Fluorescence In Situ Hybridization (FISH) as an Aid for the Diagnosis of Graft-Versus-Host Disease in Two Multivisceral Organ Transplant Patients

2013 ◽  
Vol 35 (4) ◽  
pp. 496-502
Author(s):  
Christiane Machado ◽  
Rachael Teo ◽  
Nico Mousdicas ◽  
Marco A. Lacerda ◽  
Rodrigo Vianna ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Graft Versus Host Disease ◽  
Organ Transplant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Transplant Patients

Fluorescent in situ hybridization of a skin biopsy: An adjunctive tool to support a diagnosis of graft-versus-host disease

2011 ◽  
Vol 64 (6) ◽  
pp. e113-e114 ◽  
Author(s):  
Josephine Nguyen ◽  
Michael T. Tetzlaff ◽  
Paul J. Zhang ◽  
Xaiowei Xu ◽  
Elizabeth Hexner ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Skin Biopsy ◽  
Graft Versus Host Disease ◽  
Fluorescent In Situ Hybridization ◽  
Host Disease ◽  
Graft Versus Host

Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients

2018 ◽  
Vol 28 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Sonali D. Advani ◽  
Anoma Nellore ◽  
Giorgos Hadjivassiliou ◽  
Devin E. Eckhoff ◽  
Donna Salzman ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C ◽  
Graft Versus Host Disease ◽  
High Dose ◽  
Solid Organ ◽  
Hcv Treatment ◽  
Host Disease ◽  
Graft Versus Host ◽  
Transplant Patients

Graft-versus-host disease (GvHD) is a rare but fatal complication after solid organ transplantation arising in 1% to 2% of cases. We report 2 cases of GvHD after orthotopic liver transplantation. Both patients had a history of hepatitis C virus (HCV) infection prior to transplantation. Both cases presented between 1 and 4 months after transplantation with rash, pancytopenia, and/or diarrhea. Our second case also developed oral and ocular manifestations after liver transplantation, which are more commonly described after stem cell transplantation. Diagnosis in both cases was made by clinical presentation in conjunction with histopathology and flow cytometry. Both patients were treated by increasing immunosuppression with tacrolimus and high-dose steroids. Response to treatment differed based on the degree of pancytopenia. Our case report is distinguished by several factors such as the context of GvHD presentation and the role of HCV treatment. Diagnosis of GvHD is difficult and often delayed due to nonspecific presentation that overlaps with other conditions. Furthermore, the relation between HCV treatment and potential initiation of GvHD in solid organ transplant patients is unclear.

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