scholarly journals Clearance Kinetics and External Dosimetry of 131I-Labeled Murine and Humanized Monoclonal Antibody A33 in Patients with Colon Cancer: Radiation Safety Implications

2009 ◽  
Vol 96 (5) ◽  
pp. 550-557 ◽  
Author(s):  
Lawrence T. Dauer ◽  
Daniel C. Boylan ◽  
Matthew J. Williamson ◽  
Jean St. Germain ◽  
Steven M. Larson
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer ◽  
Radiation Safety ◽  
Humanized Monoclonal Antibody ◽  
Clearance Kinetics

scholarly journals Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 79170-79186 ◽  
Author(s):  
Guang Wu ◽  
Dongbum Kim ◽  
Byoung Kwon Park ◽  
Sangkyu Park ◽  
Ji-Hee Ha ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer ◽  
Lung Metastasis ◽  
Peptide Vaccine ◽  
Mouse Lung ◽  
Humanized Monoclonal Antibody ◽  
Metastasis Model ◽  
Specific Peptide

Radioimmunotherapy of colon cancer with an improved humanized monoclonal antibody design

2002 ◽  
Vol 54 (2) ◽  
pp. 98 ◽  
Author(s):  
R.F Meredith ◽  
A Forero ◽  
M Khazaeli ◽  
M Carpenter ◽  
J Schlom ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer ◽  
Humanized Monoclonal Antibody ◽  
Antibody Design

scholarly journals Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4127
Author(s):  
Aline de Cristo Soares Alves ◽  
Franciele Aline Bruinsmann ◽  
Silvia Stanisçuaski Guterres ◽  
Adriana Raffin Pohlmann
Keyword(s):  
Monoclonal Antibody ◽  
Physicochemical Characterization ◽  
Vascular Endothelial ◽  
Organic Nanoparticles ◽  
Humanized Monoclonal Antibody ◽  
Angiogenesis Process ◽  
Endothelial Growth Factor ◽  
Drug Pharmacokinetics

Bevacizumab (BCZ) is a recombinant humanized monoclonal antibody against the vascular endothelial growth factor, which is involved in the angiogenesis process. Pathologic angiogenesis is observed in several diseases including ophthalmic disorders and cancer. The multiple administrations of BCZ can cause adverse effects. In this way, the development of controlled release systems for BCZ delivery can promote the modification of drug pharmacokinetics and, consequently, decrease the dose, toxicity, and cost due to improved efficacy. This review highlights BCZ formulated in organic nanoparticles providing an overview of the physicochemical characterization and in vitro and in vivo biological evaluations. Moreover, the main advantages and limitations of the different approaches are discussed. Despite difficulties in working with antibodies, those nanocarriers provided advantages in BCZ protection against degradation guaranteeing bioactivity maintenance.

scholarly journals Reduction of Respiratory Syncytial Virus (RSV) in Tracheal Aspirates in Intubated Infants by Use of Humanized Monoclonal Antibody to RSV F Protein

1998 ◽  
Vol 178 (6) ◽  
pp. 1555-1561 ◽  
Author(s):  
Richard Malley ◽  
John DeVincenzo ◽  
Octavio Ramilo ◽  
Penelope H. Dennehy ◽  
H. Cody Meissner ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Respiratory Syncytial Virus ◽  
F Protein ◽  
Humanized Monoclonal Antibody ◽  
Syncytial Virus ◽  
Tracheal Aspirates

MONOCLONAL ANTIBODY RADIOIMMUNODETECTION OF HUMAN DERIVED COLON CANCER

1982 ◽  
Vol 17 (4) ◽  
pp. S34
Author(s):  
Richard Wahl ◽  
Gordon Philpott ◽  
Charles W. Parker
Keyword(s):  
Monoclonal Antibody ◽  
Colon Cancer

scholarly journals A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

2011 ◽  
Vol 162 (8) ◽  
pp. 1855-1870 ◽  
Author(s):  
EG Stefanich ◽  
DM Danilenko ◽  
H Wang ◽  
S O'Byrne ◽  
R Erickson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Lymphocytes ◽  
Humanized Monoclonal Antibody ◽  
Antibody Targeting
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