Qualitative and Quantitative Determination of Methaqualone in Serum by Gas Chromatography

1974 ◽  
Vol 20 (2) ◽  
pp. 249-254 ◽  
Author(s):  
M A Evenson ◽  
G L Lensmeyer
Keyword(s):  
Gas Chromatography ◽  
Quantitative Determination ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Serum Concentrations ◽  
Single Extraction ◽  
Qualitative And Quantitative ◽  
Gas Chromatographic Method ◽  
Isothermal Gas

Abstract A rapid, simple, accurate, and precise isothermal gas-chromatographic method is introduced for determination of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone) in serum. A single extraction of 2 ml of serum, without derivative formation, will give adequate sensitivity for quantitation of therapeutic serum concentrations of the drug within 15 min. The method is free of interferences from biological substances, as well as from commonly used drugs. A non-drug internal standard compensates for variables in extraction, injection, and instrumental changes during analysis. The coefficient of variation, day-to-day, is 5.6%. Mean recovery of added methaqualone was 80%. To compensate for the nonquantitative yield and ensure accurate results, we prepared all analytical methaqualone standards in serum.

Gas Chromatographic Determination of N-Butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine and α,α,α-Trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine in Formulations

1971 ◽  
Vol 54 (3) ◽  
pp. 711-712
Author(s):  
Martha Fuzesi
Keyword(s):  
Gas Chromatography ◽  
Quantitative Determination ◽  
Electron Capture ◽  
Chromatographic Method ◽  
Chromatographic Determination ◽  
Electron Capture Detector ◽  
Reference Solution ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method is described for the quantitative determination of N-butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-tolindine and α,α,α-trifluoro-2,6-dinitro-N,N-dipropyI-p-toluidine herbicides in formulations. The sample is extracted with benzene, and equal amounts of sample and reference solution in the same concentration range are analyzed by gas chromatography, using an electron capture detector and an SE-30/Diatoport S column. The method has been applied successfully to laboratory-prepared and commercial samples.

scholarly journals Gas Chromatographic Determination of Alachlor in Microencapsulated Formulations: Mini-Collaborative Study

1987 ◽  
Vol 70 (6) ◽  
pp. 1056-1058
Author(s):  
David F Tomkins
Keyword(s):  
Coefficient Of Variation ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Chromatographic Column ◽  
Data Points ◽  
Gas Chromatographic Method ◽  
Isothermal Gas

Abstract An isothermal gas chromatographic method for measuring alachlor in Micro-Tech® (microencapsulated) formulations was tested by 5 collaborators. The samples were prepared in acetone, and alachlor was determined using a gas chromatographic column of 10% SP- 2250 on 100-120 mesh Supelcoport. Di-n-pentylphthalate was used as the internal standard. Collaborators made single determinations on 5 samples distributed as blind duplicates. The mini-collaborative study generated 47 data points. The coefficient of variation (CV„- pooled) was 1.35%, and CVx-pooled was 0.73%. The method was simple to use and did not reveal any interferences in samples tested. The method has been adopted official first action as an AOACCIPAC method.

Antipyrine metabolism in man: simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography

1980 ◽  
Vol 58 (1) ◽  
pp. 17-21 ◽  
Author(s):  
T. Inaba ◽  
N. E. Fischer
Keyword(s):  
Gas Chromatography ◽  
Simultaneous Determination ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Antipyrine Metabolism ◽  
Drug Oxidation ◽  
Gas Chromatographic Method

A gas chromatographic method was developed to determine metabolites of antipyrine, norantipyrine (NORA), and 4-hydroxyantipyrine in urine using p-methylated NORA as internal standard. This method requires no derivatization and has ample sensitivity to determine these metabolites in urine after ingestion of antipyrine, a compound widely used as a hepatic probe of drug oxidation.

Gas Chromatographic Determination of Isofenphos in Technical and Formulated Products: Collaborative Study

1987 ◽  
Vol 70 (1) ◽  
pp. 55-57
Author(s):  
Daniel E Terry
Keyword(s):  
Thermal Conductivity ◽  
Gas Chromatography ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Flame Ionization ◽  
Coefficients Of Variation ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method for the determination of isofenphos (OFTANOL®) in isofenphos technical and liquid formulations has been developed and collaboratively studied by 11 laboratories. Two technical samples and 2 liquid flowable samples were analyzed after shaking/extracting in methanol which contained diisobutyl phthalate as an internal standard. The extracts were analyzed by gas chromatography using an SP-2100 column and either flame ionization or thermal conductivity detection. Coefficients of variation were 0.57 and 1.27% for the technical and formulated products, respectively. The GC method has been adopted official first action as a AOACCTPAC method.

scholarly journals Determination of Oligofructose, a Soluble Dietary Fiber, by High-Temperature Capillary Gas Chromatography

2000 ◽  
Vol 83 (4) ◽  
pp. 1020-1026 ◽  
Author(s):  
Dirk Joye ◽  
Hubert Hoebregs
Keyword(s):  
Gas Chromatography ◽  
High Temperature ◽  
Sample Preparation ◽  
Quantitative Determination ◽  
Chromatographic Method ◽  
Capillary Column ◽  
Soluble Dietary Fiber ◽  
Flame Ionization ◽  
Gas Chromatographic Method

Abstract A high-temperature capillary gas chromatographic method was developed for the quantitative determination of oligofructose in foods and food products. Sample preparation involves oxymation and silylation of the extracted sugars. The oximetrimethylsilyl derivatives are analyzed on an apolar capillary column, with detection by flame ionization. The method is accurate, with recovery of spiked samples at >96%. Repeatability was excellent; RSD values of 1.1% were obtained. Other common oligosaccharides, such as malto-, isomalto-, and galactooligosaccharides, and levan do not interfere, making the method specific and reliable.

