Trends in Early Graft Failure Leading to Regrafting After Endothelial Keratoplasty in the United States

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michael J. Fliotsos ◽  
Jack A. Campbell ◽  
Ximin Li ◽  
Marie B. Engstrom ◽  
Christopher G. Stoeger ◽  
...  
Keyword(s):  
United States ◽  
Graft Failure ◽  
The United States ◽  
Endothelial Keratoplasty ◽  
Early Graft ◽  
Early Graft Failure

Outcomes of Repair of Total Graft Detachment following Descemetʼs Membrane Endothelial Keratoplasty

2021 ◽  
Author(s):  
Avital Adler ◽  
Eliane Rozanes ◽  
Peter Ciechanowski ◽  
Yoav Nahum ◽  
Shmuel Graffi ◽  
...  
Keyword(s):  
Electronic Medical Records ◽  
Medical Records ◽  
Graft Failure ◽  
Salvage Surgery ◽  
Endothelial Keratoplasty ◽  
Medical Centers ◽  
Early Graft ◽  
Secondary Operations ◽  
Early Graft Failure

Abstract Objective To present the outcomes of attempts to salvage total graft detachment following Descemetʼs membrane endothelial keratoplasty (DMEK). Methods A search of the electronic medical records of two tertiary medical centers for all patients who underwent DMEK yielded six cases of postoperative total graft detachment (2.54%). Graft salvage was attempted in all cases using repeated intracameral graft staining, unfolding, and reattachment to the stroma under 20% hexafluoride gas. Results In all cases, a free-floating totally detached graft was identified in the anterior chamber shortly after surgery. Salvage surgery resulted in a central, well-oriented, and fully attached graft. In three cases, the primary graft failed, and in two, the corneas cleared at first but failed after 2 months and 1 year respectively. In one case, the cornea remained clear during 1 year of follow-up but had a very low endothelial cell density. Conclusion Reattachment of fully detached DMEK graft is technically possible, but graft manipulation during the primary and secondary operations is likely to damage the endothelial cells, resulting in primary or early graft failure. If graft salvage is attempted, the probability of primary or early graft failure should be discussed with the patient, and expectations should be tempered accordingly.

Platelet Adhesion in Polytetrafluoroethylene (PTFE) Vascular Grafts In Vivo and the Influence of Increased Intramuscular Pressure-An Experimental Model

1983 ◽  
Vol 50 (04) ◽  
pp. 881-884 ◽  
Author(s):  
J T Christenson ◽  
P Qvarfordt ◽  
S-E Strand ◽  
D Arvidsson ◽  
T Sjöberg ◽  
...  
Keyword(s):  
Blood Flow ◽  
Graft Failure ◽  
Small Diameter ◽  
Graft Material ◽  
Intramuscular Pressure ◽  
Initial Flow ◽  
Early Graft ◽  
Wick Technique ◽  
Early Graft Failure

SummaryThrombogenicity of graft material is involved in early graft failure in small diameter grafts. The frequently seen postoperative swelling of the leg after distal revascularization may cause an increased intramuscular pressure and early graft failure.Pairs of 4 mm polytetrafluoroethylene (PTFE) grafts were implanted. Autologous platelets were labeled with mIn-oxine. Platelet adhesiveness onto the grafts were analyzed from gamma camera images. Intramuscular pressures were measured with wick technique. Blood flow was measured. One graft served as control the other as test graft. Ninety minutes after declamping the i. m. pressure was increased in the test-leg to 30 mmHg, and later to 60 mmHg.In the control-graft platelet uptake increased to a maximum 60 min after declamping. Blood flow and i.m. pressure remained uneffected. The test-grafts were initially similar but when i.m. pressure was increased to 30 mmHg activity in the grafts increased significantly. Blood flow decreased with 12% of initial flow. When i. m. pressure was raised to 60 mmHg platelet uptake continued to increase.An increased intramuscular pressure of 30 mmHg or more significantly increase the amount of platelets adhering onto PTFE grafts, emphasizing the need for measuring intramuscular pressures after lower limb vascular revascularizations.

