Vaginal and Rectal Topical Microbicide Development: Safety and Efficacy of 1.0% Savvy (C31G) in the Pigtailed Macaque

2006 ◽  
Vol 33 (11) ◽  
pp. 691-695 ◽  
Author(s):  
Dorothy L. Patton ◽  
Yvonne T. Cosgrove Sweeney ◽  
Jennifer E. Balkus ◽  
Sharon L. Hillier
Keyword(s):  
Safety And Efficacy ◽  
Microbicide Development ◽  
Topical Microbicide

scholarly journals Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

2009 ◽  
Vol 106 (15) ◽  
pp. 6099-6104 ◽  
Author(s):  
B. R. O'Keefe ◽  
F. Vojdani ◽  
V. Buffa ◽  
R. J. Shattock ◽  
D. C. Montefiori ◽  
...  
Keyword(s):  
Entry Inhibitor ◽  
Safety And Efficacy ◽  
Hiv 1 ◽  
Topical Microbicide

scholarly journals High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 2965 ◽  
Author(s):  
Ignacio Rodriguez-Izquierdo ◽  
Samanta Gasco ◽  
Maria Angeles Muñoz-Fernández
Keyword(s):  
Vaginal Microbiome ◽  
Preventive Effect ◽  
Carbosilane Dendrimers ◽  
Sexually Transmitted ◽  
Essential Step ◽  
Carbosilane Dendrimer ◽  
Microbicide Development ◽  
Topical Microbicide

Anionic carbosilane dendrimers such as G2-S16 are very effective in preventing HSV-2 infection both in vitro and in vivo. We present the main achievements obtained for the G2-S16 dendrimer in vivo, especially related to its efficacy against HSV-2 infection. Moreover, we discuss the mechanisms by which the G2-S16 dendrimer applied vaginally as a topical microbicide has been demonstrated to be safe and harmless for the vaginal microbiome balance, as both conditions present an essential step that has to be overcome during microbicide development. This review points to the marked protective effect of the G2-S16 dendrimer against sexually transmitted HSV-2 infection, supporting its role as a possible microbicide against HSV-2 infection.

scholarly journals A Summary of Preclinical Topical Microbicide Rectal Safety and Efficacy Evaluations in a Pigtailed Macaque Model

2009 ◽  
Vol 36 (6) ◽  
pp. 350-356 ◽  
Author(s):  
Dorothy L. Patton ◽  
Yvonne T. Cosgrove Sweeney ◽  
Kathleen J. Paul
Keyword(s):  
Safety And Efficacy ◽  
Macaque Model ◽  
Topical Microbicide

805: Safety and Efficacy of Gentamycin Bladder Irrigations in Complex Urologic Patients

2005 ◽  
Vol 173 (4S) ◽  
pp. 218-218
Author(s):  
William DeFoor ◽  
Denise Ferguson ◽  
Susan Mashni ◽  
Deborah Reeves ◽  
Lisa Creelman ◽  
...  
Keyword(s):  
Safety And Efficacy

Fractional Ablative CO2 Laser Displays Safety and Efficacy

2007 ◽  
Vol 38 (5) ◽  
pp. 1-33
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Co2 Laser ◽  
Safety And Efficacy

Abstract #1233: 9-Month Safety and Efficacy of Saroglitazar in Diabetic Dyslipidemia

2015 ◽  
Vol 21 ◽  
pp. 291-292
Author(s):  
Shashank Joshi ◽  
Jothydev Kesavadev ◽  
Sudhir Bhandari ◽  
Banshi Saboo ◽  
Ashok Jaiswal ◽  
...  
Keyword(s):  
Diabetic Dyslipidemia ◽  
Safety And Efficacy
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