Determination of Glutethimide (Doriden) and Its Metabolites in Biologic Specimens

1968 ◽  
Vol 14 (7) ◽  
pp. 595-609 ◽  
Author(s):  
Irving Sunshine ◽  
Robert Maes ◽  
Rosalie Faracci
Keyword(s):  
Gas Chromatography ◽  
Thin Layer ◽  
Quantitative Determination ◽  
Thin Layer Chromatography ◽  
Chromatographic Method ◽  
Blood Concentrations ◽  
Gas Chromatographic Method ◽  
Clinical Conditions ◽  
Layer Chromatography

Abstract A gas chromatographic method for the quantitative determination of glutethimide was developed. This method was applied to samples obtained from patients who were comatose because of acute glutethimide intoxication. The results obtained from this procedure were compared with those obtained by using an ultraviolet method. The patients’ clinical conditions were assessed and correlated with the blood concentrations of glutethimide. The samples were processed to isolate glutethimide, as well as its metabolites. The metabolites were separated using thin-layer chromatography and were checked for purity by both thin-layer and gas chromatography.

Determination of Menthol in Honey by Gas Chromatography

1993 ◽  
Vol 76 (6) ◽  
pp. 1289-1295 ◽  
Author(s):  
Li Maojuan ◽  
Donald L Nelson ◽  
Peter Sporns
Keyword(s):  
Gas Chromatography ◽  
Room Temperature ◽  
Chromatographic Method ◽  
Steam Distillation ◽  
Internal Standard ◽  
Acarapis Woodi ◽  
Hexane Extraction ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method was developed for the determination of L-menthol in honey at levels as low as 0.1 ppm. The method includes steam distillation and hexane extraction with an internal standard (2,6-dimethylphenol). Beehives treated to control Acarapis woodi over 21 days with 30-60 g L-menthol contained L-menthol residues in honey and beeswax. L-menthol was found only in treated portions of the hive and not later transferred to added honey supers. The highest levels of residues in honey (18 ppm) and beeswax (2790 ppm) were found when pure L-menthol was adsorbed into foam strips placed on top of the hives. L-menthol residues in honey were not reduced by storage in open containers at room temperature for up to 55 days. Untrained panelists could not detect L-menthol in honey until the levels approached 36 ppm.

A Gas-Chromatographic Method for Separating and Measuring Barbiturates and Glutethimide in Blood

1971 ◽  
Vol 17 (10) ◽  
pp. 1024-1027 ◽  
Author(s):  
Ermalinda A Fiereck ◽  
Norbert W Tietz
Keyword(s):  
Quantitative Determination ◽  
Distribution Coefficient ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Free Sample ◽  
The Individual ◽  
Gas Chromatographic Method ◽  
Drug Free

Abstract A gas-chromatographic method is described for the quantitative determination of 11 barbiturates and glutethimide in blood. The extracted barbiturates are methylated and injected into a 7% DC-200 column. Use of methohexital as the internal standard, as well as the addition of standards to a drug-free sample of blood, compensates for losses and for differences in the distribution coefficient of the individual barbiturates, and makes the procedure highly precise and accurate.

Determination of Trifluralin in Formulations by Gas Chromatography

1971 ◽  
Vol 54 (1) ◽  
pp. 125-127
Author(s):  
Larry G Hambleton
Keyword(s):  
Gas Chromatography ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Average Recovery ◽  
Flame Ionization ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method has been developed that is rapid and specific for trifluralin in formulations. The sample is extracted with acetone, an internal standard is added, and the solution is diluted to volume and injected into a gas chromatograph equipped with a flame ionization detector. Three typical trifluralin formulations were analyzed by both the gas chromatographic method and an ultraviolet method. The gas chromatographic method gave an average recovery of 101.2%.

Gas Chromatographic Determination of O,O-Diethyl S-(N-Isopropylcarbamoylmethyl) Phosphorothiolothionate (Prothoate) in Technical Products and Liquid Formulations

1972 ◽  
Vol 55 (6) ◽  
pp. 1336-1338
Author(s):  
Brunetto Bazzi ◽  
Guglielmo Galluzzi ◽  
Luigi Abruzzese
Keyword(s):  
Thermal Conductivity ◽  
Gas Chromatography ◽  
Chromatographic Method ◽  
Concentration Level ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Thermal Conductivity Detector ◽  
Gas Chromatographic Method ◽  
Technical Products

Abstract A gas chromatographic method has been developed for the analysis of O,O-diethyl S-(N-isopropylcarbamoylmethyl) phosphorothiolothionate . The acaricide or a convenient amount of an acaricidal preparation is dissolved in xylene, together with malathion as an internal standard, and analyzed by gas chromatography, using a thermal conductivity detector. The precision (P = 0.05) of the method is ±1.5% of the concentration level.

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