PB2044 DIAGNOSIS OF IRON DEFICIENCY ANAEMIA AND PARENTERAL IRON THERAPY: CLINICAL AUDIT IN A DISTRICT GENERAL HOSPITAL

Background: Iron deficiency anaemia (IDA) is a common haematological complication with potentially serious clinical consequences that may require intravenous iron therapy. Parenteral iron therapy results faster and higher replenishment of iron stores and correction of Haemoglobin (Hb) levels with better compliance. The study was to compare the efficacy of intravenous ferric carboxymaltose with intravenous iron sucrose to treat iron deficiency anaemia. Methods: 188 patients were included in the study. 100 patients were given iron sucrose. After a 25 mg test dose on the first infusion only, this was given at a dose of 300 mg by intravenous infusion diluted in 100 ml of normal saline, every alternate day. 88 patients were treated with ferric carboxymaltose at a dose of 500 mg diluted in 100 ml of normal saline by intravenous infusion. Hb level and serum Ferritin of both groups were done before iron therapy and 3 weeks after iron therapy. Results: The mean±SD rise of haemoglobin concentration 3 weeks after iron therapy in iron sucrose group was 11.0±0.61 g/dL, while in ferric carboxymaltose group was 11.2±0.64 g/dL. The mean±SD ferritin 3 weeks after iron therapy in iron sucrose group was 76.0±14.28 ng/mL, while in ferric carboxymaltose group was 80.0±15.16 ng/mL. No serious adverse events were reported in either the ferric carboxymaltose group or iron sucrose group. Conclusions: Ferric carboxymaltose causes higher rise in Hb level as compared to parenteral iron sucrose.

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Audit of the investigation of iron deficiency anaemia in a district general hospital, with sample guidelines for future practice

Postgraduate Medical Journal ◽

10.1136/pmj.76.894.218 ◽

2000 ◽

Vol 76 (894) ◽

pp. 218-222 ◽

Cited By ~ 13

Author(s):

J M T Willoughby

Keyword(s):

Iron Deficiency ◽

General Hospital ◽

Iron Deficiency Anaemia ◽

District General Hospital ◽

Deficiency Anaemia ◽

Future Practice

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Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia

10.1002/14651858.cd001444 ◽

2001 ◽

Cited By ~ 19

Author(s):

Susana Martins ◽

Stuart Logan ◽

Ruth E Gilbert

Keyword(s):

Cognitive Function ◽

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Iron Therapy ◽

Psychomotor Development ◽

Deficiency Anaemia

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The tongue and oesophagus in iron-deficiency anaemia and the effect of iron therapy

Journal of Clinical Pathology ◽

10.1136/jcp.14.6.603 ◽

1961 ◽

Vol 14 (6) ◽

pp. 603-609 ◽

Cited By ~ 22

Author(s):

I. M. Baird ◽

O. G. Dodge ◽

F. J. Palmer ◽

R. J. Wawman

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Iron Therapy ◽

Deficiency Anaemia

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Comparative study of efficacy and safety of parenteral iron sucrose versus ferric carboxymaltose in treatment of postpartum iron deficiency anaemia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20215083 ◽

2021 ◽

Vol 11 (1) ◽

pp. 100

Author(s):

Ganesh N. Dakhle ◽

Mrunalini V. Kalikar ◽

Rujuta P. Fuke ◽

Anisha S. Parmarthi ◽

Mrunalini K. Chokhandre

Keyword(s):

Iron Deficiency ◽

Serum Ferritin ◽

Iron Deficiency Anaemia ◽

Maximum Dose ◽

Iron Sucrose ◽

Ferric Carboxymaltose ◽

Care Hospital ◽

Deficiency Anaemia ◽

Iron Stores ◽

Parenteral Iron

Background: Postpartum anaemia often leads to multiple clinical complications in mother as well as infant and iron supplementation with parenteral iron is the preferred treatment modality. The present study was planned to compare the efficacy and tolerability of IV iron sucrose and IV ferric carboxymaltose in treatment of postpartum iron deficiency anaemia.Methods: This randomized, parallel, open label, prospective 4-weeks study was conducted from June 2019 to December 2020 in women with postpartum anaemia admitted to obstetrics and gynaecology inpatient department of a tertiary care hospital. Women with postpartum iron deficiency anaemia (N=60) were randomly divided into two groups; receiving Injection iron sucrose (N=30, maximum dose 500 mg) or Injection ferric carboxymaltose (N=30, maximum dose 500 mg). Change in haemoglobin and serum ferritin levels from baseline to the end of 2 and 4 weeks of treatment were evaluated.Results: The results showed early, sustained and significant increase in the haemoglobin levels in both the groups. However, the difference was not significant between groups (p=0.2). Evaluation of replenishment of iron stores (serum ferritin) showed improvement in both the groups, however in FCM group the rise was found to be significant (p<0.05).Conclusions: FCM in a lower dose of 500mg was found to be safe and effective in significantly improving haemoglobin concentration as well as in replenishing iron stores in patients with postpartum anaemia.

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