Thioridazine Interferences with Imipramine Metabolism and Measurement

1996 ◽  
Vol 18 (6) ◽  
pp. 729-731 ◽  
Author(s):  
Gary L. Maynard ◽  
Poonam Soni
Keyword(s):  
Imipramine Metabolism

Reappraisal of human CYP isoforms involved in imipramine metabolism

1998 ◽  
Vol 13 (1) ◽  
pp. 44
Author(s):  
E. Koyama ◽  
K. Chiba ◽  
C. Tani ◽  
T. Ishizaki
Keyword(s):  
Cyp Isoforms ◽  
Imipramine Metabolism

Effect of venlafaxine on imipramine metabolism

2000 ◽  
Vol 96 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Lawrence J Albers ◽  
Christopher Reist ◽  
Ryan L Vu ◽  
Ken Fujimoto ◽  
Vural Ozdemir ◽  
...  
Keyword(s):  
Imipramine Metabolism

Imipramine metabolism: pH-Dependent distribution and urinary excretion

1971 ◽  
Vol 12 (2part1) ◽  
pp. 239-244 ◽  
Author(s):  
Lars F. Gram ◽  
Bent Kofod ◽  
Johannes Christiansen ◽  
Ole J. Rafaelsen
Keyword(s):  
Urinary Excretion ◽  
Ph Dependent ◽  
Imipramine Metabolism

Position selective sex difference in imipramine metabolism in rat liver microsomes

1985 ◽  
Vol 34 (6) ◽  
pp. 898-900 ◽  
Author(s):  
Masato Chiba ◽  
Eri Nishihara ◽  
Shoichi Fujita ◽  
Tokuji Suzuki
Keyword(s):  
Sex Difference ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Imipramine Metabolism

Imipramine metabolism in recurrent depressive episodes

1985 ◽  
Vol 8 (2) ◽  
pp. 183-186
Author(s):  
Gary Tollefson ◽  
Roger Valentine ◽  
Michael Garvey ◽  
V.B. Tuason
Keyword(s):  
Depressive Episodes ◽  
Imipramine Metabolism

Age-associated alteration in imipramine metabolism is position selective

1986 ◽  
Vol 35 (15) ◽  
pp. 2628-2630 ◽  
Author(s):  
Masato Chiba ◽  
Shoichi Fujita ◽  
Kenichi Kitani ◽  
Tokuji Suzuki
Keyword(s):  
Imipramine Metabolism

Pharmacogenetics of Agents Acting on the Central Nervous System

1993 ◽  
Vol 6 (1) ◽  
pp. 2-16 ◽  
Author(s):  
Michael W. Jann ◽  
Sara R. Grimsley
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antipsychotic Drugs ◽  
Oxidation Pathway ◽  
Two Agents ◽  
Cytochrome 450 ◽  
The Central Nervous System ◽  
Imipramine Metabolism ◽  
Isozyme System

This article will review the various agents affecting the central nervous system (CNS) such as the analgesics, antidepressants, anticonvulsants, antipsychotics, and benzodiazepines. Most of the research in pharmacogenetics with the CNS agents have been conducted in the antidepressants. The cytochrome 450 IID6 isozyme system has been shown to influence the disposition of the antidepressants and antipsychotics. Amitriptyline metabolism to nortriptyline and nortriptyline conversion to its 10-OH metabolite were shown to be influenced by the IID6 isozyme. Interestingly, imipramine metabolism to desipramine is only partially related to the IID6 isozyme. Biotransformation of imipramine to its 2-OH metabolite was shown to be affected by the IID6 isozyme, but its metabolism to the 10-OH remains to be investigated. Of the antipsychotic drugs, haloperidol and thioridazine are two agents most studied. Haloperidol is converted to a reduced metabolite via a ketone reductase enzyme. The reduced metabolite is oxidized back to Haloperidol. This oxidation pathway was reported to be affected by the IID6 isozyme. Thioridazine metabolism to mesoridazine and conversion of codeine to morphine appear to be also influenced by CP-450 IID6. Other 450 isozymes are reported to be involved with other CNS agents.

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