974 ◽  
Vol 67 (8) ◽  
pp. 903-914
Author(s):  
ELI M. NADEL ◽  
HERBERT B. TAYLOR
Keyword(s):  
Punch Biopsy ◽  
Papanicolaou Smear ◽  
Cone Biopsy

scholarly journals Significance of punch biopsy and endocervical curretage in diagnostics of cervical intraepithelial lesions

2006 ◽  
Vol 63 (12) ◽  
pp. 995-999
Author(s):  
Milana Panjkovic ◽  
Tatjana Ivkovic-Kapicl
Keyword(s):  
Biopsy Specimen ◽  
Diagnostic Procedures ◽  
Punch Biopsy ◽  
Cervical Lesions ◽  
Diagnostic Protocol ◽  
Cervical Intraepithelial Lesions ◽  
Cone Biopsy ◽  
Intraepithelial Lesions ◽  
Exact Correlation ◽  
Cervical Conization

Background/Aim. Diagnostic procedures during the detection of cervical intraepithelial lesions (CIN) are a combination of cytology, colposcopy, punch biopsy and endocervical curretage. An optimal therapeutic approach according to the distribution, size and grade of cervical lesions is the result of this diagnostic protocol. This study was carried out to assess reliability of the punch biopsy and endocervical curretage in diagnostics of cervical intraepithelial lesions. Methods. Fifty patients undergoing cervical conization were studied retrospectively to evaluate the correlation between the grade of preoperative punch biopsy and endocervical curretage, and the grade of the dysplastic epithelial changes in the cone biopsy. CIN grade was established according to the WHO/ISGYP classification and comparation of the results was performed after that. Results. Out of the total number of patient, 89.36% of them with dysplastic epithelial changes on cone biopsy had also dysplastic changes in the preoperative punch biopsy. An exact correlation between CIN grades was identified in 56% of the cases, 20% in CIN2, and 36% in CIN3 cases. There were 24.14% patients with negative endocervical curretage, while only in one case the cone biopsy was negative, too. Among the remaining 22 patients with CIN changes in endocervical curretage specimens, only one had a negative cone biopsy. An exact correlation of CIN grade was identified in 37.93% of the cases, 13.79% of CIN2, and 24.14% of the CIN3 cases. Conclusion. There was a positive cor relation between the CIN grades in punch and cone biopsy, as well as between the grade on the endocervical curretage and cone biopsy specimen, but with the lower degree than previous.

DIAGNOSTIC COLPOSCOPIC ACCURACY BY THE GYNOCULAR AND A STATIONARY COLPOSCOPE

2015 ◽  
Vol 31 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Helena Kopp Kallner ◽  
Maria Persson ◽  
Marcus Thuresson ◽  
Daniel Altman ◽  
Isaac Shemer ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Sensitivity And Specificity ◽  
Low Cost ◽  
Kappa Statistic ◽  
Punch Biopsy ◽  
Cervical Cytology ◽  
Cervical Lesions ◽  
High Agreement ◽  
Abnormal Cervical Cytology ◽  
Cone Biopsy

Objectives: The aim of this study was to evaluate the diagnostic accuracy of sensitivity and specificity of cervical lesions by the low-cost, portable Gynocular colposcope and a stationary colposcope, in women referred for colposcopy with abnormal cervical cytology.Methods: A randomized cross-over clinical trial for evaluating the diagnostic accuracy in detecting cervical lesions by the Gynocular and a stationary colposcope. The Swede score systematic colposcopy system was used for evaluation of colposcopic abnormalities. Directed punch biopsy and excisional cone biopsy were used as the “gold-standard” by histologically confirmed high grade cervical lesions CIN2+ (CIN2, CIN3, CIN3+). In total, 123 women referred for colposcopy due to abnormal cervical cytology were recruited at the Department of Obstetrics and Gynecology, Danderyd Hospital, Stockholm, Sweden. The percentage agreement and the kappa statistic were calculated for Swede score by the Gynocular and a stationary colposcope. Swede scores were compared with the results from directed punch biopsy and excisional cone biopsy.Results: The Gynocular and the stationary colposcope had a high agreement of Swede scores with a Kappa statistic of 0.947, p < .0001. Punch biopsy diagnosed CIN2+ (CIN2, CIN3, and invasive cancer) in 44 (35.7 percent) women while cytology detected CIN2+ in 34 (27.6 percent) women. There were no significant differences of the sensitivity and specificity for different Swede scores by the Gynocular or a stationary colposcope in detecting CIN 2+.Conclusions: There were no significant differences in sensitivity or specificity in detecting cervical lesions by the Gynocular or stationary colposcope. The Gynocular is as accurate in diagnosing cervical lesions as a stationary colposcope.

