Isothermal Gas Chromatographic Method for the Rapid Determination of Felbamate Concentration in Human Serum

1995 ◽  
Vol 17 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Michael A. Poquette
Keyword(s):  
Human Serum ◽  
Chromatographic Method ◽  
Rapid Determination ◽  
Gas Chromatographic Method ◽  
Isothermal Gas

A new gas chromatographic method for determination of amino acid levels in human serum

1980 ◽  
Vol 105 (2) ◽  
pp. 201-211 ◽  
Author(s):  
Hartmut Frank ◽  
Albert Rettenmeier ◽  
Helmut Weicker ◽  
Graeme J. Nicholson ◽  
Ernst Bayer
Keyword(s):  
Amino Acid ◽  
Human Serum ◽  
Chromatographic Method ◽  
Amino Acid Levels ◽  
Gas Chromatographic Method

Qualitative and Quantitative Determination of Methaqualone in Serum by Gas Chromatography

1974 ◽  
Vol 20 (2) ◽  
pp. 249-254 ◽  
Author(s):  
M A Evenson ◽  
G L Lensmeyer
Keyword(s):  
Gas Chromatography ◽  
Quantitative Determination ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Serum Concentrations ◽  
Single Extraction ◽  
Qualitative And Quantitative ◽  
Gas Chromatographic Method ◽  
Isothermal Gas

Abstract A rapid, simple, accurate, and precise isothermal gas-chromatographic method is introduced for determination of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone) in serum. A single extraction of 2 ml of serum, without derivative formation, will give adequate sensitivity for quantitation of therapeutic serum concentrations of the drug within 15 min. The method is free of interferences from biological substances, as well as from commonly used drugs. A non-drug internal standard compensates for variables in extraction, injection, and instrumental changes during analysis. The coefficient of variation, day-to-day, is 5.6%. Mean recovery of added methaqualone was 80%. To compensate for the nonquantitative yield and ensure accurate results, we prepared all analytical methaqualone standards in serum.

scholarly journals Gas Chromatographic Determination of Alachlor in Microencapsulated Formulations: Mini-Collaborative Study

1987 ◽  
Vol 70 (6) ◽  
pp. 1056-1058
Author(s):  
David F Tomkins
Keyword(s):  
Coefficient Of Variation ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Chromatographic Column ◽  
Data Points ◽  
Gas Chromatographic Method ◽  
Isothermal Gas

Abstract An isothermal gas chromatographic method for measuring alachlor in Micro-Tech® (microencapsulated) formulations was tested by 5 collaborators. The samples were prepared in acetone, and alachlor was determined using a gas chromatographic column of 10% SP- 2250 on 100-120 mesh Supelcoport. Di-n-pentylphthalate was used as the internal standard. Collaborators made single determinations on 5 samples distributed as blind duplicates. The mini-collaborative study generated 47 data points. The coefficient of variation (CV„- pooled) was 1.35%, and CVx-pooled was 0.73%. The method was simple to use and did not reveal any interferences in samples tested. The method has been adopted official first action as an AOACCIPAC method.

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