Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation

2019 ◽  
Vol 30 (4) ◽  
pp. 311-319 ◽  
Author(s):  
Man Li ◽  
Weiwen Wang ◽  
Lan Sun ◽  
Wei Du ◽  
Hao Zhou ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mrna Expression ◽  
Social Isolation ◽  
Prepulse Inhibition ◽  
Medial Prefrontal Cortex ◽  
Bdnf Mrna ◽  
Clozapine Treatment

scholarly journals BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shao-Han Chang ◽  
Ying Hao Yu ◽  
Alan He ◽  
Chen Yin Ou ◽  
Bai Chuang Shyu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mrna Expression ◽  
Medial Prefrontal Cortex ◽  
Mrna Levels ◽  
Traumatic Memory ◽  
Ptsd Symptoms ◽  
Infralimbic Cortex ◽  
Bdnf Expression ◽  
Bdnf Mrna ◽  
Cortex Area

Whether BDNF protein and BDNF mRNA expression of the medial prefrontal cortex (mPFC; cingulated cortex area 1 (Cg1), prelimbic cortex (PrL), and infralimbic cortex (IL)), amygdala, and hippocampus (CA1, CA2, CA3, and dentate gyrus (DG)) was involved in fear of posttraumatic stress disorder (PTSD) during the situational reminder of traumatic memory remains uncertain. Footshock rats experienced an inescapable footshock (3 mA, 10 s), and later we have measured fear behavior for 2 min in the footshock environment on the situational reminder phase. In the final retrieval of situational reminder, BDNF protein and mRNA levels were measured. The results showed that higher BDNF expression occurred in the Cg1, PrL, and amygdala. Lower BDNF expression occurred in the IL, CA1, CA2, CA3, and DG. BDNF mRNA levels were higher in the mPFC and amygdala but lower in the hippocampus. The neural connection analysis showed that BDNF protein and BDNF mRNA exhibited weak connections among the mPFC, amygdala, and hippocampus during situational reminders. The present data did not support the previous viewpoint in neuroimaging research that the mPFC and hippocampus revealed hypoactivity and the amygdala exhibited hyperactivity for PTSD symptoms. These findings should be discussed with the previous evidence and provide clinical implications for PTSD.

Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex.

2021 ◽  
Vol 135 (1) ◽  
pp. 32-38
Author(s):  
Auxiliadora Mena ◽  
Sandra López ◽  
Juan C. Ruiz-Salas ◽  
Aarón Fernández ◽  
Francisco J. Pérez-Díaz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Prepulse Inhibition ◽  
Medial Prefrontal Cortex ◽  
Inhibition Response

scholarly journals Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Manabu Makinodan ◽  
Daisuke Ikawa ◽  
Kazuhiko Yamamuro ◽  
Yasunori Yamashita ◽  
Michihiro Toritsuka ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Social Isolation ◽  
Medial Prefrontal Cortex ◽  
And Function
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