Validation of [13C]urea breath test for Helicobacter pylori using a simple gas chromatograph-mass selective detector

1998 ◽  
Vol 10 (7) ◽  
pp. 569-572 ◽  
Author(s):  
How-Sung Lee ◽  
Kok-Ann Gwee ◽  
Le-Yan Teng ◽  
Jin-Yong Kang ◽  
Khay-Guan Yeoh ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Urea Breath Test ◽  
Gas Chromatograph ◽  
Mass Selective Detector ◽  
Selective Detector ◽  
13C Urea Breath Test

scholarly journals Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Doron Boltin ◽  
Zohar Levi ◽  
Tsachi Tsadok Perets ◽  
Hemda Schmilovitz-Weiss ◽  
Rachel Gingold-Belfer ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Treatment Success ◽  
Population Based ◽  
Urea Breath Test ◽  
First Line Therapy ◽  
13C Urea Breath Test ◽  
Helicobacter Pylori Treatment ◽  
H Pylori ◽  
First Time

Background. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Methods. Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included. In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H. pylori test, we excluded patients > 45 years and those with a previous C13-UBT. Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. C13-UBT was positive in 48,509 (51.3%) subjects. A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%). The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01). Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01). Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01). Conclusions. The superiority in H. pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant. Further studies should examine the physiological and microbiological basis for this finding.

Diagnosis of Helicobacter pylori Infection by Means of Reduced-Dose 13C-Urea Breath Test and Early Sampling of Exhaled Breath

2013 ◽  
Vol 57 (5) ◽  
pp. 607-611 ◽  
Author(s):  
Sylmara L.M. Pacheco ◽  
Silvio K. Ogata ◽  
Rodrigo S. Machado ◽  
Francy Reis da Silva Patrício ◽  
Mario L.E. Pardo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Exhaled Breath ◽  
Reduced Dose ◽  
13C Urea Breath Test

13C-urea breath test for the diagnosis of Helicobacter pylori infection before treatment: is citric acid necessary?

2000 ◽  
Vol 32 (1) ◽  
pp. 20-24 ◽  
Author(s):  
J.P. Gisbert ◽  
M.A. Vazquez ◽  
I. Jimenez ◽  
A.I. Cruzado ◽  
D. Carpio ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Citric Acid ◽  
Breath Test ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
13C Urea Breath Test
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