An analysis of the determinants of negative cone biopsies

1991 ◽  
Vol 1 (3) ◽  
pp. 121-124
Author(s):  
R. V. Persad ◽  
M. L. Forman
Keyword(s):  
Punch Biopsy ◽  
Waiting List ◽  
Cervical Smear ◽  
Complete Excision ◽  
Cone Biopsy ◽  
First Time ◽  
Biopsy Rate

Between January and December 1989, 608 colposcopies were performed under the waiting list initiative at St Mary's Hospital in Manchester on patients seen for the first time after an abnormal cervical smear. Following colposcopy, 100 of these patients were subjected to cone biopsies for the management of cervical intra-epithelial neoplasia (CIN). The negative cone biopsy rate was 9%. The authors outline the reasons for its occurrence following a review of all the histologic and cytologic material for this group. The main reason for the negative cone biopsies in this series was the disappearance of the abnormal epithelium, presumably due to fortuitous complete excision or regression of the lesion following colposcopic punch biopsy.

The oral mucosal punch biopsy. A report of 140 cases

1992 ◽  
Vol 128 (6) ◽  
pp. 815-817 ◽  
Author(s):  
D. Eisen
Keyword(s):  
Punch Biopsy

Using Suture Removal Kit for Punch Biopsy

2001 ◽  
Vol 27 (2) ◽  
pp. 219-219
Author(s):  
Raymond T. Kuwahara ◽  
Jerri A. Alexiou
Keyword(s):  
Punch Biopsy

scholarly journals Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study

2021 ◽  
Vol 14 ◽  
pp. 175628642110043
Author(s):  
Nadine Egenolf ◽  
Caren Meyer zu Altenschildesche ◽  
Luisa Kreß ◽  
Katja Eggermann ◽  
Barbara Namer ◽  
...  
Keyword(s):  
Neurological Examination ◽  
Punch Biopsy ◽  
Small Fiber Neuropathy ◽  
Fiber Density ◽  
Axon Reflex ◽  
Small Fiber ◽  
Corneal Confocal Microscopy ◽  
Intraepidermal Nerve Fiber Density ◽  
Number Of Patients ◽  
Skin Punch Biopsy

Background and aims: Small fiber neuropathy (SFN) is increasingly suspected in patients with pain of uncertain origin, and making the diagnosis remains a challenge lacking a diagnostic gold standard. Methods: In this case–control study, we prospectively recruited 86 patients with a medical history and clinical phenotype suggestive of SFN. Patients underwent neurological examination, quantitative sensory testing (QST), and distal and proximal skin punch biopsy, and were tested for pain-associated gene loci. Fifty-five of these patients additionally underwent pain-related evoked potentials (PREP), corneal confocal microscopy (CCM), and a quantitative sudomotor axon reflex test (QSART). Results: Abnormal distal intraepidermal nerve fiber density (IENFD) (60/86, 70%) and neurological examination (53/86, 62%) most frequently reflected small fiber disease. Adding CCM and/or PREP further increased the number of patients with small fiber impairment to 47/55 (85%). Genetic testing revealed potentially pathogenic gene variants in 14/86 (16%) index patients. QST, QSART, and proximal IENFD were of lower impact. Conclusion: We propose to diagnose SFN primarily based on the results of neurological examination and distal IENFD, with more detailed phenotyping in specialized centers.

Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

2021 ◽  
pp. 106689692110029
Author(s):  
Kerschen Anja ◽  
Dano Hélène ◽  
Van Eeckhout Pascal ◽  
Marot Liliane ◽  
Van Bockstal Mieke
Keyword(s):  
Present Report ◽  
Paget’S Disease ◽  
Growth Factor Receptor ◽  
Punch Biopsy ◽  
Paget's Disease ◽  
Cytokeratin 7 ◽  
In Situ Carcinoma ◽  
Epidermal Growth ◽  
Mammary Paget’S Disease

Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast.

Sign in / Sign up

Export Citation Format

Share Document