Paper 15: Skeletal Muscle Heavy-Chain Polypeptide 3 and Myosin Binding Protein H in the Pubococcygeus Muscle in Patients with and without Pelvic Organ Prolapse

2005 ◽  
Vol 11 (Supplement 1) ◽  
pp. S7-S8
Author(s):  
A F. Hundley ◽  
L Yuan ◽  
A G. Visco
Keyword(s):  
Skeletal Muscle ◽  
Pelvic Organ Prolapse ◽  
Heavy Chain ◽  
Binding Protein ◽  
Pelvic Organ ◽  
Myosin Binding Protein ◽  
Myosin Binding

Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

2011 ◽  
Vol 436 (2) ◽  
pp. 437-445 ◽  
Author(s):  
Zhe Chen ◽  
Tong-Jin Zhao ◽  
Jie Li ◽  
Yan-Song Gao ◽  
Fan-Guo Meng ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Contraction ◽  
Binding Protein ◽  
High Energy ◽  
Functional Coupling ◽  
Muscle Type ◽  
Myosin Binding Protein ◽  
Slow Skeletal Muscle ◽  
Myosin Binding

Muscle contraction requires high energy fluxes, which are supplied by MM-CK (muscle-type creatine kinase) which couples to the myofibril. However, little is known about the detailed molecular mechanisms of how MM-CK participates in and is regulated during muscle contraction. In the present study, MM-CK is found to physically interact with the slow skeletal muscle-type MyBPC1 (myosin-binding protein C1). The interaction between MyBPC1 and MM-CK depended on the creatine concentration in a dose-dependent manner, but not on ATP, ADP or phosphocreatine. The MyBPC1–CK interaction favoured acidic conditions, and the two molecules dissociated at above pH 7.5. Domain-mapping experiments indicated that MM-CK binds to the C-terminal domains of MyBPC1, which is also the binding site of myosin. The functional coupling of myosin, MyBPC1 and MM-CK is further corroborated using an ATPase activity assay in which ATP expenditure accelerates upon the association of the three proteins, and the apparent Km value of myosin is therefore reduced. The results of the present study suggest that MyBPC1 acts as an adaptor to connect the ATP consumer (myosin) and the regenerator (MM-CK) for efficient energy metabolism and homoeostasis.

scholarly journals Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients

2014 ◽  
Vol 1842 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Antonio Conti ◽  
Nilo Riva ◽  
Mariasabina Pesca ◽  
Sandro Iannaccone ◽  
Carlo V. Cannistraci ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amyotrophic Lateral Sclerosis ◽  
Binding Protein ◽  
Myosin Binding Protein ◽  
Myosin Binding ◽  
Lateral Sclerosis

scholarly journals Cardiac Myosin Binding Protein-C Phosphorylation in a β-Myosin Heavy Chain Background

Circulation ◽  
2009 ◽  
Vol 119 (9) ◽  
pp. 1253-1262 ◽  
Author(s):  
Sakthivel Sadayappan ◽  
James Gulick ◽  
Raisa Klevitsky ◽  
John N. Lorenz ◽  
Michelle Sargent ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Protein C ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding

Skeletal Muscle–Specific Myosin Binding Protein-H Is Expressed in Purkinje Fibers of the Cardiac Conduction System

1997 ◽  
Vol 80 (5) ◽  
pp. 665-672 ◽  
Author(s):  
Tatiana Alyonycheva ◽  
Leona Cohen-Gould ◽  
Christiana Siewert ◽  
Donald A. Fischman ◽  
Takashi Mikawa
Keyword(s):  
Skeletal Muscle ◽  
Binding Protein ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Cardiac Conduction System ◽  
Purkinje Fibers ◽  
Myosin Binding Protein ◽  
Myosin Binding
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