Influence of Underlying Disease on Busulfan Disposition in Pediatric Bone Marrow Transplant Recipients: A Nonparametric Population Pharmacokinetic Study

2007 ◽  
Vol 29 (2) ◽  
pp. 177-184 ◽  
Author(s):  
V Bertholle-Bonnet ◽  
N Bleyzac ◽  
C Galambrun ◽  
V Mialou ◽  
Y Bertrand ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Pharmacokinetic Study ◽  
Underlying Disease ◽  
Marrow Transplant ◽  
Population Pharmacokinetic ◽  
Transplant Recipients ◽  
Population Pharmacokinetic Study

An Outbreak of Invasive Aspergillosis Among Allogeneic Bone Marrow Transplants: A Case-Control Study

1985 ◽  
Vol 6 (9) ◽  
pp. 347-355 ◽  
Author(s):  
Coleman Rotstein ◽  
K. Michael Cummings ◽  
John Tidings ◽  
Kathleen Killion ◽  
Eileen Powell ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Invasive Aspergillosis ◽  
Bone Marrow Transplant ◽  
Case Control Study ◽  
Underlying Disease ◽  
Marrow Transplant ◽  
Case Control ◽  
Allogeneic Bone ◽  
Transplant Recipients ◽  
Control Study

AbstractBetween April 1982 and March 1983,10 of 26 (38.4%) allogeneic bone marrow transplant recipients housed on a newly opened bone marrow transplant unit developed invasive aspergillosis. By contrast, between September 1977 and March 1982, only 3 of 46 (6%) transplant recipients developed invasive aspergillosis. A case-control study to identify host factors related toAspergillusinfection found that aspergillosis was more common in patients with chronic myelogenous leukemia and aplastic anemia, older patients, patients having cytomegalovirus disease, patients who experienced prolonged granulocytopenia, patients conditioned with ara-C (100-200 mg/day), and patients who received longer duration of antimicrobial therapy. A series of logistic regression analyses revealed that underlying disease was the single best predictor ofAspergillusinfection. This study demonstrates that underlying disease is an important risk factor for aspergillosis and that special measures may be warranted when transplanting certain patients.

Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients

1994 ◽  
Vol 169 (4) ◽  
pp. 775-781 ◽  
Author(s):  
P. Flomenberg ◽  
J. Babbitt ◽  
W. R. Drobyski ◽  
R. C. Ash ◽  
D. R. Carrigan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Transplant Recipients
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