Case Control Study
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The Knee ◽  
2021 ◽  
Vol 33 ◽  
pp. 49-57
Vanessa Knust Coelho ◽  
Bruno Senos Queiroz Gomes ◽  
Thiago Jambo Alves Lopes ◽  
Leticia Amaral Corrêa ◽  
Gustavo Felicio Telles ◽  

2021 ◽  
Vol 9 (27) ◽  
pp. 8008-8019
Yin Sun ◽  
Zhong-Zhou Shen ◽  
Fei-Ling Huang ◽  
Yu Jiang ◽  
Ya-Wen Wang ◽  

2021 ◽  
Ying Zhao ◽  
Dong'e Liu ◽  
Nenghui Liu ◽  
Yumei Li ◽  
Zhongyuan Yao ◽  

Abstract Objective: To evaluate the relationship between the endometrial features (endometrial thickness(EMT), pattern and endometrium growth amplitude and rate) and the embryo stage transferred and ectopic pregnancy after IVF-ET based on the data of 628 matched cases. Methods: This was a 1:1 matched case-control study that enrolled 314 EP patients and 314 matched IUP patients from the ART center of Xiangya Hospital of Central South University from January 2014 to April 2020. Univariate analysis and multiple-stepwise logistic regression analysis was used to analyze the risk factors of EP, and a receiver-operating characteristic (ROC) curve was generated to predict EP. Results: 1. The EP group had a higher cleavage stage embryo transfer rate(94.57% vs 86.22%), a thinner endometrium on transformation day (the day when progesterone was added in the frozen embryo cycle or the trigger day in the fresh embryo cycle) (9.40(2.60) mm vs 9.80(2.60)mm) compared with IUP group. In fresh embryo cycles, the EP group had a higher endometrium pattern C proportion on transformation day, a smaller endometrium increment, and a slower endometrial growth rate compared with the IUP group. 2.The ROC curves were used to analyze the cut-off values of the EMT on transformation day, the endometrial growth amplitude and rate in fresh cycles, the results were 9.35mm, 4.90mm and 0.491 mm/d, respectively. The incidence of EP was significantly different between groups according to cut-off values. 3. The transferred embryo stage and EMT on transformation day were independent factors affecting outcome in the general population. The area under the curve(AUC) of the EMT and the stage of embryos transferred for EP prediction was 0.604, sensitivity was 0.702, and specificity was 0.465. The EMT on trigger day was an independent factor affecting outcome in the fresh cycles. The AUC of the EMT for EP prediction in fresh cycles was 0.605, sensitivity was 0.805, and specificity was 0.420. Conclusions: 1. Transferring cleavage stage embryo , and thin EMT on the transformation day were risk factors for EP. 2. Thin EMT and pattern C on transformation day may be related to abnormal endometrial receptivity and endometrial peristaltic waves. 3.The combined indicator of EMT and embryonic development stage could not well predict the occurrence of EP after ET.

Atieh Akbari ◽  
Mohammad Hassan Sohouli ◽  
Oana Deliu Ozovanu ◽  
Mojtaba Lotfi ◽  
Raheleh Nabavizadeh ◽  

Naiara Fernandez-Arroyabe ◽  
Gaspar García-Meléndez ◽  
Ana Raquel De Castro-Almeida ◽  
Francisca Escalona-Perez ◽  
Almudena Pérez-Lara ◽  

2021 ◽  
Qianli Liu ◽  
Xiaohui Li ◽  
Zhengzheng Han ◽  
Chun Hong

Abstract Background: Pneumomediastinum is an emergency pediatric disease. A severe tension pneumomediastinum can result in respiratory and circulatory dysfunction. However, few papers describe surgical methods to treat tension pneumomediastinum in a normative manner.Methods: We did a case-control study of 104 pediatric patients with tension pneumomediastinum and comorbid type II respiratory failure. Fifty-two patients were treated with a drainage strip being inserted into the pre-tracheal space while other 52 patients were treated without drainage. Arterial blood pO2 and pCO2 after 30 minutes and 12 hours of mechanical ventilation, chest radiography results after 12 hours of mechanical ventilation, and the length of stay in PICU of the two groups were analyzed by paired t-tests and Chi-square.Results: Chest radiography after 12 hours of mechanical ventilation showed that the pneumomediastinum basically disappeared in the surgery group but did not decrease significantly in the control group. The arterial blood pCO2 after 12 hours of mechanical ventilation and the length of stay in PICU were significantly lower in the surgery group than in the control group (p<0.001, p<0.001), while the arterial blood pO2 after 12 hours of mechanical ventilation was significantly higher in the surgery group than in the control group (p<0.001). There were no significant intergroup differences in other variables. No recurrence occurred in either group during 7–14 days after discharge, and all patients recovered.Conclusions: Our method for draining tension pneumomediastinum improved respiratory function and shortened the length of stay in PICU.Trial registration: ChiCTR2000039496. Date of registration: 2021/2/25 (retrospectively registered).

2021 ◽  
Paul M McKeigue ◽  
David McAllister ◽  
Chris Robertson ◽  
Sharon J Hutchinson ◽  
Stuart McGurnaghan ◽  

Objectives - To determine whether COVID-19 efficacy varies with clinical risk category and to investigate risk factors for severe COVID-19 in those who have received two doses of vaccine. Design - Matched case-control study (REACT-SCOT). Setting - Population of Scotland from 1 December 2020 to 19 August 2021. Main outcome measure - Severe COVID-19, defined as cases with entry to critical care or fatal outcome. Results - Efficacy against severe COVID-19 of two doses of vaccine was 93% (95 percent CI 90% to 95%) in those without designated risk conditions, 89% (95 percent CI 85% to 92%) in those with moderate risk conditions, but only 66% (95 percent CI 52% to 76%) in those designated as clinically extremely vulnerable (CEV) and eligible for shielding. Of the 330 cases of severe COVID-19 in double-vaccinated individuals, 47% had moderate risk conditions and 41% were CEV. In the double-vaccinated CEV group, the rate ratio for severe disease (with no risk condition as reference category) was highest in solid organ transplants at 98 (95% CI 29 to 332) but even in this subgroup the absolute risk of severe COVID-19 was low (14 cases in 16079 person-months of follow-up). Conclusions - Two doses of vaccine protect against severe COVID-19 in CEV individuals but the residual risk in double-vaccinated individuals remains far higher in those who are CEV than in those who are not. These results suggest that any policy of offering booster doses to doubly-vaccinated individuals should focus initially on the clinically vulnerable, and lay a basis for determining eligibility for passive immunization to protect those at highest risk.

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