THE ROLE OF DOPAMINE RECEPTORS OF THE LATERAL HYPOTHALAMUS-ZONA INCERTA REGION (LH-ZI) IN THE NEUROLEPTIC-INDUCED CATALEPSY

1992 ◽  
Vol 3 (Supplement) ◽  
pp. 74
Author(s):  
J WARDAS ◽  
S WOLFARTH
1990 ◽  
Vol 506 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Krystyna Ossowska ◽  
Jadwiga Wardas ◽  
Krystyna Golembiowska ◽  
Stanislaw Wolfarth

2013 ◽  
Vol 109 (10) ◽  
pp. 2505-2516 ◽  
Author(s):  
Fu-Zen Shaw ◽  
Yi-Fang Liao ◽  
Ruei-Feng Chen ◽  
Yu-Hsing Huang ◽  
Rick C. S. Lin

The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior.


1991 ◽  
Vol 105 (4) ◽  
pp. 525-529 ◽  
Author(s):  
Ella M. Nikulina ◽  
Julia A. Skrinskaya ◽  
Nina K. Popova

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