A direct comparison of cytolytic T-lymphocyte responses to Melan-A peptides in vitro: differential immunogenicity of Melan-A27-35 and Melan-A26-35

2000 ◽  
Vol 10 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Q. Chen ◽  
H. Jackson ◽  
J. Cebon ◽  
P. Gibbs ◽  
I. D. Davis ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytolytic T Lymphocyte ◽  
Lymphocyte Responses

Characterization of a factor(s) which synergizes with recombinant interleukin 2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro

1988 ◽  
Vol 111 (1) ◽  
pp. 39-54 ◽  
Author(s):  
Henry L. Wong ◽  
Darien E. Wilson ◽  
James C. Jenson ◽  
Philip C. Familletti ◽  
Donna L. Stremlo ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Interleukin 2 ◽  
Cytolytic T Lymphocyte ◽  
Recombinant Interleukin 2 ◽  
Lymphocyte Responses

scholarly journals Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

1978 ◽  
Vol 148 (2) ◽  
pp. 352-359 ◽  
Author(s):  
P Billings ◽  
S J Burakoff ◽  
M E Dorf ◽  
B Benacerraf
Keyword(s):  
T Lymphocyte ◽  
Mixed Lymphocyte Reaction ◽  
Bone Marrow Cells ◽  
Spleen Cells ◽  
Host Genotype ◽  
F1 Hybrid ◽  
Cytolytic T Lymphocyte ◽  
Lymphocyte Responses

Bone marrow cells from C3H (H-2k) mice, a strain that does not exhibit cross-reactive lysis of trinitrophenyl (TNP)-modified allogeneic targets, were allowed to mature in heavily irradiated (B6 times C3H)F1 (H-2b/k) recipients, an F1 hybrid that does demonstrate cross-reactive lysis. Spleen cells from these chimeric mice were removed after 3-4 mo and by H-2 typing shown to be of C3H origin. These cells were found to be tolerant to B6 alloantigens by mixed lymphocyte reaction and cell-mediated cytotoxicity and, when stimulated in vitro with TNP-modified syngeneic cells, now cross-reactively lysed TNP-modified allogeneic targets. These studies demonstrate that the host environment where T cells differentiate influences the specificity of the primary cytolytic T-lymphocyte (CTL) response to TNP-modified syngeneic antigens.

scholarly journals Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

1978 ◽  
Vol 148 (2) ◽  
pp. 341-350 ◽  
Author(s):  
P Billings ◽  
S J Burakoff ◽  
M E Dorf ◽  
B Benacerraf
Keyword(s):  
T Lymphocyte ◽  
Inbred Mouse ◽  
Cross Reactivity ◽  
Mouse Strains ◽  
Gene Control ◽  
F1 Hybrid ◽  
Cytolytic T Lymphocyte ◽  
Lymphocyte Responses ◽  
Hybrid Mice

The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.

scholarly journals Sendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.

1980 ◽  
Vol 152 (6) ◽  
pp. 1805-1810 ◽  
Author(s):  
J P Lake ◽  
M E Andrew ◽  
C W Pierce ◽  
T J Braciale
Keyword(s):  
T Lymphocyte ◽  
Nude Mice ◽  
Sendai Virus ◽  
Cytotoxic T Lymphocyte ◽  
Target Cells ◽  
Self Recognition ◽  
Parental Haplotype ◽  
Lymphocyte Responses ◽  
Ctl Responses

The in vitro secondary cytotoxic T lymphocyte (CTL) response to Sendai virus-treated stimulator cells by primed spleen cells from thymus gland-grafted nude mice was examined. BALB/c (H-2d) nude mice grafted with allogeneic C57BL/10 (H-2b) thymus glands developed CTL responses directed exclusively to Sendai virus-infected H-2d target cells. (C57BL/6 X BALB/c)F1 nude mice grafted with thymus glands of either parent developed CTL responses preferentially against infected target cells expressing the MHC antigens present in the parental thymus graft, but also had detectable activity for infected target cells of the parental haplotype not expressed in the thymus. These results provide evidence against the concept that self recognition by MHC-restricted CTL is directed exclusively by the MCH type of the thymus.

In vitro effects of malathion and O,O,S-trimethyl phosphorothioate on cytotoxic T-lymphocyte responses

1985 ◽  
Vol 24 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Kathleen E. Rodgers ◽  
Marcia H. Grayson ◽  
Toshiko Imamura ◽  
Bruce H. Devens
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
In Vitro Effects ◽  
Lymphocyte Responses

Glucuronoxylomannan of Cryptococcus neoformans exacerbates in vitro yeast cell growth by interleukin 10-dependent inhibition of CD4+ T lymphocyte responses

2003 ◽  
Vol 222 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Regis Mariano Andrade ◽  
Geisy Monteiro Almeida ◽  
George Alexandre DosReis ◽  
Cleonice Alves Melo Bento
Keyword(s):  
Cell Growth ◽  
Yeast Cell ◽  
Cryptococcus Neoformans ◽  
T Lymphocyte ◽  
Interleukin 10 ◽  
Dependent Inhibition ◽  
Lymphocyte Responses
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