What is Extraocular Cutaneous Sebaceous Carcinoma In Situ?

2010 ◽  
Vol 32 (8) ◽  
pp. 857-858 ◽  
Author(s):  
Dmitry V Kazakov ◽  
Heinz Kutzner ◽  
Dominic V Spagnolo ◽  
Arno Rütten ◽  
Petr Mukensnabl ◽  
...  
Keyword(s):  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

Sebaceous carcinoma in situ as a diagnostic entity. Case report and review of the literature.

2018 ◽  
Vol 2 (2) ◽  
pp. 136-141
Author(s):  
Leart Berdica ◽  
Teona Bushati ◽  
Alfred Aga ◽  
Erisa Kola ◽  
Rustem Celami ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoma In Situ ◽  
Sebaceous Carcinoma ◽  
Review Of The Literature

scholarly journals Sebaceous carcinoma in situ: a case report

2019 ◽  
Vol 3 (1) ◽  
pp. 49
Author(s):  
Taha Cumhan ŞAVLI ◽  
Cem LEBLEBICI ◽  
Ayşe Esra KOKU AKSU
Keyword(s):  
Case Report ◽  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance

2019 ◽  
Vol 73 (3) ◽  
pp. 172-175 ◽  
Author(s):  
Curtis Edward Margo
Keyword(s):  
Clinical Studies ◽  
Clinical Management ◽  
Carcinoma In Situ ◽  
Critical Appraisal ◽  
Sebaceous Carcinoma ◽  
Pagetoid Spread ◽  
Prognostic Importance ◽  
Intraepithelial Spread ◽  
Morphological Patterns

Intraepithelial sebaceous neoplasia in the forms (or subclassification) of pagetoid spread and carcinoma in situ is a common feature of periocular sebaceous carcinoma and is associated with less favourable outcomes. Seminal studies of periocular sebaceous carcinoma in the 1980s indicated that the two patterns of intraepithelial spread had differing influences on prognosis with pagetoid invasion being worse. Later studies reported conflicting results, but careful inspection of those studies revealed considerable variation in what was meant by pagetoid invasion. Different interpretations of pagetoid spread continue, leading to ambiguous results in clinical studies and miscommunication with potential unintended decisions affecting clinical management. This paper reviews the background leading to the frequent interchangeable use of pagetoid spread with in situ sebaceous carcinoma and how this problem confounds interpretation of clinical studies. The author recommends that for effective communication, all morphological patterns of in situ spread of sebaceous carcinoma fall under the term intraepithelial sebaceous neoplasia, which can be accompanied by subclassification whenever desired.

Sebaceous Carcinoma In Situ of the External Auditory Canal

2020 ◽  
Vol 41 (6) ◽  
pp. e765-e766
Author(s):  
Ali Al Khader ◽  
Esra Nsour ◽  
Ayman Hiari
Keyword(s):  
External Auditory Canal ◽  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

Sebaceous Carcinoma In Situ

2010 ◽  
Vol 32 (8) ◽  
pp. 854-855 ◽  
Author(s):  
Jill M Kramer ◽  
Sheng Chen
Keyword(s):  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor

2020 ◽  
Vol 28 (8) ◽  
pp. 888-892
Author(s):  
C. L. Yim ◽  
S. C. Lam ◽  
Hunter Kwok Lai Yuen ◽  
Wah Cheuk
Keyword(s):  
Carcinoma In Situ ◽  
Squamous Carcinoma ◽  
Meibomian Gland ◽  
Sebaceous Carcinoma ◽  
Carcinoma Cells ◽  
Stromal Invasion ◽  
Sebaceous Glands ◽  
Squamous Carcinoma Cells ◽  
Aggressive Tumor

Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with no invasive carcinoma in the underlying sebaceous glands. Early stromal invasion was identified that featured 2 distinctive but focally intermixed populations of sebaceous carcinoma cells and squamous carcinoma cells. The 2 populations of cells exhibited their respective distinct immunophenotype but both showed strong overexpression of p53. This case provides evidence to support the hypothesis that some ocular sebaceous carcinoma may arise from intraepithelial pluripotent stem cells.

Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst

2018 ◽  
Vol 59 (4) ◽  
pp. e310-e311 ◽  
Author(s):  
Albert Wu ◽  
Michelle T Sun ◽  
Sophia Otto ◽  
Shyamala C Huilgol ◽  
Dinesh Selva
Keyword(s):  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

scholarly journals Sebaceous carcinoma in situ as a concept and diagnostic entity.

2017 ◽  
Vol 7 (3) ◽  
pp. 27-31 ◽  
Author(s):  
Miglena Komforti ◽  
Masoud Asgari ◽  
Sheng chen
Keyword(s):  
Carcinoma In Situ ◽  
Sebaceous Carcinoma

scholarly journals Sebaceous carcinoma in situ as a diagnostic entity. Case report and review of the literature.

2018 ◽  
Vol 2 (2) ◽  
pp. 136-141 ◽  
Author(s):  
Leart Bërdica ◽  
Teona Bushati ◽  
Alfred Aga ◽  
Erisa Kola ◽  
Rustem Celami ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoma In Situ ◽  
Histopathological Examination ◽  
Diagnostic Category ◽  
Benign Neoplasm ◽  
Sebaceous Carcinoma ◽  
Review Of The Literature ◽  
General Pathology ◽  
Report Presentation

The concept of carcinoma in situ was first introduced by Broders in 1932 [1] and has been accepted as a well-established notion and diagnostic category in many organs and systems. However, sebaceous carcinoma in situ (SCIS) has not yet been recognized as a concept and diagnostic entity in general pathology or dermatopathology. Such lesions have been commonly misinterpreted as either a benign neoplasm or sebaceous carcinoma. Tumors that do not necessarily arise in pre-existing sebaceous glands are usually invasive at the time of diagnosis, and like their ocular counterparts, can exhibit pagetoid intraepidermal spread. Cases of purely in- situ extraocular sebaceous carcinoma are extremely rare and yet controversial until now.Recognizing sebaceous carcinoma in situ as a valid concept and diagnostic entity that will certainly help to avoid misinterpretation and subsequently under or over treatment of such lesions.In this article, we provide a case report presentation with histopathological examination and a critical review of the literature.

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