scholarly journals Effects of activated protein C on coagulation and fibrinolysis in rabbits with endotoxin induced acute lung injury

2008 ◽  
Vol 121 (24) ◽  
pp. 2561-2565 ◽  
Author(s):  
Hang-yong HE ◽  
Chen WANG ◽  
Bao-sen PANG
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein C ◽  
Activated Protein C ◽  
Coagulation And Fibrinolysis

ACTIVATED PROTEIN C REDUCES COMBINED BURN AND SMOKE INHALATION-INDUCED ACUTE LUNG INJURY IN MICE BY INHIBITING EXCESSIVE PRODUCTION OF NITRIC OXIDE

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A24 ◽  
Author(s):  
Akio Mizutani ◽  
Kazunori Murakami ◽  
Kenji Okajima ◽  
Takayuki Noguchi ◽  
Sachiko Mizutani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein C ◽  
Activated Protein C ◽  
Smoke Inhalation

Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury

2007 ◽  
Vol 33 (12) ◽  
pp. 2199-2206 ◽  
Author(s):  
Jean-Christophe Richard ◽  
Fabienne Bregeon ◽  
Véronique Leray ◽  
Didier Le Bars ◽  
Nicolas Costes ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Blood Flow ◽  
Protein C ◽  
Cytokine Production ◽  
Activated Protein C

Activated Protein C Attenuates Acute Lung Injury and Apoptosis in a Hyperoxic Animal Model

Shock ◽  
2009 ◽  
pp. 1
Author(s):  
Ahmad W Husari ◽  
Aline Khayat ◽  
Haitham Awdeh ◽  
Hadi Hatoum ◽  
Michel Nasser ◽  
...  
Keyword(s):  
Animal Model ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein C ◽  
Activated Protein C

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury

2006 ◽  
Vol 291 (3) ◽  
pp. L307-L311 ◽  
Author(s):  
Lorraine B. Ware ◽  
Eric Camerer ◽  
Karen Welty-Wolf ◽  
Marcus J. Schultz ◽  
Michael A. Matthay
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein C ◽  
Distress Syndrome ◽  
Coagulation Cascade ◽  
Inflammatory Conditions ◽  
Ventilator Induced Lung Injury ◽  
Substantial Progress ◽  
Coagulation And Fibrinolysis ◽  
Made In

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

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