Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation

2000 ◽  
Vol 9 (4) ◽  
pp. 435-439 ◽  
Author(s):  
Takashi Ohuchi ◽  
Masashi Yanagisawa ◽  
Cheryl E. Gariepy
Keyword(s):  
Volume Regulation ◽  
Extracellular Volume ◽  
Receptor Signaling ◽  
Endothelin B Receptor ◽  
Cardiovascular Homeostasis ◽  
Endothelin B ◽  
Renal Tubular

PTEN overexpression attenuates angiogenic processes of endothelial cells by blockade of endothelin-1/endothelin B receptor signaling

2012 ◽  
Vol 221 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Hsiao-Mei Kuo ◽  
Chun-Yao Lin ◽  
Hing-Chung Lam ◽  
Pey-Ru Lin ◽  
Hoi-Hung Chan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Receptor Signaling ◽  
Endothelin B Receptor ◽  
Endothelin 1 ◽  
Endothelin B

Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma

Oncogene ◽  
2021 ◽  
Author(s):  
Alexander Schäfer ◽  
Benedicte Haenig ◽  
Julie Erupathil ◽  
Panja Strickner ◽  
Daniela Sabato ◽  
...  
Keyword(s):  
Mapk Pathway ◽  
Receptor Signaling ◽  
Endothelin B Receptor ◽  
Endothelin B

An Improved Procedure for the Preparation of the Endothelin-B-Receptor Ligand Sarafotoxin 6c

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S290-S291 ◽  
Author(s):  
Chantal Langlois ◽  
Sophie Tessier ◽  
Alexandre Brkovic ◽  
Alain Fournier
Keyword(s):  
Receptor Ligand ◽  
Endothelin B Receptor ◽  
Endothelin B

ALTERATIONS IN ENDOTHELIN B RECEPTOR SITES IN CAVERNOSAL TISSUE OF DIABETIC RABBITS: POTENTIAL RELEVANCE TO THE PATHOGENESIS OF ERECTILE DYSFUNCTION

1997 ◽  
Vol 158 (5) ◽  
pp. 1966-1972 ◽  
Author(s):  
M.E. Sullivan ◽  
M.R. Dashwood ◽  
C.S. Thompson ◽  
J.R. Muddle ◽  
D.P. Mikhailidis ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Endothelin B Receptor ◽  
Receptor Sites ◽  
Endothelin B ◽  
Diabetic Rabbits

scholarly journals Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1α

Blood ◽  
2008 ◽  
Vol 112 (3) ◽  
pp. 856-865 ◽  
Author(s):  
Nitin Patel ◽  
Caryn S. Gonsalves ◽  
Punam Malik ◽  
Vijay K. Kalra
Keyword(s):  
Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Receptor Expression ◽  
Placenta Growth Factor ◽  
Promoter Regions ◽  
Endothelin B Receptor ◽  
Endothelin 1 ◽  
Hypoxia Inducible Factor 1Α ◽  
Endothelin B ◽  
Potent Vasoconstrictor

Abstract Pulmonary hypertension (PHT) develops in sickle cell disease (SCD) and is associated with high mortality. We previously showed that erythroid cells produce placenta growth factor (PlGF), which activates monocytes to induce proinflammatory cytochemokines, contributing to the baseline inflammation and severity in SCD. In this study, we observed that PlGF increased expression of endothelin-1 (ET-1) and endothelin-B receptor (ET-BR) from human pulmonary microvascular endothelial cells (HPMVECs) and monocytes, respectively. PlGF-mediated ET-1 and ET-BR expression occurred via activation of PI-3 kinase, reactive oxygen species and hypoxia inducible factor-1α (HIF-1α). PlGF increased binding of HIF-1α to the ET-1 and ET-BR promoters; this effect was abrogated with mutation of hypoxia response elements in the promoter regions and HIF-1α siRNA and confirmed by chromatin immunoprecipitation analysis. Furthermore, PlGF-mediated ET-1 release from HPMVECs and ET-BR expression in monocytes creates a PlGF–ET-1–ET-BR loop, leading to increased expression of MCP-1 and IL-8. Our studies show that PlGF-induced expression of the potent vasoconstrictor ET-1 and its cognate ET-BR receptor occur via activation of HIF-1α, independent of hypoxia. PlGF levels are intrinsically elevated from the increased red cell turnover in SCD and in other chronic anemia (eg, thalassemia) and may contribute to inflammation and PHT seen in these diseases.

Novel mutation of Endothelin-B receptor gene in Waardenburg–Hirschsprung disease

2005 ◽  
Vol 21 (12) ◽  
pp. 960-963 ◽  
Author(s):  
Surasak Sangkhathat ◽  
Piyawan Chiengkriwate ◽  
Takeshi Kusafuka ◽  
Sakda Patrapinyokul ◽  
Masahiro Fukuzawa
Keyword(s):  
Novel Mutation ◽  
Receptor Gene ◽  
Hirschsprung Disease ◽  
Endothelin B Receptor ◽  
Endothelin B

Mutation Analysis of Endothelin-B Receptor Gene in Patients With Hirschsprung Disease in Taiwan

2008 ◽  
Vol 46 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Yu-Cheng Lin ◽  
Hong-Shiee Lai ◽  
Wen-Ming Hsu ◽  
Ping-Ing Lee ◽  
Huey-Ling Chen ◽  
...  
Keyword(s):  
Mutation Analysis ◽  
Receptor Gene ◽  
Hirschsprung Disease ◽  
Endothelin B Receptor ◽  
Endothelin B
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