Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial *

2004 ◽  
Vol 32 (11) ◽  
pp. 2207-2218 ◽  
Author(s):  
Pierre-Francois Laterre ◽  
Howard Levy ◽  
Gilles Clermont ◽  
Daniel E. Ball ◽  
Rekha Garg ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Hospital Mortality ◽  
Resource Use ◽  
Protein C ◽  
Activated Protein C ◽  
Prowess Trial

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2018 ◽  
pp. 61-67
Author(s):  
Anna M. Ward ◽  
Richard M. Pino
Keyword(s):  
Severe Sepsis ◽  
Study Design ◽  
Protein C ◽  
Clinical Case ◽  
Activated Protein C ◽  
Efficacy And Safety ◽  
Prowess Trial ◽  
Study Intervention ◽  
Prowess Study

This chapter provides a summary of the landmark study known as the PROWESS Study. Does treatment with DAA reduce the rate of death from any cause among patients with severe sepsis? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. The PROWESS trial demonstrated a mortality benefit for DAA among patients with severe sepsis. However, the subsequent ADDRESS, RESOLVE, and PROWESS-SHOCK trials did not demonstrate a benefit of the medication, thus calling the results of PROWESS into question.

scholarly journals A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care

Critical Care ◽  
2008 ◽  
Vol 12 (5) ◽  
pp. 429 ◽  
Author(s):  
Christopher J Longo ◽  
Daren K Heyland ◽  
Harold N Fisher ◽  
Robert A Fowler ◽  
Claudio M Martin ◽  
...  
Keyword(s):  
Resource Use ◽  
Protein C ◽  
Activated Protein C ◽  
Follow Up Study ◽  
Related Quality ◽  
Long Term Follow Up ◽  
Health Related

ACTIVATED PROTEIN C IMPROVES SURVIVAL IN SEVERE SEPSIS PATIENTS WITH ELEVATED TROPONIN.

2007 ◽  
Vol 55 (1) ◽  
pp. S290
Author(s):  
J. John ◽  
A. Awab ◽  
D. Norman ◽  
G. T. Kinasewitz
Keyword(s):  
Severe Sepsis ◽  
Protein C ◽  
Activated Protein C ◽  
Elevated Troponin
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