Antibiotic dosing during sustained low-efficiency dialysis: Special considerations in adult critically ill patients*

2011 ◽  
Vol 39 (3) ◽  
pp. 560-570 ◽  
Author(s):  
Kimberly N. Bogard ◽  
Nicole T. Peterson ◽  
Troy J. Plumb ◽  
Michael W. Erwin ◽  
Patrick D. Fuller ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Low Efficiency ◽  
Antibiotic Dosing

scholarly journals Antibiotic Dosing in Sustained Low-Efficiency Dialysis in Critically Ill Patients

2018 ◽  
Vol 5 ◽  
pp. 205435811879222 ◽  
Author(s):  
Sidharth Kumar Sethi ◽  
Vinod Krishnappa ◽  
Nisha Nangethu ◽  
Paul Nemer ◽  
Lawrence A. Frazee ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Low Efficiency ◽  
Antibiotic Dosing

Pharmacokinetic and Pharmacodynamic Characteristics of Vancomycin and Meropenem in Critically Ill Patients Receiving Sustained Low-efficiency Dialysis

2020 ◽  
Vol 42 (4) ◽  
pp. 625-633 ◽  
Author(s):  
Maura Salaroli Oliveira ◽  
Anna Silva Machado ◽  
Elisa Teixeira Mendes ◽  
Lucas Chaves ◽  
Lauro Vieira Perdigão Neto ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Low Efficiency

Antibiotic dosing in critically ill patients with acute kidney injury

2011 ◽  
Vol 7 (4) ◽  
pp. 226-235 ◽  
Author(s):  
Rachel F. Eyler ◽  
Bruce A. Mueller
Keyword(s):  
Acute Kidney Injury ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Kidney Injury ◽  
Antibiotic Dosing

scholarly journals Antibiotic Dosing for Critically Ill Adult Patients Receiving Intermittent Hemodialysis, Prolonged Intermittent Renal Replacement Therapy, and Continuous Renal Replacement Therapy: An Update

2019 ◽  
Vol 54 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Brian M. Hoff ◽  
Jenana H. Maker ◽  
William E. Dager ◽  
Brett H. Heintz
Keyword(s):  
Renal Function ◽  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Response To Therapy ◽  
Intermittent Hemodialysis ◽  
Intermittent Renal Replacement Therapy ◽  
Antibiotic Dosing

Objective: To summarize current antibiotic dosing recommendations in critically ill patients receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy (PIRRT), and continuous renal replacement therapy (CRRT), including considerations for individualizing therapy. Data Sources: A literature search of PubMed from January 2008 to May 2019 was performed to identify English-language literature in which dosing recommendations were proposed for antibiotics commonly used in critically ill patients receiving IHD, PIRRT, or CRRT. Study Selection and Data Extraction: All pertinent reviews, selected studies, and references were evaluated to ensure appropriateness for inclusion. Data Synthesis: Updated empirical dosing considerations are proposed for antibiotics in critically ill patients receiving IHD, PIRRT, and CRRT with recommendations for individualizing therapy. Relevance to Patient Care and Clinical Practice: This review defines principles for assessing renal function, identifies RRT system properties affecting drug clearance and drug properties affecting clearance during RRT, outlines pharmacokinetic and pharmacodynamic dosing considerations, reviews pertinent updates in the literature, develops updated empirical dosing recommendations, and highlights important factors for individualizing therapy in critically ill patients. Conclusions: Appropriate antimicrobial selection and dosing are vital to improve clinical outcomes. Dosing recommendations should be applied cautiously with efforts to consider local epidemiology and resistance patterns, antibiotic dosing and infusion strategies, renal replacement modalities, patient-specific considerations, severity of illness, residual renal function, comorbidities, and patient response to therapy. Recommendations provided herein are intended to serve as a guide in developing and revising therapy plans individualized to meet a patient’s needs.

Antibiotic Dosing in Critically Ill Patients

2010 ◽  
pp. 128-128
Author(s):  
Marta Ulldemolins, ◽  
Jason Roberts, ◽  
Julie Varghese, ◽  
Jeffrey Lipman
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Antibiotic Dosing

scholarly journals Drug Dosing Considerations in Critically Ill Patients Receiving Continuous Renal Replacement Therapy

Pharmacy ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 18 ◽  
Author(s):  
Soo Min Jang ◽  
Sergio Infante ◽  
Amir Abdi Pour
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Patient Specific ◽  
Therapeutic Drug ◽  
Intermittent Hemodialysis ◽  
Drug Dosing ◽  
Low Efficiency

Acute kidney injury is very common in critically ill patients requiring renal replacement therapy. Despite the advancement in medicine, the mortality rate from septic shock can be as high as 60%. This manuscript describes drug-dosing considerations and challenges for clinicians. For instance, drugs’ pharmacokinetic changes (e.g., decreased protein binding and increased volume of distribution) and drug property changes in critical illness affecting solute or drug clearance during renal replacement therapy. Moreover, different types of renal replacement therapy (intermittent hemodialysis, prolonged intermittent renal replacement therapy or sustained low-efficiency dialysis, and continuous renal replacement therapy) are discussed to describe how to optimize the drug administration strategies. With updated literature, pharmacodynamic targets and empirical dosing recommendations for commonly used antibiotics in critically ill patients receiving continuous renal replacement therapy are outlined. It is vital to utilize local epidemiology and resistance patterns to select appropriate antibiotics to optimize clinical outcomes. Therapeutic drug monitoring should be used, when possible. This review should be used as a guide to develop a patient-specific antibiotic therapy plan.

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