Azelnidipine Decreases Sympathetic Nerve Activity Via Antioxidant Effect in the Rostral Ventrolateral Medulla of Stroke-prone Spontaneously Hypertensive Rats

2008 ◽  
Vol 52 (6) ◽  
pp. 555-560 ◽  
Author(s):  
Satomi Konno ◽  
Yoshitaka Hirooka ◽  
Shuichiro Araki ◽  
Yasuaki Koga ◽  
Takuya Kishi ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerve Activity ◽  
Antioxidant Effect ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Hypertensive Rats ◽  
Nerve Activity ◽  
Spontaneously Hypertensive

scholarly journals Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats

2020 ◽  
Vol 318 (1) ◽  
pp. H124-H134 ◽  
Author(s):  
Zhi Geng ◽  
Chao Ye ◽  
Ying Tong ◽  
Feng Zhang ◽  
Ye-Bo Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerve Activity ◽  
Akt Pathway ◽  
Sympathetic Activation ◽  
Hypertensive Rats ◽  
Nerve Activity ◽  
Vasopressin Release ◽  
Spontaneously Hypertensive

Elabela (ELA) is a newly discovered peptide that acts as a novel endogenous ligand of angiotensin receptor-like 1 (APJ) receptor. This study was designed to evaluate the effects of ELA-21 in paraventricular nucleus (PVN) on blood pressure and sympathetic nerve activity in spontaneously hypertensive rats (SHR). Experiments were performed in male Wistar-Kyoto rats (WKY) and SHR. ELA expression was upregulated in PVN of SHR. PVN microinjection of ELA-21 increased renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), heart rate (HR), plasma norepinephrine, and arginine vasopressin (AVP) levels in SHR. Intravenous injection of ELA-21 significantly decreased MAP and HR in both WKY and SHR, but only induced a slight decrease in RSNA. APJ antagonist F13A in PVN abolished the effects of ELA-21 on RSNA, MAP and HR. Intravenous infusion of both ganglionic blocker hexamethonium and AVP V1a receptor antagonist SR49059 caused significant reduction in the effects of ELA-21 on RSNA, MAP and HR in SHR, while combined administration of hexamethonium and SR49059 abolished the effects of ELA-21. ELA-21 microinjection stimulated Akt and p85α subunit of phosphatidylinositol 3-kinase (PI3K) phosphorylation in PVN, whereas PI3K inhibitor LY294002 or Akt inhibitor MK-2206 almost abolished the effects of ELA-21 on RSNA, MAP, and HR. Chronic PVN infusion of ELA-21 induced sympathetic activation, hypertension, and AVP release accompanied with cardiovascular remodeling in normotensive WKY. In conclusion, ELA-21 in PVN induces exacerbated pressor and sympathoexcitatory effects in hypertensive rats via PI3K-Akt pathway. NEW & NOTEWORTHY We demonstrated that PVN microinjection of ELA-21 increases sympathetic nerve activity and blood pressure, which can be abolished by pretreatment of APJ antagonist. This is the first demonstration that central ELA can induce hypertension. The pressor effects in PVN are mediated by both sympathetic activation and vasopressin release via PI3K-Akt pathway. Our data confirm that ELA is upregulated in the PVN of SHR and so may be involved in the pressor and sympathoexcitatory effects in hypertension.

scholarly journals The Effect of Propranolol on Blood Pressure and Sympathetic Nerve Activity in the Spontaneously Hypertensive Rats

1980 ◽  
Vol 21 (4) ◽  
pp. 563-563 ◽  
Author(s):  
Kasuo Takeda ◽  
Susumu Sasaki ◽  
Isao Kaimasu ◽  
Manabu Yoshimura ◽  
Masao Nakagawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Spontaneously Hypertensive Rats ◽  
Sympathetic Nerve Activity ◽  
Hypertensive Rats ◽  
Nerve Activity ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document