Effects of Magnesium Administration on Brain Edema and Blood–Brain Barrier Breakdown After Experimental Traumatic Brain Injury in Rats

2003 ◽  
Vol 15 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Figen Esen ◽  
Tulin Erdem ◽  
Damla Aktan ◽  
Rivaze Kalayci ◽  
Nahit Cakar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown ◽  
Experimental Traumatic Brain Injury

scholarly journals Microenvironmental Variations After Blood-Brain Barrier Breakdown in Traumatic Brain Injury

2021 ◽  
Vol 14 ◽  
Author(s):  
Yue Hu ◽  
Weiwei Tao
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Cerebral Metabolism ◽  
Brain Barrier ◽  
Toxic Substances ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Inflammatory Molecules ◽  
Blood Brain Barrier Breakdown

Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB) breakdown is considered to be one of the initial changes. Further, the microenvironmental alteration following TBI-induced BBB breakdown can be multi-scaled, constant, and dramatic. The microenvironmental variations after disruption of BBB includes several pathological changes, such as cerebral blood flow (CBF) alteration, brain edema, cerebral metabolism imbalances, and accumulation of inflammatory molecules. The modulation of the microenvironment presents attractive targets for TBI recovery, such as reducing toxic substances, inhibiting inflammation, and promoting neurogenesis. Herein, we briefly review the pathological alterations of the microenvironmental changes following BBB breakdown and outline potential interventions for TBI recovery based on microenvironmental modulation.

The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats

2013 ◽  
Vol 19 (4) ◽  
pp. 294-298 ◽  
Author(s):  
Ismet Topcu ◽  
Gul Gumuser ◽  
Eda Bayram ◽  
Feray Aras ◽  
Ismail Cetin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain
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