Association of Kidney Graft Loss With Posttransplant Presence of HLA Antibodies Detected By Single Antigen Testing.

2014 ◽  
Vol 98 ◽  
pp. 506-507
Author(s):  
C. Suesal ◽  
G. Opelz
Keyword(s):  
Graft Loss ◽  
Kidney Graft ◽  
Hla Antibodies ◽  
Single Antigen ◽  
Antigen Testing

Association of Kidney Graft Loss with Posttransplant Presence of Strong HLA Antibodies Detected by Luminex Single Antigen Testing

2012 ◽  
Vol 94 (10S) ◽  
pp. 62
Author(s):  
C. Süsal ◽  
B. Döhler ◽  
A. Ruhenstroth ◽  
S. Scherer ◽  
T. H. Tran ◽  
...  
Keyword(s):  
Graft Loss ◽  
Kidney Graft ◽  
Hla Antibodies ◽  
Single Antigen ◽  
Antigen Testing

Association of Kidney Graft Loss With De Novo Produced Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by Single Antigen Testing

2015 ◽  
Vol 99 (9) ◽  
pp. 1976-1980 ◽  
Author(s):  
Caner Süsal ◽  
Daniel Wettstein ◽  
Bernd Döhler ◽  
Christian Morath ◽  
Andrea Ruhenstroth ◽  
...  
Keyword(s):  
De Novo ◽  
Graft Loss ◽  
Kidney Graft ◽  
Hla Antibodies ◽  
Single Antigen ◽  
Antigen Testing

No Association of Kidney Graft Loss With Human Leukocyte Antigen Antibodies Detected Exclusively by Sensitive Luminex Single-Antigen Testing: A Collaborative Transplant Study Report

2011 ◽  
Vol 91 (8) ◽  
pp. 883-887 ◽  
Author(s):  
Caner Süsal ◽  
Jörg Ovens ◽  
Khaled Mahmoud ◽  
Bernd Döhler ◽  
Sabine Scherer ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Graft Loss ◽  
Human Leukocyte ◽  
Kidney Graft ◽  
Leukocyte Antigen ◽  
Study Report ◽  
Single Antigen ◽  
Antigen Testing

scholarly journals Pretransplant human leukocyte antigen antibodies detected by single-antigen bead assay are a risk factor for long-term kidney graft loss even in the absence of donor-specific antibodies

2016 ◽  
Vol 29 (9) ◽  
pp. 988-998 ◽  
Author(s):  
Rudolf Richter ◽  
Caner Süsal ◽  
Stefanie Köhler ◽  
Sara Qidan ◽  
Alicia Schödel ◽  
...  
Keyword(s):  
Risk Factor ◽  
Human Leukocyte Antigen ◽  
Graft Loss ◽  
Human Leukocyte ◽  
Kidney Graft ◽  
Specific Antibodies ◽  
Leukocyte Antigen ◽  
Single Antigen ◽  
Donor Specific Antibodies

scholarly journals Posttransplant Allosensitization in Low Immunological Risk Kidney and Kidney-Pancreas Graft Recipients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Jorge Malheiro ◽  
Sandra Tafulo ◽  
Leonídio Dias ◽  
La Salete Martins ◽  
Isabel Fonseca ◽  
...  
Keyword(s):  
Risk Factor ◽  
Graft Loss ◽  
Graft Function ◽  
Kidney Graft ◽  
Hla Antibodies ◽  
Luminex Assay ◽  
Screening Protocol ◽  
Antibody Positivity ◽  
Cox Analysis ◽  
Pancreas Graft

Introduction. Posttransplantation allosensitization prevalence and effect on kidney grafts outcomes remain unsettled.Methods. Between 2007 and 2012, 408 patients received a primary kidney graft (with 68 patients also receiving a pancreas graft) after a negative cytotoxic crossmatch. All patients had a pretransplant negative anti-HLA screening and 0% panel reactive antibodies. We analyzed retrospectively the results of anti-HLA antibodies screening by Luminex assay, performed between 6 and 24 months after transplant, and searched for the risk factors for antibody positivity and its impact on kidney graft outcomes.Results. Anti-HLA antibodies prevalence at 6 months was 17.4%. Previous steroid-insensitive acute rejection was the only risk factor for both anti-HLA classes detected antibodies. Antithymocyte globulin induction was also a risk factor for anti-HLA-I antibodies. Antibody positivity status was associated with reduced graft function at 12 months and graft survival at 5 years (91.5% versus 96.4%,P=0.03). In multivariable Cox analysis, delayed graft function (HR = 6.1,P<0.01), HLA mismatches>3 (HR = 10.2,P=0.03), and antibody positivity for anti-HLA class II (HR = 5.1,P=0.04) or class I/II (HR = 13.8,P<0.01) were independent predictors of graft loss.Conclusions. Allosensitization against HLA classII±Iafter transplant was associated with adverse kidney graft outcomes. A screening protocol seems advisable within the first year in low immunological risk patients.

scholarly journals Serum complement inactivation unveiled prepregnancy donor-specific HLA antibodies leading to postpartum kidney graft loss

2015 ◽  
Vol 28 (5) ◽  
pp. 623-625 ◽  
Author(s):  
Arcangelo Nocera ◽  
Michela Cioni ◽  
Augusto Tagliamacco ◽  
Patrizia Comoli ◽  
Annalisa Innocente ◽  
...  
Keyword(s):  
Graft Loss ◽  
Kidney Graft ◽  
Serum Complement ◽  
Hla Antibodies

scholarly journals Impact of Early Pancreatic Graft Loss on Outcome after Simultaneous Pancreas–Kidney Transplantation (SPKT)—A Landmark Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3237
Author(s):  
Lukas Johannes Lehner ◽  
Robert Öllinger ◽  
Brigitta Globke ◽  
Marcel G. Naik ◽  
Klemens Budde ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Type I ◽  
Kidney Graft ◽  
Landmark Analysis ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation ◽  
Pancreas Graft

(1) Background: Simultaneous pancreas–kidney transplantation (SPKT) is a standard therapeutic option for patients with diabetes mellitus type I and kidney failure. Early pancreas allograft failure is a complication potentially associated with worse outcomes. (2) Methods: We performed a landmark analysis to assess the impact of early pancreas graft loss within 3 months on mortality and kidney graft survival over 10 years. This retrospective single-center study included 114 adult patients who underwent an SPKT between 2005 and 2018. (3) Results: Pancreas graft survival rate was 85.1% at 3 months. The main causes of early pancreas graft loss were thrombosis (6.1%), necrosis (2.6%), and pancreatitis (2.6%). Early pancreas graft loss was not associated with reduced patient survival (p = 0.168) or major adverse cerebral or cardiovascular events over 10 years (p = 0.741) compared to patients with functioning pancreas, after 3 months. Moreover, kidney graft function (p = 0.494) and survival (p = 0.461) were not significantly influenced by early pancreas graft loss. (4) Conclusion: In this study, using the landmark analysis technique, early pancreas graft loss within 3 months did not significantly impact patient or kidney graft survival over 10 years.

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