Does Multimodal Analgesia With Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, or Selective Cyclooxygenase-2 Inhibitors and Patient-Controlled Analgesia Morphine Offer Advantages Over Morphine Alone? Meta-Analyses of Randomized Trials

2006 ◽  
Vol 50 (5) ◽  
pp. 266-267
Author(s):  
&NA;
Keyword(s):  
Randomized Trials ◽  
Multimodal Analgesia ◽  
Cyclooxygenase 2 ◽  
Patient Controlled Analgesia ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Meta Analyses ◽  
Cyclooxygenase 2 Inhibitors

scholarly journals Cardiovascular and cerebrovascular risk with nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors: latest evidence and clinical implications

2017 ◽  
Vol 8 (6) ◽  
pp. 173-182 ◽  
Author(s):  
Andrea Fanelli ◽  
Daniela Ghisi ◽  
Pierangelo Lora Aprile ◽  
Francesco Lapi
Keyword(s):  
Term Treatment ◽  
Cyclooxygenase 2 ◽  
Thrombotic Risk ◽  
Long Term Treatment ◽  
Pressure Development ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
High Doses ◽  
The Right ◽  
Meta Analyses

Observational studies and meta-analyses have shown that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs), especially when prescribed at high doses for long periods of time, can potentially increase the risk of cardiovascular diseases. The increased thrombotic risk related to the use of NSAIDs is mainly due to their cyclooxygenase 2 selectivity. The dosage use, the formulation selected and the duration of the therapy are other factors that can significantly impact on the cardiovascular risk. In order to minimize the risk, prescription of the right drug based on the patient’s features and the different safety profiles of several NSAIDs that are available on the market is key for their appropriate administration. Despite the baseline cardiovascular and gastrointestinal risk of each patient, monitoring of patients is suggested for increases in blood pressure, development of edema, deterioration of renal function, or gastrointestinal bleeding during long-term treatment with NSAIDs.

Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors

2006 ◽  
Vol 82 (8) ◽  
pp. 206-212 ◽  
Author(s):  
Maria Odete Esteves Hilário ◽  
Maria Teresa Terreri ◽  
Cláudio Arnaldo Len
Keyword(s):  
Cyclooxygenase 2 ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Cyclooxygenase 2 Inhibitors
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