Comparison of Glyceryl Trinitrate Ointment versus Internal Lateral Sphincterotomy for Anal Fissure Pain Relief

2021 ◽  
Vol 15 (10) ◽  
pp. 2600-2601
Author(s):  
Imran Sadiq ◽  
Muhammad Javed Shakir ◽  
Ruqqia Naheed Khan ◽  
Muhammad Akhlaq Ahmed ◽  
Syeda Samina Ashfaq ◽  
...  
Keyword(s):  
Pain Relief ◽  
Anal Canal ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Distal Part ◽  
Chronic Anal Fissure ◽  
Lateral Sphincterotomy ◽  
Reliable Procedure ◽  
Glyceryl Trinitrate Ointment

Background: Anal fissure is a linear painful mucosal tearing in the distal part of anal canal. It extends from dentate to anal edge. Aim: To compare the glyceryltrinitrate ointment and internal lateral sphincterotomy for anal fissure pain relief in acute/chronic pts. Study Design: Prospective study Place and duration of study: Department of Surgery Unit-II, Fatima Memorial Hospital, Shadman Lahore from 1st October 2018 to 31stDecember 2020. Methodology: 40 pts with acute and chronic anal fissure were enrolled. Half of the patients undergo internal lateral sphincterotomy while other opted 0.2% use of glyceryl trinitrate ointment. Each patient was followed for pain, recovery, complications and recurrence until 12 months for internal lateral sphincterotomy and 18 months in glyceryl trinitrate ointment. Results: There were 24 males and 16 females with a mean age of patients as 30±3.2 years. Initial follow-up of patients showed 100% pain and fissure improvement in internal lateral sphincterotomy group as compared to 60% in glyceryl trinitrate ointment group respectively. Conclusion: Internal lateral sphincterotomy is most efficient and reliable procedure in relieving anal fissure pains. Keywords: Anal fissure, Internal lateral sphincterotomy, Glyceryl trinitrate

scholarly journals Comparative study of Glyceryl Trinitrate ointment versus lateral internal sphincterotomy in management of Chronic anal fissure.

2019 ◽  
Vol 26 (12) ◽  
pp. 2241-2245
Author(s):  
Waqas Hussain Qureshi ◽  
Zahid Sattar ◽  
Akhtar Mahboob ◽  
Aakif Yousaf ◽  
Sajid Mukhtar ◽  
...  
Keyword(s):  
Pain Relief ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Lateral Internal Sphincterotomy ◽  
P Value ◽  
Internal Sphincterotomy ◽  
Randomized Control ◽  
Glyceryl Trinitrate Ointment ◽  
Trial Setting

Objectives: To compare efficacy of topical 0.2% glyceryl trinitrate ointment with lateral internal sphincterotomy in treatment of patients with chronic anal fissure. Study Design: Randomized Control Trial. Setting: Department of General Surgery, DHQ Teaching Hospital, Sahiwal. Period: From 20 September 2016 to 31 December 2017. Material & Methods: A total number of 60 patients included in this study and divided into two groups GTN and LIS group through computer generated randomization method. Three main outcome variables were assessed in this study; pain relief, healing of fissure and recurrence. SPSS version was used to analyze data. P value ≤ 0.05 was considered as significant. Results: A total number of 60 patients included in this study. Relief of pain GTN and LIS was (95%) and (86.7%) respectively. Fissure healing GTN and LIS was noted as (88.3%) and (83.3%) respectively. Recurrence was not found in any patient of the present study. Relief of pain was statistically significant. Conclusion: Topical application of GTN ointment for relief of pain is safe and effective method for relief of chronic anal fissure but pain relief is slow. On other hand lateral internal sphincterotomy is first line treatment and treatment of choice for chronic anal fissure when performed by an experienced surgeon.

Glyceryl trinitrate ointment for chronic anal fissure

The Lancet ◽  
1997 ◽  
Vol 349 (9051) ◽  
pp. 573
Author(s):  
Jonathan N Lund ◽  
John H Scholefield
Keyword(s):  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Glyceryl Trinitrate Ointment

Effectiveness and Complications of 0.2% Glyceryl Trinitrate in the Treatment of Chronic Anal Fissure

1970 ◽  
Vol 25 (1) ◽  
pp. 14-17 ◽  
Author(s):  
KM Murshed ◽  
MI Siddique ◽  
MA Rahman
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Symptom Relief ◽  
Major Side Effect ◽  
Primary Focus ◽  
A Prospective Study

Background: The aim of this study was to analyze the effectiveness and morbidity of chemical sphincterotomy by 0.2% glyceryl trinitrate (GTN) in the treatment of chronic anal fissure. The main end points were symptom relief, fissure healing and side effects. Methods: A prospective study was conducted to see the effectiveness and side effects of 0.2% glyceryl trinitrate in the treatment of patients with chronic anal fissure attending the outpatient department of surgery from February 2004 to the end of February 2005. All the patients were followed up at 2 weeks interval for 8 weeks. The primary focus was fissure healing and the secondary focus were on improvement of symptoms, need for surgical sphincterotomy and side effects. Results: One hundred and twenty two adult patients, both male and female with chronic anal fissure were treated with local application of 0.2% glyceryl trinitrate. Pain relief occurred earlier than fissure healing. At the end of 8 weeks treatment about two third of the total patients got complete pain relief and fissure healing. Headache was the major side effect. Conclusion: Topical application of 0.2% glyceryl trinitrate (GTN) should be the initial treatment of choice for chronic anal fissure to avoid the long term complication of incontinence following surgical sphincterotomy. (J Bangladesh Coll Phys Surg 2007; 25 : 14-17)

Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure

2001 ◽  
Vol 44 (1) ◽  
pp. 93-97 ◽  
Author(s):  
Justin Evans ◽  
Andrew Luck ◽  
Peter Hewett
Keyword(s):  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Lateral Sphincterotomy

scholarly journals Comparative Study of Glyceryl Trinitrate Ointment Versus Surgical Management of Chronic Anal Fissure

2011 ◽  
Vol 73 (4) ◽  
pp. 268-277 ◽  
Author(s):  
Leo Francis Tauro ◽  
Vittal V. Shindhe ◽  
P. Sathyamoorthy Aithala ◽  
John J. S. Martis ◽  
H. Divakar Shenoy
Keyword(s):  
Comparative Study ◽  
Glyceryl Trinitrate ◽  
Anal Fissure ◽  
Surgical Management ◽  
Chronic Anal Fissure ◽  
Glyceryl Trinitrate Ointment
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