Two Years Follow Up after Conversion 1:1 from Twice to Once-Daily Tacrolimus in Liver Transplantation: Quality of Life, Patientsʼ Compliance and Drug Efficacy Evaluation

2012 ◽  
Vol 94 (10S) ◽  
pp. 47
Author(s):  
L. Toti ◽  
T. M. Manzia ◽  
R. Angelico ◽  
P. Ciano ◽  
D. Sforza ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Drug Efficacy ◽  
Efficacy Evaluation ◽  
Once Daily

scholarly journals Observation of the Improvement in Nocturnal Asthma Symptoms with Administration of Once Daily Sustained Released Theophylline

2018 ◽  
Vol 9 (2) ◽  
pp. 74-77
Author(s):  
Mesbahul Karim Ruble ◽  
AKM Rafiqul Bari ◽  
Amar Biswas ◽  
Md Khairul Anam ◽  
Mahbub E Khuda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sustained Release ◽  
Pulmonary Function Tests ◽  
Persistent Asthma ◽  
Nocturnal Asthma ◽  
Once Daily ◽  
Asthma Symptoms ◽  
Sustained Release Theophylline

Objective: The aims and objective of this study to observe the improvement in Nocturnal Asthma symptoms and Quality of Life (QoL) with administration of once daily sustained release theophylline preparation.Background: Nocturnal symptoms are a common part of the asthma. Nocturnal asthma is defined by a drop in forced expiratory volume in 1 second (FEV1) of at least 15% between bedtime and awakening in patients with clinical and physiologic evidence of asthma, which may include improvement in QoL.Methodology: The patient with Chronic Persistent Asthma, both sex, age >18 to 50 years of age and preferably patients with nocturnal exacerbations were included in the study. All patients were diagnosed on the basis of clinical history, physical examination, chest X-ray and pulmonary function tests, in accordance with the clinical criteria for the diagnosis by the GINA. The recruitment period was between March 2017 and August 2017 Shaheed Suhrawardy Medical College Hospital, Dhaka.Results: It was observed that 65(92.85%) was found exacerbation free night and 5(7.15%) patients were found exacerbation with sustained release Theophylline. There are significantly improved qualities of life between 1st follow up to 2nd follow up, 3rd follow up and 4th follow up p<0.001 which was statistically significant. Spirometry test was gradually improved between 1st visit of FEV1 to 2nd, 3rd and 4th visit of FEV1, (p<0.001) that was statistically significant.Conclusion: Most of the patients were found exacerbation free night. There are significantly improved quality of life between 1st follow up to 2nd follow up, 3rd follow up and 4th follow up in Spirometry test. The value of FEV1 was gradually improve in the lst visit, 2nd, 3rd and 4th visit with sustained release Theophylline.J Shaheed Suhrawardy Med Coll, December 2017, Vol.9(2); 74-77

scholarly journals Effectiveness of Naloxegol in Patients With Cancer Pain Suffering From Opioid-Induced Constipation

2021 ◽  
Author(s):  
Antoine Lemaire ◽  
Yoann Pointreau ◽  
Bérengère Narciso ◽  
François-Xavier Piloquet ◽  
Viorica Braniste ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Pain ◽  
Real Life ◽  
Oral Morphine ◽  
Inadequate Response ◽  
Once Daily ◽  
Patients With Cancer ◽  
Pain Patients

Abstract Purpose Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly aimed to assess in real-life conditions the efficacy and safety of naloxegol in cancer pain patients, and the evolution of their quality of life. Methods A non-interventional, 4-week follow-up study was conducted in 24 French oncology and pain centers between 2018 and 2019. Eligible patients were aged ≥ 18 years, treated with opioids for cancer-pain, and started naloxegol for OIC with inadequate response to laxatives. The rate of the response to naloxegol (primary criterion) was assessed at W4. The evolution of quality of life was measured using the Patient Assessment of Constipation Quality of Life (PAC-QOL). Results A total of 124 patients were included (mean age: 62 ± 12 years; ECOG ≤ 2: 79%; primary cancer: lung 18%, breast 16%, prostate 11%, head and neck 9%, digestive 9%...; metastatic stage: 80%). At inclusion, the median opioid dosage was 60 mg of oral-morphine or equivalent. At W4, the response rate was 73.4% (95% CI [63.7%-83.2%]) and 62.9% (95% CI [51.5%-74.2%]) of patients had a clinically relevant change in quality of life (decrease in PAC-QOL score ≥ 0.5 point). Adverse events related to naloxegol were reported in 8% of patients (7% with gastrointestinal events; one serious diarrhea). Conclusion This real-world study shows that naloxegol is effective and well tolerated in cancer pain patients with OIC and that their quality of life improves under treatment.

scholarly journals Liver Transplantation for Unresectable Metastases from Colon Adenocarcinoma

2017 ◽  
Vol 10 (3) ◽  
pp. 808-813 ◽  
Author(s):  
Luis Armando Caicedo ◽  
Diego Buitrago ◽  
Laura S. Thomas ◽  
Jorge I. Villegas ◽  
Mauricio Duque ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Case Report ◽  
Liver Disease ◽  
Colon Adenocarcinoma ◽  
Colorectal Metastases ◽  
Different Types ◽  
Unresectable Metastases

Liver transplantation is an option that improves quality of life and prolongs life expectancy in patients with different types of liver disease. Liver transplantation is controversial for colorectal metastases and is not recommended in clinical practice guidelines. In this case report, we present, to our knowledge, the first liver transplantation for colorectal metastases conducted in Colombia, with a successful follow-up of more than 2 years. Patients with these characteristics who underwent liver transplantation experience reduced mortality and exponentially improved quality of life.

Quality of life after adult living donor liver transplantation: A longitudinal prospective follow-up study

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Junichi Togashi ◽  
Yasuhiko Sugawara ◽  
Nobuhisa Akamatsu ◽  
Sumihito Tamura ◽  
Noriyo Yamashiki ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Follow Up Study
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