Diagnostic Utility of p63 Expression in the Differential Diagnosis of Pagetoid Squamous Cell Carcinoma In Situ and Extramammary Paget Disease

2014 ◽  
Vol 36 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Jason Chang ◽  
Victor G. Prieto ◽  
Martin Sangueza ◽  
Jose A. Plaza
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Diagnostic Utility ◽  
Paget Disease

Extramammary Paget Disease of the Scrotum With Features of Bowen Disease

2004 ◽  
Vol 128 (1) ◽  
pp. 84-86 ◽  
Author(s):  
Adam M. Quinn ◽  
Anna Sienko ◽  
Zane Basrawala ◽  
Steve C. Campbell
Keyword(s):  
Molecular Weight ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Low Molecular Weight ◽  
Paget Disease ◽  
Bowen Disease ◽  
Erythematous Patch

Abstract The scrotum is an uncommon site for the presentation of extramammary Paget disease (EMPD). We describe a case of EMPD that was discovered in a patient who had been previously diagnosed and treated for squamous cell carcinoma in situ of the scrotum 3 years earlier. Pathologic examination of the current scrotectomy specimen revealed an erythematous patch with areas of pale induration. Microscopic examination revealed areas with the characteristic histology of Paget disease adjacent to areas characteristic of Bowen disease. Immunohistochemical findings demonstrated a strong expression of carcinoembryonic antigen, cytokeratin 7, and low-molecular-weight cytokeratins (CAM 5.2) in both of these areas, giving support to the overall diagnosis of EMPD. High-molecular-weight cytokeratins (34βE12) were uncharacteristically expressed in the cytoplasm of the Paget cells with equal or greater strength than in the surrounding keratinocytes, suggesting some degree of squamous differentiation. Very few publications have reported the coexistence of EMPD with squamous cell carcinoma in situ, occurring mostly in the vulva. To our knowledge, our case is the first report of scrotal EMPD with features of Bowen disease. Our findings support the theory that primary EMPD arises multifocally from multipotential epidermal cells.

Monodactylous Longitudinal Melanonychia: A Sign of Bowen’s Disease in Skin of Color

2021 ◽  
Vol 7 (4) ◽  
pp. 306-310
Author(s):  
Natalie M. Williams ◽  
Aderonke O. Obayomi ◽  
Julio A. Diaz-Perez ◽  
Brian W. Morrison
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Nail Plate ◽  
Lateral Aspect ◽  
Case Presentation ◽  
Longitudinal Melanonychia

<b><i>Introduction:</i></b> Monodactylous longitudinal melanonychia (LM) may represent both benign and malignant dermatologic disorders. However, squamous cell carcinoma in situ (SCCis) is not commonly considered in this setting. <b><i>Case Presentation:</i></b> In this report, we present 2 cases of SCCis of the nail matrix in patients with skin of color who presented with monodactylous LM involving the lateral aspect of the nail. <b><i>Conclusion:</i></b> These cases suggest that SCCis should be included in the differential diagnosis for monodactylous LM, especially when involving the lateral nail plate in darker skin.

Factors Influencing Squamous Cell Carcinoma In Situ Recurrence and Implications for Treatment Choice

2018 ◽  
Vol 44 (5) ◽  
pp. 613-620 ◽  
Author(s):  
Andrew J. Matsumoto ◽  
Adam R. Schmitt ◽  
Logan M. Skelley ◽  
Christian L. Baum
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Treatment Choice ◽  
Factors Influencing

Pigmented squamous cell carcinoma in situ of the eyelid

2017 ◽  
Vol 58 (4) ◽  
pp. e275-e276
Author(s):  
Michelle T. Sun ◽  
Saul Rajak ◽  
Craig James ◽  
Shyamala C. Huilgol ◽  
Dinesh Selva
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ

Pigmented Squamous Cell Carcinoma In Situ of the Conjunctiva in 5 Cases

Ophthalmology ◽  
2008 ◽  
Vol 115 (10) ◽  
pp. 1673-1678 ◽  
Author(s):  
Carol L. Shields ◽  
Ajay Manchandia ◽  
Rajeeve Subbiah ◽  
Ralph C. Eagle ◽  
Jerry A. Shields
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ
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