BRADYKININ GENERATION AS A POSSIBLE CAUSAL FACTOR OF GENERALIZED EDEMA FORMATION FOLLOWING EXTRACORPOREAL CIRCULATION IN PEDIATRIC HEART SURGERY.

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 141
Author(s):  
Christiane Neuhof ◽  
Friedhelm Dapper ◽  
Olaf Walter ◽  
Jürgen Bauer ◽  
Edwin Fink ◽  
...  
1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.


1967 ◽  
Vol 18 (03/04) ◽  
pp. 634-646 ◽  
Author(s):  
N Thurnherr

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.


Circulation ◽  
1996 ◽  
Vol 94 (5) ◽  
pp. 1063-1067 ◽  
Author(s):  
Robert E. Shaddy ◽  
Dixie D. Hunter ◽  
Karen A. Osborn ◽  
Linda M. Lambert ◽  
L. LuAnn Minich ◽  
...  

Circulation ◽  
2000 ◽  
Vol 102 (Supplement 3) ◽  
pp. III-179-III-182 ◽  
Author(s):  
J. P. Breinholt ◽  
J. A. Hawkins ◽  
L. M. Lambert ◽  
T. C. Fuller ◽  
T. Profaizer ◽  
...  

1996 ◽  
Vol 22 (5) ◽  
pp. 492-494 ◽  
Author(s):  
C. Bartels ◽  
B. Hadzik ◽  
M. Abel ◽  
B. Roth

2017 ◽  
Vol 69 (11) ◽  
pp. 591
Author(s):  
Meena Nathan ◽  
Brielle Tishler ◽  
Kimberlee Gauvreau ◽  
Gregory S. Matte ◽  
Robert J. Howe ◽  
...  

2018 ◽  
Vol 30 (1) ◽  
pp. 62-68
Author(s):  
Punkaj Gupta ◽  
Mallikarjuna Rettiganti ◽  
Andrew Wilcox ◽  
Mai-Anh Vuong-Dac ◽  
Jeffrey M. Gossett ◽  
...  

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