Perianal Application of Glyceryl Trinitrate Ointment Vs Tocopheral Acetate Ointment in the Treatment of Chronic Anal Fissure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jaime Ruiz-Tovar ◽  
Carolina Llavero
The Lancet ◽  
1997 ◽  
Vol 349 (9051) ◽  
pp. 573
Author(s):  
Jonathan N Lund ◽  
John H Scholefield

2011 ◽  
Vol 73 (4) ◽  
pp. 268-277 ◽  
Author(s):  
Leo Francis Tauro ◽  
Vittal V. Shindhe ◽  
P. Sathyamoorthy Aithala ◽  
John J. S. Martis ◽  
H. Divakar Shenoy

1999 ◽  
Vol 42 (8) ◽  
pp. 1000-1006 ◽  
Author(s):  
M. L. Kennedy ◽  
S. Sowter ◽  
H. Nguyen ◽  
D. Z. Lubowski

2021 ◽  
Vol 15 (10) ◽  
pp. 2600-2601
Author(s):  
Imran Sadiq ◽  
Muhammad Javed Shakir ◽  
Ruqqia Naheed Khan ◽  
Muhammad Akhlaq Ahmed ◽  
Syeda Samina Ashfaq ◽  
...  

Background: Anal fissure is a linear painful mucosal tearing in the distal part of anal canal. It extends from dentate to anal edge. Aim: To compare the glyceryltrinitrate ointment and internal lateral sphincterotomy for anal fissure pain relief in acute/chronic pts. Study Design: Prospective study Place and duration of study: Department of Surgery Unit-II, Fatima Memorial Hospital, Shadman Lahore from 1st October 2018 to 31stDecember 2020. Methodology: 40 pts with acute and chronic anal fissure were enrolled. Half of the patients undergo internal lateral sphincterotomy while other opted 0.2% use of glyceryl trinitrate ointment. Each patient was followed for pain, recovery, complications and recurrence until 12 months for internal lateral sphincterotomy and 18 months in glyceryl trinitrate ointment. Results: There were 24 males and 16 females with a mean age of patients as 30±3.2 years. Initial follow-up of patients showed 100% pain and fissure improvement in internal lateral sphincterotomy group as compared to 60% in glyceryl trinitrate ointment group respectively. Conclusion: Internal lateral sphincterotomy is most efficient and reliable procedure in relieving anal fissure pains. Keywords: Anal fissure, Internal lateral sphincterotomy, Glyceryl trinitrate


1970 ◽  
Vol 34 (1) ◽  
pp. 12-15 ◽  
Author(s):  
Md. Ibrahim Siddique ◽  
Khandker Manzoor Murshed ◽  
M.A. Majid

The gold standard surgical treatment of chronic anal fissure is lateral internal sphincterotomy which lowers the resting anal pressure and effectively heals the majority of fissures. Local application of 0.2% glyceryl trinitrate ointment has been used as an agent for chemical sphincterotomy, causing temporary alleviation of sphincter spasm and allowing the fissure to heal without compromising the anal continence. The aim of the present study was to compare the results of surgical sphincterotomy with that of local 0.2% glyceryl trinitrate ointment in the treatment of chronic anal fissure. Seventy adult patients between the age of 18 and 50 years with chronic anal fissure were randomized in a prospective trial to receive either surgical sphincterotomy or 0.2% glyceryl trinitrate ointment locally. Patients were followed up at 2 weeks’ interval for 10 weeks. Symptom relief, fissure healing and continence scores were the outcomes assessed. Six patients were excluded for protocol violations. Surgical sphincterotomy was significantly more effective in providing pain relief and was associated with significantly better fissure healing rates at 6 weeks and 10 weeks (both p0.05). Considering early symptomatic relief, rapid fissure healing and better patient compliance surgical sphincterotomy is the treatment of choice for chronic anal fissure.Keywords: Anal fissure; Glyceryl trinitrate; SphincterotomyDOI: 10.3329/bmrcb.v34i1.1163Bangladesh Med Res Counc Bull 2008; 34: 12-15


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