Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain

Spine ◽  
2016 ◽  
Vol 41 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Bárbara Zille de Queiroz ◽  
Daniele Sirineu Pereira ◽  
Renata Antunes Lopes ◽  
Diogo Carvalho Felício ◽  
Juscelio Pereira Silva ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Plasma Levels ◽  
The Elderly ◽  
Low Back ◽  
Acute Low Back Pain ◽  
Mediators Of Inflammation

Onset of analgesic effect and plasma levels of controlled-release tramadol (Tramadol Contramid once-a-day) 200-mg tablets in patients with acute low back pain

2018 ◽  
Vol 4 (5) ◽  
pp. 285 ◽  
Author(s):  
Adrian Sarbu, MD ◽  
Florin Radulescu, MD ◽  
Sybil Robertson, BScN ◽  
Sylvie Bouchard, MD, PhD
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Controlled Release ◽  
Pain Relief ◽  
Plasma Levels ◽  
Immediate Release ◽  
Pharmacokinetic Profile ◽  
Low Back ◽  
Acute Low Back Pain ◽  
Therapeutic Threshold

Background and Aims: Tramadol hydrochloride, a centrally acting, synthetic analgesic, has been available in Europe since 1977 in a variety of formulations and in the United States since 1995. Its clinical efficacy was established in a variety of painful conditions (cancer pain, neuropathic pain, and osteoarthritis). Nonetheless, little published data exist regarding the relationship between analgesic onset and minimum therapeutic plasma levels. Tramadol Contramid* once-a-day (OAD) demonstrates a pharmacokinetic profile with a sharp initial absorption slope similar to the pharmacokinetic profile of the immediate- release tramadol, suggesting that both the immediaterelease and the once-daily (Contramid) formulation may produce a similar onset of analgesia.Methods: This multicentre, open-label, single-dose study examined the pharmacokinetics/pharmacodynamics of Tramadol Contramid OAD in patients with acute low back pain. Patients who signed informed consent were screened and washed-out of prior analgesics. Patients received one dose of Tramadol Contramid OAD 200 mg. The patients indicated the time of onset of pain relief (stopwatch method). Ratings of pain intensity and pain relief and pharmacokinetic samples were taken prior to dosing, at the onset of pain relief, and 3 and 6 hours postdose. No rescue medication was permitted until the end of the study (6-hour postdose). Adverse events were monitored throughout the study.Results: Forty of the 47 patients enrolled completed the study. Onset of perceptible pain relief was achieved within 1 hour for the majority of patients and at plasma levels, suggesting a therapeutic threshold between 50 and 100 ng/mL. Two patients did not experience any pain relief.Conclusions: The results of this exploratory study suggest that similar to immediate-release tramadol, onset of analgesia for this controlled-release formulation of tramadol (Tramadol Contramid OAD) occurs within 1 hour at a mean therapeutic threshold concentration of 56 ± 38 ng/mL.

scholarly journals Disability in older adults with acute low back pain: the study Back Complaints in the Elderly – (Brazil)

2017 ◽  
Vol 21 (5) ◽  
pp. 365-371 ◽  
Author(s):  
Alessandra Regina Silva Araujo Aguiar ◽  
Giane Amorim Ribeiro-Samora ◽  
Leani Souza Maximo Pereira ◽  
Larissa Birro Godinho ◽  
Marcella Guimarães Assis
Keyword(s):  
Older Adults ◽  
Low Back Pain ◽  
Back Pain ◽  
The Elderly ◽  
Low Back ◽  
Acute Low Back Pain

Low Back Pain in Commercial Airline Pilots

2020 ◽  
Vol 91 (12) ◽  
pp. 940-947
Author(s):  
Matthias Albermann ◽  
Maria Lehmann ◽  
Christian Eiche ◽  
Joachim Schmidt ◽  
Johannes Prottengeier
Keyword(s):  
Risk Factors ◽  
Low Back Pain ◽  
Back Pain ◽  
Online Survey ◽  
German Population ◽  
Low Back ◽  
Airline Pilots ◽  
Acute Low Back Pain ◽  
Commercial Airline ◽  
Negative Effect

BACKGROUND: In their working life, airline pilots are exposed to particular risk factors that promote nonspecific low back pain (LBP). Because of the varying incidence internationally, we evaluated the point prevalences of acute, subacute, and chronic nonspecific LBP, as well as the current prevalences in German airline pilots. Furthermore, we compared the prevalence to the general German population and to European counterparts.METHODS: An anonymous online survey of 698 participating German airline pilots was evaluated. The impairment between groups was analyzed. Prevalences from our data were compared to existing data.RESULTS: The following point prevalences were found: 8.2% acute, 2.4% subacute, 82.7% chronic LBP; 74.1% of all individuals were suffering from current LBP when answered the questionnaire. A total time spent flying greater than 600 h within the last 12 mo was significantly related to acute nonspecific LBP. Individuals with any type of LBP were significantly impaired compared to those unaffected. It was found that German airline pilots suffer more often from current LBP than the general population and have a higher point prevalence of total LBP than their European counterparts.CONCLUSIONS: The evaluation showed a surprisingly high, previously unidentified, prevalence of nonspecific LBP in German airline pilots. Why German airline pilots suffer more often from LBP remains uncertain. The number of flying hours appears to have a negative effect on developing acute low back pain, but causation cannot be concluded. Other risk factors could not be confirmed.Albermann M, Lehmann M, Eiche C, Schmidt J, Prottengeier J. Low back pain in commercial airline pilots. Aerosp Med Hum Perform. 2020; 91(12):940947.

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