Discrimination of Dementia With Lewy Bodies From Alzheimer Disease and Parkinson Disease Using the Clock Drawing Test

2003 ◽  
Vol 16 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Deborah A. Cahn-Weiner ◽  
Karren Williams ◽  
Janet Grace ◽  
Geoffrey Tremont ◽  
Holly Westervelt ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Parkinson Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test

scholarly journals The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies

2018 ◽  
Vol 45 (5-6) ◽  
pp. 308-317 ◽  
Author(s):  
Leonie J.M. Vergouw ◽  
Mariet Salomé ◽  
Anke G. Kerklaan ◽  
Christiaan Kies ◽  
Gerwin Roks ◽  
...  
Keyword(s):  
Nursing Home ◽  
Dementia With Lewy Bodies ◽  
Prognostic Markers ◽  
Cox Regression ◽  
Medical Center ◽  
Lewy Bodies ◽  
Nursing Home Admission ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test

Aims: To determine whether the pentagon copying test (PCT) and the clock drawing test (CDT) are associated with nursing home admission or survival in dementia with Lewy bodies (DLB). Methods: The PCT and/or the CDT were retrospectively collected from 103 clinically diagnosed probable DLB patients at a university medical center and general hospital. Patients with high versus low scores on these tests were compared. Results: Kaplan-Meier analysis showed that patients with a low score on the PCT had a shorter time to nursing home admission than patients with a high score (log-rank χ2 = 6.1, p = 0.01). Patients with a low score on the PCT or the CDT had a shorter survival than patients with a high score (log-rank χ2 = 5.4, p = 0.02, and log-rank χ2 = 11.2, p < 0.001, respectively). Cox regression analyses showed the same associations with an HR of 2.2 (95% CI 1.2–4.1) for the PCT and an HR of 2.9 (95% CI 1.6–5.4) for the CDT. Conclusion: The PCT and the CDT may function as prognostic markers in DLB. This finding is clinically relevant as these tests can be applied easily in the clinical setting and can provide valuable prognostic information. Furthermore, it may improve disease management and patient selection for research purposes.

Validity and Clinical Utility of Different Clock Drawing Test Scoring Systems in Multiple Forms of Dementia

2018 ◽  
Vol 31 (3) ◽  
pp. 114-122 ◽  
Author(s):  
Diana Duro ◽  
Miguel Tábuas-Pereira ◽  
Sandra Freitas ◽  
Beatriz Santiago ◽  
Maria Amália Botelho ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Lewy Bodies ◽  
Scoring Systems ◽  
Cognitive Screening ◽  
Clock Drawing Test ◽  
Screening Measure ◽  
Clock Drawing ◽  
Drawing Test ◽  
Tertiary Center ◽  
Cognitive Screening Measure

The Clock Drawing Test (CDT) has a known potential for the detection of cognitive impairment in populations with dementia, especially Alzheimer disease (AD). Our aim was to compare the clinical utility of 3 CDT scoring systems (Rouleau, Cahn, and Babins) in several pathologies with cognitive compromise from a tertiary center memory clinic. We selected patients with a clinical diagnosis of mild stage AD, behavioral variant frontotemporal dementia (FTD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and Parkinson disease with dementia (PDD). The results showed significant differences between the several diagnoses with the following pattern of results: AD, DLB < FTD, VaD, PDD. Qualitative analysis of clock drawing errors confirmed the stimulus-bound response as a hallmark of AD, while conceptual deficit was significantly more prevalent in patients with AD and DLB. Our results supported the CDT potential as a cognitive screening measure for mild dementia, particularly sensitive to AD and DLB, especially when we used the Cahn scoring system and its analysis of qualitative errors.

scholarly journals Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia

2015 ◽  
Vol 23 (2) ◽  
pp. 141-148 ◽  
Author(s):  
David R. Whitfield ◽  
Julie Vallortigara ◽  
Amani Alghamdi ◽  
Tibor Hortobágyi ◽  
Clive Ballard ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Parkinson Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Utility of Autonomic Function Tests to Differentiate Dementia with Lewy Bodies and Parkinson Disease with Dementia from Alzheimer Disease

2017 ◽  
Vol 79 (1-2) ◽  
pp. 27-32 ◽  
Author(s):  
Shuta Toru ◽  
Tadashi Kanouchi ◽  
Takanori Yokota ◽  
Yosuke Yagi ◽  
Akira Machida ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Parkinson Disease ◽  
Dementia With Lewy Bodies ◽  
Autonomic Function ◽  
Lewy Bodies ◽  
Sympathetic Skin Response ◽  
Tilt Test ◽  
Autonomic Function Tests ◽  
Function Tests ◽  
Skin Response

Objective: We studied autonomic disturbance in patients with dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD), Alzheimer disease (AD), to determine whether autonomic function tests can be used to distinguish these disorders. Methods: Autonomic function was tested in 56 patients with DLB, 37 patients with PDD, and 59 patients with AD by using the sympathetic skin response, coefficient of variation in R-R interval, the head-up tilt test, serum norepinephrine concentration, and 123I-meta-iodobenzylguanidine cardiac scintigraphy. Symptoms of autonomic dysfunction, such as constipation, urinary symptoms, and orthostatic hypotension, were also noted. Results: The groups did not differ on baseline characteristics other than those associated with Parkinsonism and dementia. All patients with DLB and PDD had some dysautonomia, whereas rates were much lower for patients with AD (19%). Significantly more DLB and PDD patients than AD patients showed abnormalities on autonomic function tests. Conclusions: Autonomic function tests might be quite useful to distinguish DLB and PDD from AD.

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