Correlation of laboratory and ECG changes with early graft failure after CABG

2005 ◽  
Vol 53 (S 01) ◽  
Author(s):  
A Schnell ◽  
A Künzli ◽  
B Seifert ◽  
O Reuthebuch ◽  
M Lachat ◽  
...  
Keyword(s):  
Graft Failure ◽  
Ecg Changes ◽  
Early Graft ◽  
Early Graft Failure

Virchow Triad, but Not Use of an Aortic Connector Device, Predicts Early Graft Failure after Off-Pump Coronary Bypass

2004 ◽  
Vol 7 (5) ◽  
pp. E428-E433 ◽  
Author(s):  
Robert Poston ◽  
Charles White ◽  
Katrina Read ◽  
Junyan Gu ◽  
Andrew Lee ◽  
...  
Keyword(s):  
Graft Failure ◽  
Coronary Bypass ◽  
Off Pump ◽  
Early Graft ◽  
Early Graft Failure ◽  
Aortic Connector

scholarly journals Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jinsoo Rhu ◽  
Jong Man Kim ◽  
Kyunga Kim ◽  
Heejin Yoo ◽  
Gyu-Seong Choi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Prediction Model ◽  
Aspartate Aminotransferase ◽  
Graft Failure ◽  
Living Donor ◽  
Total Bilirubin ◽  
Deceased Donor ◽  
Time Dependent ◽  
Early Graft ◽  
Early Graft Failure

AbstractThis study was designed to build models predicting early graft failure after liver transplantation. Cox regression model for predicting early graft failure after liver transplantation using post-transplantation aspartate aminotransferase, total bilirubin, and international normalized ratio of prothrombin time was constructed based on data from both living donor (n = 1153) and deceased donor (n = 359) liver transplantation performed during 2004 to 2018. The model was compared with Model for Early Allograft Function Scoring (MEAF) and early allograft dysfunction (EAD) with their C-index and time-dependent area-under-curve (AUC). The C-index of the model for living donor (0.73, CI = 0.67–0.79) was significantly higher compared to those of both MEAF (0.69, P = 0.03) and EAD (0.66, P = 0.001) while C-index for deceased donor (0.74, CI = 0.65–0.83) was only significantly higher compared to C-index of EAD. (0.66, P = 0.002) Time-dependent AUC at 2 weeks of living donor (0.96, CI = 0.91–1.00) and deceased donor (0.98, CI = 0.96–1.00) were significantly higher compared to those of EAD. (both 0.83, P < 0.001 for living donor and deceased donor) Time-dependent AUC at 4 weeks of living donor (0.93, CI = 0.86–0.99) was significantly higher compared to those of both MEAF (0.87, P = 0.02) and EAD. (0.84, P = 0.02) Time-dependent AUC at 4 weeks of deceased donor (0.94, CI = 0.89–1.00) was significantly higher compared to both MEAF (0.82, P = 0.02) and EAD. (0.81, P < 0.001). The prediction model for early graft failure after liver transplantation showed high predictability and validity with higher predictability compared to traditional models for both living donor and deceased donor liver transplantation.

scholarly journals Structural degeneration of pulmonary homografts used as aortic valve substitute underlines early graft failure

2002 ◽  
Vol 22 (5) ◽  
pp. 802-807 ◽  
Author(s):  
D KOOLBERGEN ◽  
M HAZEKAMP ◽  
E DEHEER ◽  
F VANHOORN ◽  
H HUYSMANS ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Graft Failure ◽  
Early Graft ◽  
Early Graft Failure

Graft for Immediate use as First Stage of a Native Fistula

2009 ◽  
Vol 10 (3) ◽  
pp. 203-206 ◽  
Author(s):  
Earl Schuman
Keyword(s):  
United States ◽  
Graft Failure ◽  
The United States ◽  
Morbidity And Mortality ◽  
Dialysis Access ◽  
New Paradigm ◽  
Novel Approach ◽  
Native Fistula ◽  
Fistula Maturation

The majority of patients in the United States begin hemodialysis with a catheter. Many have immature or inadequate fistulae. At 90 days 77% of these patients are still using a catheter or a graft. The morbidity and mortality from prolonged catheter use have been well delineated. Although most of us adhere to the DOQI and Fistula First tenets, a fistula at all costs can seem counterproductive. A new paradigm is needed. The techniques described in this paper offer a novel approach to circumvent the problems of increasing catheter use and long fistula maturation times. The graft for immediate use is placed in the forearm and allows the proximal vessels to mature while providing dialysis access without a catheter. When these vessels meet maturation guidelines, or when surveillance indicates impending graft failure, a native fistula can be constructed and used in a 2–3 week period. This approach minimizes or circumvents catheter use altogether.

scholarly journals OKT-3-based reconditioning regimen for early graft failure in HLA-non-identical stem cell transplants

2000 ◽  
Vol 111 (2) ◽  
pp. 668-673
Author(s):  
P. G. Schlegel ◽  
M. Eyrich ◽  
P. Bader ◽  
R. Handgretinger ◽  
P. Lang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Graft Failure ◽  
Cell Transplants ◽  
Early Graft ◽  
Stem Cell Transplants ◽  
Early Graft Failure
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